Context: The present study used a strategic approach to develop a conceptual framework for evaluating the curriculum effectiveness, which appears not to be limited to the internal dimension as far as the strategic approach is concerned as a comprehensive, environment-based and future-oriented method including both external and institutional dimensions. Evidence Acquisition: Given that the available information about the effectiveness of medical education curriculum based on a strategic approach is institutionally qualitative, multidimensional and consequential, exploring, extracting and analyzing the related data requires using a qualitative model for dealing with the diversity of resources and information. A review of literature suggested that the cyclical process of analysis is a qualitative research method with the required characteristics consisting of the following phases: (1) Data collection process, (2) data reduction, (3) data organization and analysis, and (4) conclusion (interpretation and conclusion). Triangulation was used to validate the findings of the research method. Results: Certain components of the effectiveness evaluation of medical education curriculum based on a strategic approach include achieving the internal goals of curriculum, satisfying the requirements of the internal environment through curriculum implementation, developing students' knowledge, attitude and skills, the internal coherence and consistency of the curriculum and the internal quality of the curriculum. These components also include fulfilling the goals, social acceptance of the curriculum, significant roles in social development, national self-sufficiency, proper performance and the education system reforms, improving the external image, and the strategic success of medical education curriculum. Conclusions: The results of these comprehensive strategies include knowledge and skill adjustment, professional responsibility, spirit of accepting the change, flexibility, adaptability to the varying environment, optimal use of resources, and receiving feedbacks on the effectiveness of the implemented programs to modify or clarify the goals or strategic selections and decisions.