Manganese catalyzed asymmetric transfer hydrogenation of ketones

Novel Metallomacrocyclic Carboxamide Mn(II) Complexes as Efficient Catalysts for the Transfer Hydrogenation of Ketones

“…On the other hand, complexes Mn1-Mn4 demonstrated lower TOF than some highly active mononuclear Mn(I) catalysts previously reported. [47][48][49][50][51][52][53] For instance, while complex Mn1 gave a TOF up to 329 h À 1 per Mn(II) atom, the mononuclear Mn(I) tricarbonyl complexes reported by Wang et al [54] and Pidko et al [19] gave significantly higher TOFs of 2867 h À 1 and 4700 h À 1 , respectively (Table 3, entry 4, and 6).…”

Manganese-catalyzed hydrogenation, dehydrogenation, and hydroelementation reactions

“…Subsequently, Beller, 167 Sortais, 168 and Li 169 reported the in situ generation of complexes Mn63 , Mn65 , and Mn66 from the corresponding chiral ligands and Mn(CO) 5 Br (Table 9, entries 4, 6 and 7), respectively. The catalysts performed similarly, and the ee values of the products ranged from 18–99% ee.…”

Methanol as a Potential Hydrogen Source for Reduction Reactions Enabled by a Commercial Pt/C Catalyst

“…Catalytic reduction reactions play a pivotal role in accessing fine and bulk chemicals including pharmaceutical drugs, agrochemicals, biomolecules, and other daily life products. , Among these reactions, catalytic transfer hydrogenations (CTH) have been widely used in both academia and industry to reduce a variety of functional compounds in a selective and efficient manner. − CTH reactions have garnered significant attention in organic synthesis because of their operational simplicity and avoiding the use of special equipment as well as sluggish molecular hydrogen activation dynamics. In addition, these reactions play roles in energy technologies , and biochemical processes. , CTH processes are often performed using isopropanol and formic acid, as well as borohydrides, and silicohydrides or ammonia boranes as hydrogen donors. − , Interestingly, in recent years, bio-alcohols (methanol, ethanol, n -butanol, and others) have also emerged as potential transfer hydrogenating agents for selected transformations. ,− Transfer hydrogenations using alcohols as the hydrogen donor are of growing interest due to their specific advantages such as follows: 1) alcohols are less toxic, inexpensive, and easily accessible, 2) alcohols can be used as both solvents and hydrogen donors, 3) alcohols are stable and convenient to handle, and 4) alcohols do not produce any hazardous waste or byproducts during their reactions.…”

“…10,11 CTH processes are often performed using isopropanol and formic acid, as well as borohydrides, and silicohydrides or ammonia boranes as hydrogen donors. [12][13][14][15][16][17][18][19][20][21]75 Interestingly, in recent years, bio-alcohols (methanol, ethanol, nbutanol, and others) have also emerged as potential transfer hydrogenating agents for selected transformations. 9,22−24 Transfer hydrogenations using alcohols as the hydrogen donor are of growing interest due to their specific advantages such as follows: 1) alcohols are less toxic, inexpensive, and easily accessible, 2) alcohols can be used as both solvents and hydrogen donors, 3) alcohols are stable and convenient to handle, and 4) alcohols do not produce any hazardous waste or byproducts during their reactions.…”