Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models

Feng, Sitong; Wang, Zhenzhen; Yuan, Yu‐He; Sun, Haixiang; Chen, Nai‐Hong; Zhang, Yi

doi:10.1016/j.phrs.2019.104336

Cited by 69 publications

(49 citation statements)

References 145 publications

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Section: Biological Activitiessupporting

confidence: 93%

“…In addition, the compound did not show toxicity at all the tested concentrations. The findings in this study were in line with earlier reports on the protective effects of mangiferin against PD [20]. N-trans-Feruloyl tyramine (5) showed a recognizable neuroprotective potential at 100 µM with a 60.9 ± 2.5% cell survival (6-OHDA: 48.4 ± 3.3% at 100 µM).…”

Section: Biological Activitiessupporting

confidence: 92%

“…In fact, this compound has been reported to possess a wide range of pharmacological activities [27]. It has been hypothesized that mangiferin exerts its multiple biological activities, including neuroprotective effects, through its antioxidant property [20]. In a recent study, mangiferin showed synergistic antidiabetic effects with the oral hypoglycemic drugs metformin and gliclazide [28].…”

Section: Biological Activitiesmentioning

confidence: 99%

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Constituents of Huberantha jenkinsii and Their Biological Activities

et al. 2020

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The phytochemical investigation of Huberantha jenkinsii resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the known compounds were identified as allantoin, oxylopinine, N-trans-feruloyl tyramine, N-trans-p-coumaroyl tyramine, and mangiferin. The structure determination was accomplished by spectroscopic methods. To evaluate therapeutic potential in diabetes and Parkinson’s disease, the isolates were subjected to assays for their α-glucosidase inhibitory activity, cellular glucose uptake stimulatory activity, and protective activity against neurotoxicity induced by 6-hydroxydopamine (6-OHDA). The results suggested that mangiferin was the most promising lead compound, demonstrating significant activity in all the test systems.

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Section: Biological Activitiessupporting

confidence: 93%

Section: Biological Activitiessupporting

confidence: 92%

Section: Biological Activitiesmentioning

confidence: 99%

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Constituents of Huberantha jenkinsii and Their Biological Activities

et al. 2020

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“…However, the phenolic content does not differ substantially between the different extracts to provide an explanation to our findings. In fact, mangiferin, shown to have beneficial effects in in vitro and in vivo models of neurodegeneration, as well as of oxidative stress [ 38 – 43 ], was lowest in the C. subternata water extract and highest in the 70% ethanolic extract of C. genistoides . According to these studies, we expected that the C. genistoides 70% ethanolic extract would exert the most potent neuroprotective properties, while the aqueous extract of C. subternata would exert the least.…”

Section: Discussionmentioning

confidence: 99%

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

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et al. 2020

Oxidative Medicine and Cellular Longevity

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Mitochondrial dysfunction plays a major role not only in the pathogenesis of many oxidative stress or age-related diseases such as neurodegenerative as well as mental disorders but also in normal aging. There is evidence that oxidative stress and mitochondrial dysfunction are the most upstream and common events in the pathomechanisms of neurodegeneration. Cyclopia species are endemic South African plants and some have a long tradition of use as herbal tea, known as honeybush tea. Extracts of the tea are gaining more scientific attention due to their phenolic composition. In the present study, we tested not only the in vitro mitochondria-enhancing properties of honeybush extracts under physiological conditions but also their ameliorative properties under oxidative stress situations. Hot water and ethanolic extracts of C. subternata, C. genistoides, and C. longifolia were investigated. Pretreatment of human neuroblastoma SH-SY5Y cells with honeybush extracts, at a concentration range of 0.1-1 ng/ml, had a beneficial effect on bioenergetics as it increased ATP production, respiration, and mitochondrial membrane potential (MMP) after 24 hours under physiological conditions. The aqueous extracts of C. subternata and C. genistoides, in particular, showed a protective effect by rescuing the bioenergetic and mitochondrial deficits under oxidative stress conditions (400 μM H2O2 for 3 hours). These findings indicate that honeybush extracts could constitute candidates for the prevention of oxidative stress with an impact on aging processes and age-related neurodegenerative disorders potentially leading to the development of a condition-specific nutraceutical.

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“…Mangiferin, the main constituent of Mangifera indica, has been reported to possess antioxidant, anti-inflammatory, immunomodulation and anti-apoptosis activities. Since mangiferin can cross the blood-brain barrier, it can potentially modulate the damage caused by chemotherapy in brain as well as the periphery (19). Centella asiatica contains a triterpenoid called asiatic acid.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of Mulmina™ against chemotherapy‑induced cognitive decline in normal rats

et al. 2020

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The aim of the present study was to evaluate a marketed formulation against chemotherapy-induced cognitive dysfunction. The formulation, Mulmina™, contains natural compounds which are known to help in improving function as well as in preventing cognitive decline. All of the phytoconstituents in the formulation have been tested individually but this is the first study where such a formulation has been evaluated against chemotherapy-induced cognitive decline (CICD) in a mouse model. CICD was induced by cyclophosphamide (50 mg/kg), methotrexate (5 mg/kg), and 5-fluorouracil (5 mg/kg) (CMF), administered intraperitonially. CMF was administered in three cycles, with one injection per week for three weeks. The decline in cognition of the mice was evaluated by a test of locomotor activity (Open Field Test) followed by a test for spatial memory (Morris Water Maze). Biochemical parameters evaluated include brain cytokine levels and BDNF levels via ELISA. Hematological counts were also performed to evaluate any changes in blood profile using a veterinary blood cell counter. Levels of oxidative stress markers with respect to catalase activity and lipid peroxidation were also evaluated in the brain using UV-spectrophotometric analysis. Mulmina™ was able to show significant improvement in cognitive function post chemotherapy when compared to the untreated animals. Apart from improvement in spatial memory, there was also an improvement in biochemical parameters. The particular combination of phytochemicals in Mulmina™ proved themselves successful in alleviating the CICD in this preliminary study and pave a path for future studies which can establish the solid grounds with respect to molecular and pharmacological basis for the mechanism of action of Mulmina™.

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Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models

Cited by 69 publications

References 145 publications

Constituents of Huberantha jenkinsii and Their Biological Activities

Constituents of Huberantha jenkinsii and Their Biological Activities

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

Neuroprotective effect of Mulmina™ against chemotherapy‑induced cognitive decline in normal rats

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Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models

Cited by 69 publications

References 145 publications

Constituents of Huberantha jenkinsii and Their Biological Activities

Constituents of Huberantha jenkinsii and Their Biological Activities

Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury

Neuroprotective effect of Mulmina&trade; against chemotherapy‑induced cognitive decline in normal rats

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Product

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Neuroprotective effect of Mulmina™ against chemotherapy‑induced cognitive decline in normal rats