Management of Type IIb Dyslipidemia

Abstract

Although the Japan Atherosclerosis Society guideline for the diagnosis and prevention of atherosclerosis cardiovascular diseases for the Japanese population provides targets for low-density lipoprotein (LDL) cholesterol, triglycerides, and high-density lipoprotein (HDL) cholesterol to prevent cardiovascular disease in patients with dyslipidemia, there is no guideline specifically targeting the treatment of type b dyslipidemia, which is one of the most common types of dyslipidemia, along with type a and type dyslipidemia. Type b dyslipidemia is important because it sometimes accompanies atherogenic lipid profiles, such as small, dense LDL, remnants, low HDL cholesterolemia. It is also associated with type 2 diabetes mellitus, metabolic syndrome, and chronic kidney disease (CKD), and most patients with familial combined hyperlipidemia (FCHL) show this phenotype; therefore, it is assumed that patients with type b dyslipidemia have a high risk for cardiovascular disease. Thus, the management of type b dyslipidemia is very important for the prevention of cardiovascular disease, so we have attempted to provide a guideline for the management of type b dyslipidemia.

Evaluation of Hypertriglyceridemia using Non-fasting Health Checkup Data in a Japanese Population

“…The characteristics of the well recognized to be a cardiovascular risk factor [4][5][6][7] , and it is of health care importance to detect sustained hypertriglyceridemia as well as other metabolic abnormalities. Recently, the American Heart Association (AHA) scientific statement proposed 2.3 mmol/l (200 mg/dl) as a non-fasting cutoff point for screening 8) .…”

Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events

“…Type IIb dyslipidemia is important, because it sometimes accompanies atherogenic lipid profiles, such as small dense LDL, remnant lipoprotein and low HDL cholesterolemia. It is also associated with type 2 diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD), and most patients with familial combined hyperlipidemia (FCHL) show this phenotype . Therefore, it is necessary to understand that patients with type IIb dyslipidemia have a high risk for CVD.…”

“…Many lines of evidence show that low‐density lipoprotein cholesterol (LDL‐C) is an important risk factor for cardiovascular disease (CVD; CVD = IHD + CVA), but it is still debatable whether plasma triglyceride (TG) levels are associated with the occurrence of CVD. However, recent reports have shown that plasma TG levels are an independent risk factor for coronary artery disease (CAD) . In addition, non‐fasting TG levels have been shown to be associated with CAD and stroke .…”

The Condition of the Coronary Arteries in Patients With Coronary Heart Disease and Diabetes Mellitus Type 2 Depending on the Types of Dyslipidemias

“…визначено, що у хво-рих на ІХС та ЦД 2-го типу переважно спостері-гався IIb тип дисліпідемій, в осіб, які страждають на ІХС без ЦД, превалював IIа тип дисліпідемії [2]. Підтвердження переважання IIb типу дисліпі-демій у хворих на ІХС та ЦД 2-го типу знаходи-мо і в роботі японських учених на чолі з Arai H. та співавторів [8], де виявлено несприятливий вплив даного типу дисліпідемії на підвищення ризику розвитку серцево-судинних ускладнень у хворих на ЦД 2-го типу. Висновки 1.…”