Manejo obstétrico de la deficiencia hereditaria de antitrombina durante el embarazo y puerperio. Dos casos clínicos

Martínez, Milagros Cruz; Martínez, Amelia Vizcaíno; Reyes, Encarnación Arévalo; Hernández, Azahara Sarrión; Jaimez, Maria Dolores Fresneda

doi:10.1590/s1519-38292015000400008

Cited by 1 publication

(1 citation statement)

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“…Thrombosis is considered a multicausal pathology, and in recent years, more profound knowledge about its etiology has been obtained, as well as several factors that contribute to its incidence. Moreover, inheritance combined with genetic factors related to thrombophilia increases the risk of thrombotic episode occurrence [15] . In the early 19th century, Virchow described the mechanisms of thrombosis and reported a state of "altered blood composition", now called the hypercoagulable state.…”

Section: Pathology Mechanism and Complicationsmentioning

confidence: 99%

Gestational Thrombophilia

Casseb¹,

Casseb²,

Souza³

et al. 2022

Int J Innov Educ Res

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The woman's body undergoes several physiological changes during the gestational period. Risk factors and comorbidities can cause pathophysiological changes in this period, especially in the maternal vascular system, triggering thrombophilia. This clotting disorder increases the thrombus formation risk, especially in the uteroplacental circulation. The study aimed to conduct a thorough review of the main approaches to diagnosis and treatment in reducing patient morbidity and mortality. This is an integrative review with qualitative data searched in Pubmed, BVS and Cochrane Library. A total of 624 studies were found, 591 were excluded outside the inclusion criteria, and 33 were selected. According to the careful search, thrombophilias can be hereditary or acquired, the former when there is a predisposition to venous occlusion and the latter from other clinical conditions. Pregnancy is a pro-thrombotic event and increases the chances of thrombus occurrence, triggering a series of pregnancy complications, such as intrauterine death, early or late miscarriage, and premature birth. However, if diagnosed early, there is a favorable prognosis for the woman and the fetus. To reduce these impacts of gestational thrombophilia, it is imperative to train primary health care and private clinics professionals to promote and treat health and basic diagnostic tests on pregnant women. Thus, performing early intervention avoiding the development of maternal-fetal complications.

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Section: Pathology Mechanism and Complicationsmentioning

confidence: 99%