Background: India is facing burden of non-communicable diseases and oral cancer is one of the leading public health issue. This is a descriptive study from Aurangabad district, Maharashtra, India to evaluate epidemiologic profile of oral cancer patients who underwent treatment during 2012 to 2016.Methods: Demographic and clinical profile of 500 patients was recorded with validated questionnaire.Results: With male: female ratio was 2.90:1; the mean age of the patients of oral cancer was 47.73 years. Tobacco consumption was the leading cause associated with statistically significant association (p value < 0.000) among the gender and tobacco use suggesting men are more prone to use tobacco than women. 74% patients received satisfactory treatment and all the patients strongly reported need of doctor’s advice, family support, discontinuation of substance abuse habits and financial help. Patients reported the need of acceptance by society and good diet and nutrition. However, many denied the need of psychological counseling and regular check-up. There was statistically significant association (p value < 0.001) found among the gender and needs for good diet and nutrition, psychological counseling, regular check-up, discontinuation of tobacco habits. Statistically significant association (p value < 0.001) found among the occupation and needs for good diet and nutrition, psychological counseling and acceptance by society.Conclusions: The study projects the epidemiology and focuses on the needs of the patients which require the specific attention and efforts through patient’s education and awareness.