Manganese levels in newborns’ hair by maternal sociodemographic, dietary and environmental factors

Irizar, Amaia; Gil, Fernando; Lertxundi, Aitana; Martín-Domingo, M. Concepción; Urbieta, Nerea; Molinuevo, Amaia; Ibarluzea, Jesús; Basterrechea, Mikel; Aurrekoetxea, Juan José; Jiménez-Zabala, Ana; Santa‐Marina, Loreto

doi:10.1016/j.envres.2018.11.038

Cited by 8 publications

(6 citation statements)

References 62 publications

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“…In the human body, the influence of the environment, nutritional status, or metabolism of heavy metals could be reflected by detecting the biomarkers present in the blood, tissue, skin, and nails ( 16 – 20 ). In this review, population, exposure, comparator, and outcome (“PECO”) approach has been used to analyze the relationship between different heavy metals and BC ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

et al. 2022

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IntroductionHeavy metals were classified as essential, probably essential, and potentially toxic in the general population. Until now, it has been reported inconsistently on the association between heavy metals and BC. In this meta-analysis, we aimed to assess the association between heavy metals and BC and review the potential mechanisms systematically.MethodsWe searched for epidemiological studies in English about the association between heavy metals and BC published before September 2020 in PubMed, Web of Science, and Embase databases. In total 36 studies, comprising 4,151 individuals from five continents around the world were identified and included.ResultsIn all biological specimens, Cu, Cd, and Pb concentrations were higher, but Zn and Mn concentrations were lower in patients with BC than in non-BC participants [SMD (95% CIs): 0.62 (0.12, 1.12); 1.64 (0.76, 2.52); 2.03 (0.11, 3.95); −1.40 (−1.96, −0.85); −2.26 (−3.39, −1.13); p = 0.01, 0.0003, 0.04, <0.0001, <0.0001]. Specifically, higher plasma or serum Cu and Cd, as well as lower Zn and Mn, were found in cases [SMD (95% CIs): 0.98 (0.36, 1.60); 2.55 (1.16, 3.94); −1.53 (−2.28, −0.78); −2.40 (−3.69, −1.10); p = 0.002, 0.0003, <0.0001, 0.0003]; in hair, only lower Zn was observed [SMD (95% CIs): −2.12 (−3.55, −0.68); p = 0.0004]. Furthermore, the status of trace elements probably needs to be re-explored, particularly in BC. More prospective studies, randomized clinical trials, and specific pathogenic studies are needed to prevent BC. The main mechanisms underlying above-mentioned findings are comprehensively reviewed.ConclusionFor BC, this review identified the current knowledge gaps which we currently have in understanding the impact of different heavy metals on BC.Systematic Review Registrationwww.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020176934, identifier: CRD42020176934.

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Section: Introductionmentioning

confidence: 99%

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

et al. 2022

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“…From recruitment to the 4 years old follow up stage there was a 10.65% of participants lost (n = 68) due to: foetal death (n = 4), miscarriage (n = 10), death (n = 2), withdrew (n = 44) and contact lost (n = 8). Of the 612 births, hair samples were collected in 437 newborns (Irizar et al, 2019). Of the 394 children who had a valid neuropsychological evaluation at 4 years of age, 304 also had information on Mn levels in their hair at birth.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…The analysis was carried out in the Department of Legal Medicine and Toxicology of the University of Granada [36][37][38]. The method has been reported in detail by Irizar et al [19].…”

Section: Manganese In Hairmentioning

confidence: 99%

“…Despite many studies having analyzed the association between prenatal Mn levels and longer-term neurodevelopment, there is little consistency in the results [23]. Therefore, after having characterized intrauterine Mn exposure, using Mn levels in newborns' hair as a biomarker of prenatal exposure [19] and considering the high vulnerability of the developing brain, in the present study, we sought to assess whether newborns' hair Mn levels are associated with neuropsychological development at 4 years of age. Further, we investigated the linearity of the association and possible sex differences.…”

Section: Introductionmentioning

confidence: 99%

“…Lastly, tobacco smoke also plays a role as a source of Mn [8], because of the high Mn concentrations in all green leaves [18], and the presumably high absorption of Mn in the lungs. Mothers who smoke have been shown to have increased Mn concentrations in umbilical cord blood [19].…”

Section: Introductionmentioning

confidence: 99%

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Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort

Andiarena

Irizar

Molinuevo

et al. 2020

IJERPH

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Background: Manganese (Mn) is an essential micronutrient for humans, the diet being the main source of exposure. Some epidemiological studies describe a negative association between prenatal Mn and later neuropsychological development, but results are inconsistent. The aim of this study was to explore the association between prenatal Mn exposure and neuropsychological development assessed at 4 years of age. Methods: Study subjects were 304 mother-child pairs from the Gipuzkoa cohort of the INMA (Environment and Childhood) Project. Mn was measured in newborns’ hair. Children’s neuropsychological development was assessed at 4 years of age using the McCarthy Scales of Children’s Abilities. Multivariate linear regression models were built. Stratified analysis by sex was performed. Generalized additive models were used to assess the shape of the relation. Results: The median Mn concentration in newborns’ hair was 0.42 μg/g (95% CI = 0.38, 0.46). The association between Mn levels and the neuropsychological development was not statistically significant for the general cognitive scale (β [95% CI] = 0.36 [−5.23, 5.95]), motor scale (β [95% CI] = 1.9 [−3.74, 7.55]) or any of the other outcomes. No sex-specific pattern was found. The best shape describing the relationship was linear for all the scales. Conclusion: Our results suggest that prenatal Mn concentrations measured in newborns’ hair do not affect cognitive or motor development at 4 years of age in boys or in girls at the observed Mn levels.

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Fetal exposure to organic contaminants revealed by infant hair: A preliminary study in south China

Cai

Tang

Zheng

et al. 2023

Environmental Pollution

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Manganese levels in newborns’ hair by maternal sociodemographic, dietary and environmental factors

Cited by 8 publications

References 62 publications

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis

Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort

Fetal exposure to organic contaminants revealed by infant hair: A preliminary study in south China

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