“…6 For example, in 2022, Walter et al carried out a qualitative analysis of nursing staff's experiences in PJI management, highlighting that PJI has a high emotional burden for the patients, owing to the lack of social interaction contributing to it. 7 The difficulty of HI and PJI is mainly ascribed to difficulty in the timely correct diagnosis. The unmet medical and societal need is very well addressed in a review 8 written by several scientists belonging to AO Research Institute Davos, Switzerland, University Hospital of Basel, Switzerland, Ghent University, Belgium, University Hospitals Leuven, Belgium, Trauma Centre, Murnau, Germany, University of Rochester Medical Center, New York, USA, MC, University of Amsterdam, The Netherlands, Virginia Commonwealth University, Virginia, USA that reported, “ A considerable number of infections are ‘culture-negative’ despite being clinically apparent.…”