Managing recurrent bacterial vaginosis

Wilson, Janet

doi:10.1136/sti.2002.002733

Cited by 132 publications

(94 citation statements)

References 34 publications

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“…Furthermore, treatment alternatives are being sought, given that the conventional drugs (metronidazole and clindamycin) involve high relapse rates (18,19). Finally, it was reported in a previous study that the pepper tree extract was effective for curing bacterial vaginosis, since it seemed to preserve the vaginal environment through greater conservation of Lactobacillus (7).…”

Section: Discussionmentioning

confidence: 99%

Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Leite

Amorim

Sereno

et al. 2011

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Leite

Amorim

Sereno

et al. 2011

Braz J Med Biol Res

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“…The use of probiotics to replace lactobacilli (vaginal or oral), the use of acidifying gels to maintain vaginal pH ≤ 4.5, boric acid and tinidazole treatment, and preventing overgrowth of BVassociated bacteria with suppressive doses of antibiotics are methods still in need of development. [53][54][55][56][57] In summary, BV and its recurrence are common in adolescents attending STD clinics. This susceptible population should be screened for BV and those with disrupted vaginal ecology may benefit from intervention strategies aimed at preventing both BV and PID.…”

Section: Discussionmentioning

confidence: 99%

Findings Associated with Recurrence of Bacterial Vaginosis among Adolescents Attending Sexually Transmitted Diseases Clinics

Brotman

Erbelding

Jamshidi

et al. 2007

Journal of Pediatric and Adolescent Gynecology

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Study Objective-Bacterial vaginosis (BV) is a common infection and has been associated with adverse health outcomes, including preterm birth, pelvic inflammatory disease (PID) and acquisition and transmission of HIV. There are limited data on recurrent BV in adolescents. A relationship between the frequency of BV recurrence and specific risk factors might shed light on the pathophysiology of BV and lead to targeted interventions. Methods-Design:Record-based historical clinic study. Setting: Adolescent visits to two sexually transmitted disease (STD) clinics between 1990-2002. Participants: 254 girls who had ≥ 2 episodes of BV and at least 3 clinical visits, matched on clinic attendance frequency to 254 girls with only 1 documented BV episode and 254 girls with no history of BV. Main outcome measure: Risk factor differences between groups. Analysis: Multinomial logistic regression with robust estimator of the standard errors, accounting for repeated measures.Results-5,977 adolescent girls visited the clinics. 1509 (25%) had at least one episode of BV; of those, 303 (19.9%) had 2 or more BV episodes. Girls with a history of 1 BV episode and girls with a history of 2 or more BV episodes were more likely to be infected with Trichomonas vaginalis [OR 1.77, 95% CI: 1.17-2.67, OR 1.56, 95% CI: 1.05-2.34] and be diagnosed with PID [OR 1.50, 95% CI: 1.02-2.22, OR 2.05, 95% CI: 1.41-2.98] compared to girls with no BV history, respectively. Girls with a history of BV were also more likely to report active oral sex and lack of contraceptive use.

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“…In particular, microbial species inhabiting the human vagina are thought to play an important role in host health (10). A shift in the composition of the vaginal microbiota from "normal" (Lactobacillus dominated) to a state defined as bacterial vaginosis (BV; increased abundance of gram-negative organisms) is associated with a range of negative outcomes, including pelvic inflammatory disease, preterm births, and the acquisition of sexually transmitted diseases (21,22,37). This observation has led to an increased interest in determining the composition of the vaginal microbiota by culture-independent methods (8,11,17,25,30,35,36).…”

mentioning

confidence: 99%

Pyrosequencing of the Chaperonin-60 Universal Target as a Tool for Determining Microbial Community Composition

Schellenberg

Links

Hill

et al. 2009

Appl Environ Microbiol

100

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We compared dideoxy sequencing of cloned chaperonin-60 universal target (cpn60 UT) amplicons to pyrosequencing of amplicons derived from vaginal microbial communities. In samples pooled from a number of individuals, the pyrosequencing method produced a data set that included virtually all of the sequences that were found within the clone library and revealed an additional level of taxonomic richness. However, the relative abundances of the sequences were different in the two datasets. These observations were expanded and confirmed by the analysis of paired clone library and pyrosequencing datasets from vaginal swabs taken from four individuals. Both for individuals with a normal vaginal microbiota and for those with bacterial vaginosis, the pyrosequencing method revealed a large number of low-abundance taxa that were missed by the clone library approach. In addition, we showed that the pyrosequencing method generates a reproducible profile of microbial community structure in replicate amplifications from the same community. We also compared the taxonomic composition of a vaginal microbial community determined by pyrosequencing of 16S rRNA amplicons to that obtained using cpn60 universal primers. We found that the profiles generated by the two molecular targets were highly similar, with slight differences in the proportional representation of the taxa detected. However, the number of operational taxonomic units was significantly higher in the cpn60 data set, suggesting that the protein-encoding gene provides improved species resolution over the 16S rRNA target. These observations demonstrate that pyrosequencing of cpn60 UT amplicons provides a robust, reliable method for deep sequencing of microbial communities.

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Managing recurrent bacterial vaginosis

Cited by 132 publications

References 34 publications

Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis

Findings Associated with Recurrence of Bacterial Vaginosis among Adolescents Attending Sexually Transmitted Diseases Clinics

Pyrosequencing of the Chaperonin-60 Universal Target as a Tool for Determining Microbial Community Composition

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