Manganese Balance and Clinical Observations in Young Men Fed a Manganese-Deficient Diet

Friedman, Bruce J.; Freeland‐Graves, Jeanne H.; Bales, Connie W.; Behmardi, Fares; Shorey-Kutschke, Roseann L.; Willis, Richard A.; Crosby, Jack B.; Trickett, Paul C.; Houston, Stephen D.

doi:10.1093/jn/117.1.133

Cited by 147 publications

(78 citation statements)

References 43 publications

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“…The SCF (1993) set an Acceptable Range of Intakes for adults at 1-10 mg/day, considering that most intakes were around 2-3 mg/day, that some reached 8.3 mg/day (Friedman et al, 1987;Hurley and Keen, 1987), that a basal average requirement of 0.74 mg/day had been derived from balance studies (Freeland-Graves et al, 1988) and that negative balances observed on dietary intakes between 1.21 and 2.89 mg/day could represent homeostasis (Freeland-Graves et al, 1988).…”

Section: Adultsmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for manganese

Products¹

2013

EFS2

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for manganese. Manganese is an essential dietary mineral which is a component of a number of metalloenzymes involved in amino acid, lipid and carbohydrate metabolism. A specific manganese deficiency syndrome has not been described in humans. The body is able to adapt to a wide range of manganese intakes by regulating both efficiency of absorption in the intestine and the quantity excreted via bile. There are no reliable and validated biomarkers of manganese intake or status and data on manganese intakes versus health outcomes are not available for DRVs for manganese. As there is insufficient evidence available to derive an average requirement or a population reference intake, an Adequate Intake (AI) is proposed. Mean intakes of manganese in adults in the EU are around 3 mg/day. In addition, null or positive balances have consistently been observed with intakes of manganese above 2.5 mg/day. An AI of 3 mg/day is proposed for adults, including pregnant and lactating women. For infants aged from 7 to 11 months, an AI of 0.02-0.5 mg/day is proposed, which reflects the wide range of manganese intakes that appear to be adequate for this age group. The AI for children and adolescents is based on extrapolation from the adult AI using isometric scaling and reference body weights of the respective age groups. Manganese is an essential dietary element for mammals. It is a component of metalloenzymes such as superoxide dismutase, arginase and pyruvate carboxylase, and is involved in amino acid, lipid and carbohydrate metabolism. A specific manganese deficiency syndrome has not been described in humans.Absorption of manganese in the intestine is low (< 10 %). Regulation at the level of absorption appears to be one of the adaptive responses to dietary manganese intake and such regulation allows manganese homeostasis to be maintained over a wide range of intakes. A reduction in the biological half-life of manganese has been observed with increased dietary manganese intakes indicating the role of whole-body turnover rate in manganese homeostasis. Elimination of manganese is primarily via the faeces.The assessment of manganese intake or status using biological markers is difficult owing to the rapid excretion of manganese into bile, to homeostatic mechanisms and to the lack of sensitivity of biomarkers over the normal range of intakes. Therefore, there are no reliable and validated biomarkers of manganese intake or status.Nuts, chocolate, cereal-based products, crustaceans and molluscs, pulses, and fruits and fruit products are rich sources of manganese. The main contributors to the manganese intake of adults are cerealbased products, vegetables, fruits and fruit products and beverages. In the EU, estimated mean manganese intakes of adults range from 2 to 6 mg/day, with a majority of values around 3 mg/day. Estimated mean manganese intakes range from 1.5 to 3.5 mg/day in ...

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Section: Adultsmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for manganese

Products¹

2013

EFS2

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“…Le Manganèse est un élément essentiel dans la nutrition humaine et contribue à la formation de tissu conjonctif et dans le métabolisme des lipides et des carbohydrates (Atsdr.2000, Beliles RP, 1994. Le manganèse joue un rôle dans la minéralisation des os, dans le métabolisme des protéines, dans la régulation métabolique, dans le fonctionnement du système nerveux (Freelandgraves JH et al 1987, Hurley LS et Keen CL, 1987, Wedler FC, 1994, dans la protection cellulaire contre les radicaux libres et dans la formation des glycosaminoglycans (Wedler FC, 1994) et la synthèse du cholestérol (Freedlandgraves JH et al, 1987, Friedman BJ et al, 1987. Il joue aussi un rôle enzymatique important (Keen CL et al, 1990, Nrc, 1989.…”

Section: Introductionunclassified

Détermination des teneurs en Magnésium, Potassium, Manganèse et Sodium de deux variétés de gombo.

Kouassi¹,

Massara²,

Sess³

et al. 2013

J. App. Bioscience.

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RESUME :Objectif : l'objectif de travail est de déterminer les teneurs en magnésium, potassium, manganèse et sodium de deux variétés de gombo ; Ensuite faire une étude comparative de ces teneurs par variété et par zone de culture. Méthodologie et résultats : En effet, deux variétés de gombo ont été cultivées ensemble sur 38 parcelles différentes dans la région de Yamoussoukro. Les fruits de chaque variété sont récoltés sur chaque parcelle de façon aléatoire en tenant compte de leur période de maturité. Les minéraux ont été déterminés par spectrophotométrie d'absorption atomique (SAA). Aucune différence significative (P>0.05) n'a été observée au niveau des teneurs en magnésium, potassium, manganèse et sodium par variété de gombo et par zone de culture au niveau de la variété Baoulé. Au niveau de la variété Dioula, une différence significative (P <0.05) a été seulement observée au niveau des teneurs en sodium. Conclusion et application : ces travaux indiquent que ces deux variétés sont très riches en magnésium, potassium, manganèse et sodium. Par ailleurs, cette étude constitue une première étape à l'élaboration d'une table de composition alimentaire, nécessaire pour évaluer la richesse du point de vue nutritionnelle des aliments ivoiriens afin d'encourager leur consommation. Mots clés : Teneurs, Potassium, Manganèse, Sodium, Magnésium, Gombo Determination of magnesium, potassium, manganese and sodium contents in two varieties of okra. Abstract Objective: the objective of this work is to determine the levels of magnesium, potassium, manganese and sodium of two varieties of okra and then to make a comparative study of these values by variety and growing area. Methodology and results: Two varieties of okra were grown together on 38 different plots in the Yamoussoukro region. The fruits of each variety are collected on each parcel in a random manner taking into account their maturity period. The minerals were determined by atomic absorption spectrophotometry (AAS). No significant difference (P> 0.05) was observed at the levels of magnesium, potassium, manganese and sodium by variety of okra and by the growing area of the Baoule variety. In the Dioula variety, a significant difference (P< 0.05) was observed only in the level of sodium content.

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“…Está diretamente envolvido com as enzimas fosfatase óssea, fosfatase alcalina e arginase, além de participar da síntese de proteínas que estimulam a ativação da DNA e da RNA polimerases (Wiberg e Neuman, 1957) e de colaborar com o metabolismo proteico e energético, e com síntese de colesterol e de mucopolissacarídeos (Friedman et al, 1987). Leach e Gross (1983) demonstraram que a deficiência de Mn na dieta de aves resultou em ovos com cascas mais finas, com alterações ultraestruturais na camada mamilar da casca e redução no teor de hexozamina e ácido hexurônico na matriz orgânica.…”

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