Odontogenic myxoma is a rare benign neoplasm with locally aggressive behaviour and a high risk of recurrence. It has a predilection for the mandible and occurs in the 2nd–3rd decade. The authors report a case of an odontogenic myxoma presenting with a spontaneous oro‐nasal fistula in a 29‐year‐old male. Histo‐pathological analysis of the incisional biopsy specimen initially suggested a diagnosis of calcifying epithelial odontogenic tumour. A partial maxillectomy was performed, and following assessment of the resection specimen, a diagnosis of odontogenic myxoma was rendered. A 3 cm bicortical iliac crest bone graft was harvested and inset to the right maxillary defect under general anaesthesia. Rehabilitation will be completed with the placement of implants.