Manganese-catalyzed dehydrogenative Csp³–Csp² coupling of imidazo[1,2-a]pyridines with methyl ketones

Abstract

A Mn (II)-catalyzed efficient C−H alkylation of imidazoheterocycles with methyl ketones has been developed via dehydrogenative C(sp3)-C(sp2) coupling which can serve as a novel approach toward hydrocarboxylated imidazolopyridines. The merit...

Synthesis and site selective C–H functionalization of imidazo-[1,2-a]pyridines

“…This technique offers a viable path for the highly regioselective activation of imidazopyridines that results in acetylated imidazopyridines 80 , which might have several uses in the production of pharmaceuticals (Scheme 31). 82…”

“…This technique offers a viable path for the highly regioselective activation of imidazopyridines that results in acetylated imidazopyridines 80, which might have several uses in the production of pharmaceuticals (Scheme 31). 82 Rode and his co-workers have reported the methylene (-CH 2 ) tethered aryl-sulphonation and benzotriazolation of imidazopyridines 83, employing imidazopyridine 81, arylsulfinate or benzotriazole 82 and selectfluor activated dimethyl sulphoxide (DMSO), where the solvent provides one carbon insertion during the reaction. The method was also extended to the methylene(-CH 2 ) tethered arysulphonation and benzotriazolation of beta napthols.…”

One‐Pot Synthesis of C3‐Alkylated Imidazopyridines from α‐Bromocarbonyls under Photoredox Conditions

“…Traditional processes involved the construction [6] of imidazo[1,2‐ a ]pyridines and their C3‐ [7a–e] or C5‐ [7f] functionalization. For example, a classic route to synthesize zolpidem involved seven steps (Scheme 1).…”