Manganese Exposure and Neurologic Outcomes in Adult Populations

Martin, Kaitlin Vollet; Edmondson, David; Cecil, Kim M.; Bezi, Cassandra; Vance, Miriam Leahshea; McBride, Danielle; Haynes, Erin N.

doi:10.1016/j.ncl.2020.07.008

Cited by 22 publications

(8 citation statements)

References 88 publications

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“…In the field of environmental epidemiology, MRI plays a critical role in elucidating biological mechanisms underlying Mn neurotoxicity. Until recently, the use of brain imaging in environmental health studies of Mn neurotoxicity has focused on structural brain abnormalities, primarily in the basal ganglia, and mostly targeted highly exposed workers ( 66 , 67 ). Numerous structural basal ganglia abnormalities have been reported in workers exposed to Mn, including T1 hyperintensities ( 68 , 69 , 70 , 71 ), lower apparent diffusion coefficient ( 68 ), higher pallidal index ( 72 , 73 ), and lower fractional anisotropy ( 74 , 75 , 76 ).…”

Section: Discussionmentioning

confidence: 99%

Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence

Rechtman

Navarro

Water

et al. 2023

Biological Psychiatry Global Open Science

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Section: Discussionmentioning

confidence: 99%

Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence

Rechtman

Navarro

Water

et al. 2023

Biological Psychiatry Global Open Science

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“…However, prolonged welding duration and increased exposure levels may induce neurotoxic alterations in the substantia nigra, a pathological locus implicated in PD [18]. According to Martin et al unlike Parkinson's disease (PD), manganese-induced Parkinsonism may result from impaired (too low) dopamine release [19]. PET/SPECT are used to differentiate idiopathic Parkinson's disease (IPD) from manganese-induced Parkinsonism (in the latter, PET is normal) [20].…”

Section: Factory Workers Miners and Weldersmentioning

confidence: 99%

Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations

Majewski,

Piwko,

Ordak

et al. 2024

JCM

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In recent years, a series of articles has been published concerning magnetic resonance imaging (MRI) studies in a group of patients exposed to manganism, specifically factory workers, welders, and individuals with liver diseases, as well as those abusing home-produced ephedrone. Some potential symptoms of manganese toxicity include motor disturbances, neurocognitive problems, sleep disorders, and psychosocial changes. Despite various publications on MRI research in individuals with an elevated risk of manganism, there is a noticeable absence of a comprehensive review in this field. The detection of the accumulation of manganese in the brain through MRI can confirm the diagnosis and guide appropriate treatment. Due to the high cost of determining manganese ion levels in biological material, an additional aim of the manuscript was to identify simple medical laboratory parameters that, when performed concurrently with MRI, could assist in the diagnosis of manganism. Among these types of parameters are the levels of bilirubin, magnesium, liver enzymes, creatinine, hemoglobin, and hematocrit.

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“…According to the results of previous animal studies, Mn can alter lymphocytes and other physiological variables as well as enhance susceptibility to infection on both the inner and exterior parts of the Toxics 2023, 11, 659 2 of 11 body [11][12][13][14]. The majority of research involving the effects of Mn on human health has focused on its neurologic impacts and found small neurologic abnormalities related to blood Mn levels [15]. Epidemiological research has linked high occupational exposure to Mn to a reduction in T-lymphocyte numbers, but only in adult men [16].…”

Section: Introductionmentioning

confidence: 99%

Independent and Combined Associations of Blood Manganese, Cadmium and Lead Exposures with the Systemic Immune-Inflammation Index in Adults

Zhong

Zhou

Lin

et al. 2023

Toxics

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Manganese (Mn), cadmium (Cd) and lead (Pb) have toxic effects on the immune system. However, their independent and combined effects on immune-inflammation responses are unclear. In recent years, the systemic immune-inflammation index (SII) has been developed as an integrated and novel inflammatory indicator. A retrospective cross-sectional study of 2174 adults ≥20 years old from the National Health and Nutrition Examination Survey (NHANES) 2015–2016 was conducted. Generalized linear models were used to evaluate the independent and combined associations of SII with blood Mn, Cd and Pb levels. As continuous variables, both blood Cd and Mn showed dose-dependent relationships with the SII before and after adjusting for all potential confounding factors. Metal concentrations were then converted into categorical variables. Compared with the adults in the lowest Cd or Mn tertile, those in the highest tertile had higher risks of elevated SII. Furthermore, co-exposure to Mn and Cd also showed a positive relationship with the SII after adjusting for all confounding factors. However, the single effect of Pb exposure and the joint effect of Pb and other metal exposures on the SII were not observed. This study provides important epidemiological evidence of the associations of SII with single and co-exposure effects of blood Mn, Cd, and Pb.

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Manganese Exposure and Neurologic Outcomes in Adult Populations

Cited by 22 publications

References 88 publications

Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence

Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence

Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations

Independent and Combined Associations of Blood Manganese, Cadmium and Lead Exposures with the Systemic Immune-Inflammation Index in Adults

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