Mandibular metastases from an ileum stromal tumor

Lutz, Jon; El-Bouihi, M.; Vidal, Nascimento; Fricain, Jean-Christophe; Robert, M.; Déminière, C.; Zwetyenga, N.

doi:10.1016/j.stomax.2008.09.010

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…Another report indicated the mandibular metastasis of a GIST. [10] Our case clearly revealed mandibular metastasis. Reinhard E. Friedrich et al published recent data on GIST showing metastasis to oral cavity.…”

Section: Discussionmentioning

confidence: 51%

Diagnosis of gastrointestinal stromal tumor in a 25-year-old female presenting as huge abdominal mass and mandibular metastasis on fine needle aspiration cytology

Brar

Sehgal

2016

CRCP

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Gastrointestinal stromal tumors (GISTs) are rare forms of mesenchymal tumors of the digestive tract. We present a case of 25-year-old female who presented with abdominal pain, vomiting and mandibular swelling. Buccal mucosa at the site of mandibular swelling was normal on histopathological examination. CT scan revealed a huge intra abdominal mass. Fine needle aspiration cytology (FNAC) was performed from the abdominal mass and mandibular swelling. It revealed similar morphology from both the sites, confirming metastasis of GIST to mandible. The highlight of this case was presentation of malignant GIST in a young female along with rare mandibular metastasis. Diagnosis by FNAC is rarely reported.

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Section: Discussionmentioning

confidence: 51%

Diagnosis of gastrointestinal stromal tumor in a 25-year-old female presenting as huge abdominal mass and mandibular metastasis on fine needle aspiration cytology

Brar

Sehgal

2016

CRCP

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“…The patient had been treated only with imatinib for 22 months at doses of 400 mg/day for 3 months followed by 600 mg/day for 4 months and then 800 mg/day and never with bisphosphonates or radiotherapy. In line with indications in the literature34, the oncologist did not suspend imatinib therapy because the GISTs were metastases. Clinical course after the tooth extraction included apparent healing in the first weeks followed by rapid local worsening leading to bone sequestration with pain, swelling, halitosis and partial hypoesthesia of the lower lip.…”

Section: Discussionmentioning

confidence: 88%

A rare case of osteonecrosis of the jaw related to imatinib

Viviano

Rossi

Cocca

2017

J Korean Assoc Oral Maxillofac Surg

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Osteonecrosis of the jaw (ONJ) is commonly described as an adverse effect of the use of bisphosphonates. A few cases of ONJ associated with tyrosine kinase inhibitors (sunitinib, imatinib) have been reported in the literature and usually they occurred in patients simultaneously treated with bisphosphonates. We report an atypical case of ONJ related only to imatinib. A 72-year-old male patient was treated with imatinib for metastases from gastrointestinal stromal tumors (GISTs). The patient developed ONJ after 22 months of imatinib only therapy. During his whole life, the patient had never been treated with bisphosphonates or radiotherapy. Microscope examination of the tissues confirmed the clinical diagnosis of diffuse osteonecrosis and showed absence of neoplastic cells. Thus, secondary localisations from GISTs were ruled out. Osteonecrosis of the lower jaw appeared 22 months after initial and exclusive therapy with imatinib. Therefore, imatinib monotherapy can induce ONJ in patients that have never been treated with bisphosphonates or radiotherapy.

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“…For example, when intracranial GIST metastasis occurs, it usually affects the nervous system, resulting in dizziness, headache, memory impairment, loss of sensation and inability to move a single limb, the inability to maintain body balance and abnormal gait and posture, along with a series of neurological crements (27,32,35,40,51,61,70,87,87,92,93). In cases of bone metastasis, pain manifests in the affected bone area (29,37,48,52,53,63,69,75,80,94,95), in cases of skeletal muscle involvement, a mass can be palpated in the affected area (34,49,71,72,79), and when metastasis occurs deep in the bone marrow, anemia may be present (96). Furthermore, when GIST metastasizes to the lungs, signs and symptoms that may be observed include dyspnea, blood in the sputum, coughing and shortness of breath (18,85,88,97).…”

Section: Diagnosis Of Rare Site Metastasis Of Gistmentioning

confidence: 99%

“…The magnetic resonance imaging (MRI) of cranial GIST metastasis shows equivocal masses in T1-and T2-weighted terms, with circumferential enhancement in T1-weighted sequences and inhomogeneous enhancement in T2-weighted sequences (40,61,70,104), while the intracranial aggregation of 18 F-fluorodeoxyglucose is not reported as being visible when examined using positron emission tomography (PET) (27,86,87,92). When GIST metastasizes to bone, it is primarily present in the spine (17), with CT plain scanning showing osteolytic bone destruction of the vertebral ody (29,31,37,47,52,53,69,76,78,81,84,94,95). Additionally, MRI reveals dural protrusion and compression of the spinal cord, usually with spinal stenosis, T1 and T2 high signals on enhancement scans and partial necrosis and non-uniform enhancement of the lesion (29,31,48,63,76,78,81,95).…”

Section: Diagnosis Of Rare Site Metastasis Of Gistmentioning

confidence: 99%

“…Treatment and prognosis details described in the literature for rare metastatic sites of GIST are shown in Table II (18,(20)(21)(22)(23)(24)(25)(26)(27)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)43,44,46,47,(50)(51)(52)(53)(54)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(69)(70)(71)(72)74,75,(77)…”

Section: Therapy and Prognosis For Rare Site Gist Metastasesmentioning

confidence: 99%

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Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

Liang

Kong

2022

Oncol Lett

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Gastrointestinal stromal tumors (GIST) are the most common stromal-derived tumors of the gastrointestinal tract and have a potential metastatic capacity in almost half of all cases, with the most common sites of metastasis being the liver and peritoneum. However, there is evidence that GIST metastasizes to sites other than the liver and peritoneum, which poses challenges for clinical diagnosis and treatment. Therefore, the Cochrane and Medline databases were searched via PubMed in July 2022 using relevant keywords to acquire the literature associated with the metastasis of GIST to rare sites published since from 2000 onwards. Study data comprising age, sex, primary location, metastatic site, mean survival time, clinical signs and symptoms, imaging, pathological features immunohistochemical indices, treatment and prognosis were recorded and analyzed. The 118 metastases at rare sites reported in the literature included bone (n=31), lung (n=10), lymph nodes (n=13), intracranial sites (n=13), skin and subcutaneous tissue (n=10), heart (n=7), skeletal muscle (n=7), orbit and choroid (n=6), pancreas (n=3), spleen (n=2), bone marrow (n=1), testis (n=3), scrotum (n=1), epididymis (n=1), penis (n=1), ovary (n=2), cervix (n=1), kidney (n=1), bladder (n=1), adrenal gland (n=2) and thyroid gland (n=2). From the reviewed studies, it may be concluded that when metastases from gastrointestinal stromal tumors occur at rare sites, the initial symptoms may help in the identification of these sites. In addition, the site-dependent imaging of different metastatic locations may further define the metastases, and the findings of pathological or immunohistochemical analyses may be used to confirm the diagnosis. Contents Introduction 2. Materials and methods3. Rare metastatic sites and basic characteristics of patients 4. Diagnosis of rare site metastasis of GIST 5. Therapy and prognosis for rare site GIST metastases 6.

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Mandibular metastases from an ileum stromal tumor

Cited by 11 publications

References 9 publications

Diagnosis of gastrointestinal stromal tumor in a 25-year-old female presenting as huge abdominal mass and mandibular metastasis on fine needle aspiration cytology

Diagnosis of gastrointestinal stromal tumor in a 25-year-old female presenting as huge abdominal mass and mandibular metastasis on fine needle aspiration cytology

A rare case of osteonecrosis of the jaw related to imatinib

Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

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