Managing Complications of Androgen Deprivation Therapy for Prostate Cancer

Holzbeierlein, Jeffrey M.

doi:10.1016/j.ucl.2005.12.008

Cited by 44 publications

(55 citation statements)

References 68 publications

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“…26,27 The potential consequences of ADT include osteoporosis, increased fat mass, anemia and perhaps cognitive decline, as well as hot flashes and sexual dysfunction. 28 Other studies on the effects of PC treatments noted that patients received secondary ADT, 3,29,30 but only one examined its effects on quality of life. 30 In that cross-sectional study, ADT decreased the role and sexual function among patients who received RT.…”

mentioning

confidence: 99%

Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

Krahn

Bremner

Tomlinson

et al. 2009

Prostate Cancer Prostatic Dis

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This study aims to examine and compare changes in quality of life after two common treatments for prostate cancer (PC), radical prostatectomy (RP) and radiation therapy (RT). Patients newly diagnosed with localized PC, scheduled to receive RP (n ¼ 68) or RT (n ¼ 66), completed three cancer/PC-specific psychometric instruments and three PC-specific utility instruments before treatment, and 2 and 12 months after treatment. We assessed the magnitude and time course of changes in psychometric and utility measures, and differences between treatments. The results showed that RP was associated with significant urinary and sexual dysfunction; RT caused bowel problems. Fatigue and pain were common to both. RP patients reported more problems with physical, role and social function. Utilities decreased significantly after both treatments. Effects were most severe 2 months post treatment, and then showed some recovery, but many endured for 1 year. After 1 year, 30-60% of patients had utility scores that were clinically significantly worse than at baseline. Secondary androgen deprivation therapy also significantly decreased psychometric and utility measures of quality of life. Many adverse symptoms reported 2 months after RP and RT endure for 1 year. Despite different symptom profiles, RP and RT result in similar utility decrements.

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mentioning

confidence: 99%

Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

Krahn

Bremner

Tomlinson

et al. 2009

Prostate Cancer Prostatic Dis

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“…On the other hand, chills, weight gain, and carpal tunnel-like pain are the reported side effects of megestrol acetate. 53 …”

Section: Vasomotor Symptoms "Hot Flashes"mentioning

confidence: 99%

Radiotherapy combined with hormonal therapy in prostate cancer: the state of the art

Milecki¹

2010

CMAR

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Androgen-deprivation therapy (ADT) is used routinely in combination with definitive external beam radiation therapy (EBRT) in patients with high-risk clinically localized or locally advanced disease. The combined treatment (ADT-EBRT) also seems to play a significant role in improving treatment results in the intermediate-risk group of prostate cancer patients. On the other hand, there is a growing body of evidence that treatment with ADT can be associated with serious and lifelong adverse events including osteoporosis, cardiovascular disease, diabetes, and many others. Almost all ADT adverse events are time dependant and tend to increase in severity with prolongation of hormonal manipulation. Therefore, it is crucial to clearly state the optimal schedule for ADT in combination with EBRT, that maintaining the positive effect on treatment efficacy would keep the adverse events risk at reasonable level. To achieve this goal, treatment schedule may have to be highly individualized on the basis of the patient-specific potential vulnerability to adverse events. In this study, the concise and evidence-based review of current literature concerning the general rationales for combining radiotherapy and hormonal therapy, its mechanism, treatment results, and toxicity profile is presented.

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“…This side effect is one of the most common side effects of ADT, with up to 80% of patients describing it [5,6] . Hot flushes are considered by patients as one of the most bothersome side effects of ADT that may largely disrupt everyday life.…”

Section: Hot Flushesmentioning

confidence: 99%

“…Considering this, many men with PCa will still receive ADT for a prolonged time, and although these men may benefit from ADT, they will also suffer from the side effects of this therapy. Traditionally, ADT is recognized through its acute obnoxious side effects such as loss of libido and erectile dysfunction, hot flushes, fatigue and psychological effects such as emotional instability, depression or cognitive dysfunction [3][4][5] . Recently, however, it has become clear that ADT-related morbidity comes mostly from long-term side effects that are mostly invisible to the patient [3] .…”

Section: Introductionmentioning

confidence: 99%

A Holistic Approach to Androgen Deprivation Therapy: Treating the Cancer without Hurting the Patient

Tombal¹

2009

Urol Int

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Introduction: Androgen deprivation therapy (ADT) for advanced prostate cancer can be associated with side effects which may negatively impact quality of life (QoL) and induce serious medical problems. Aim: The aim is to give practical recommendations on how to monitor and counsel patients and effectively manage side effects based on relevant original articles, review articles and abstracts. Results: Urologists should be aware of side effects and adapt their practice patterns to rapidly recognize these and administer appropriate treatment. Proper counseling of ADT-treated patients is needed to help them recognize and prevent and/or manage side effects. Patients should be encouraged to adopt a healthy lifestyle such as a healthy diet and physical exercise. In addition, bone mineral density and metabolic and cardiovascular parameters need to be carefully monitored. Conclusions: Urologists should take appropriate measures to prevent and manage ADT-related side effects to promote the general health and overall QoL of patients.

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Managing Complications of Androgen Deprivation Therapy for Prostate Cancer

Cited by 44 publications

References 68 publications

Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

Radiotherapy combined with hormonal therapy in prostate cancer: the state of the art

A Holistic Approach to Androgen Deprivation Therapy: Treating the Cancer without Hurting the Patient

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