Mangiferin and mangiferin-containing leaf extract from Mangifera foetida L for therapeutic attenuation of experimentally induced iron overload in a rat model

Estuningtyas, Ari; Wahyuni, Tri; Wahidiyat, Pustika Amalia; Poerwaningsih, Ernie Hernawati; Freisleben, Hans-Joachim

doi:10.15171/jhp.2019.04

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…[ 60 ] It is relevant to cite herein that ethanolic extract of M. indica leaves of China reported to be contained more than 60% mangiferin, a types of phenolic compounds. [ 61 ] Also, it reported that extracts of mango leaves and mangiferin compound showed good iron‐chelating effects, [ 62 ] and hence the iron‐complexing ability of the methanol extract of M. indica leaves of Nepal origin is expected to be potent for the formation of protective passive film on the surface of steel rods embedded in concrete.…”

Section: Resultsmentioning

confidence: 99%

Comparative Studies on the Anti‐Corrosive Action of Waterproofing Agent and Plant Extract to Steel Rebar

Somai

Giri

Roka

et al. 2023

Macromolecular Symposia

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Reinforcement of steel rebar in concrete infrastructure practices for a long time, mostly to improve tensile strength as well their service time. However, shortcomings related to damage of reinforced concrete (RfC) infrastructures becomes the business of corrosion researchers over the past few years, primarily from a safety and economic perspective. In general, the steel‐reinforced concrete (SRC) infrastructures are porous, and thence water as well different atmospheric pollutant gases penetrate it, causing the corrosion damages of the rebar, which shorten the prolonged existence of the RfC structures. The research aims to differentiate the efficacy and prosperity of waterproofing chemicals and methanol extract of Mangifera indica plant leaves for controlling the RfC susceptibility using a half‐cell corrosion potential measurement method following ASTM standard. The methanolic extract of M. indica leaves and waterproofing agents show high anti‐corrosion characteristics and can prescribe for the protection of the RfC infrastructures. The corrosion controlling performance level of 1000 and 2000 ppm M. indica extracts on the steel rebars in concrete has higher than the additions of alike concentration of both the water‐repellents depend on open‐circuit corrosion potential (CoP) shifting values to a noble direction.

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Section: Resultsmentioning

confidence: 99%

Comparative Studies on the Anti‐Corrosive Action of Waterproofing Agent and Plant Extract to Steel Rebar

Somai

Giri

Roka

et al. 2023

Macromolecular Symposia

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“…Medicinal plant usually have mul-tifunction properties [22][23][24][25][26][27][28]. The shortcomings of the current treatments can be completed by medicinal plants which not only are able to target multiple organs of the body but also can reduce their toxic effects [29][30][31][32][33]. Most laxative medicinal plants have substances such as anthraquinones which stimulate the intestines.…”

Section: Discussionmentioning

confidence: 99%

Constipation: An ethno-botanical study of medicinal plants used for constipation in Shahrekord city, Chaharmahal & Bakhtiari province, Iran

Karami

Karimi

Bahmani

2020

Plant Biotechnol Persa

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Constipation is a common gastrointestinal problem in society, both in children and in adults, which imposes stupendous costs on society. For centuries, people have used medicinal plants, herbal teas, and teas to relieve digestive problems, including to stimulate the digestive system and reduce constipation. Therefore, in this study we sought to investigate the indigenous and ethnobotanical knowledge regarding constipation in children and infants in Sharekord. The present ethnobotanical study was carried out through a questionnaire in Shahrekord. This study was conducted from April 2017 to February 2018 through face-to-face interviews and a questionnaire among 29 traditional therapists. The results of this study showed that medicinal plants such as Descurainia sophia (L.

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“…The iron overload and treatment groups received an intraperitoneal injection of 0.75 mL of iron sucrose containing 15 mg of elemental iron every 3-4 days for 8 weeks, for a total dose of 225 mg/rat. After being injected with iron sucrose for 3 weeks to induce iron overload condition (Estuningtyas, Wahyuni, et al, 2019), the treatment group received either deferiprone 462.5 mg/kg BW (D), mangiferin 50 mg/kg BW (M), mahkota dewa fruit extract 100 mg/kg (PM1) and 200 mg/kg BW (PM2) orally once a day for 28 days. At the end of the study, all rats were anesthetized (ketamine-xylazine) and euthanized exsanguination via cardiac puncture.…”

Section: Animal Treatmentsmentioning

confidence: 99%

Hematological Profile of Iron Overload in Rats Administered with Fruit Extract of Mahkota Dewa (Phaleria macrocarpa)

Verna

Estuningtyas

2022

JFG

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Background: Repeated blood transfusions lead to an accumulation of iron that exceeds the body's iron storage capacity. Free iron is able to catalyze the formation of hydroxyl radicals that cause oxidative damage and cell death. The use of iron chelating medicines for iron chelation therapy is limited by side effects. Mangiferin is a natural bioactive compound with iron chelating and antioxidant activity. Mahkota dewa is a plant native to Indonesia that contains mangiferin. Objectives: The aim of this study was to evaluate the effect of mahkota dewa fruit extract administration on hematological profile of iron overload rats. Material and Methods: Thirty rats were divided into 6 groups: normal rats (N), iron overload rats (IO), iron overload rats rats given deferiprone (D), mangiferin (M), Mahkota dewa fruit extract at a dose of 100 mg/kg BW (PM1), or 200 mg/kg BW (PM2). Rats were given injection of iron sucrose 15 mg every 3-4 days for 8 weeks. At week 8, rats were sacrificed. Hematological analysis was performed in this study. Results: Iron overload condition caused by iron sucrose injection did not cause statistically significant changes in the haematological profile. Likewise, the administration mahkota dewa fruit extract at a dose of 100 or 200 mg/kg BW did not cause changes in the hematological profile. Conclusions: The administration of mahkota dewa fruit extract did not alter hematological profile of iron oveload rats.

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Mangiferin and mangiferin-containing leaf extract from Mangifera foetida L for therapeutic attenuation of experimentally induced iron overload in a rat model

Abstract: Mangiferin and mangiferin-containing extracts from Mangifera foedita leaves are potent candidates as antioxidant iron chelators in the management of iron-overloaded thalassemia patients and may help to lower the costs of their treatment.

Cited by 5 publications

References 17 publications

Comparative Studies on the Anti‐Corrosive Action of Waterproofing Agent and Plant Extract to Steel Rebar

Comparative Studies on the Anti‐Corrosive Action of Waterproofing Agent and Plant Extract to Steel Rebar

Constipation: An ethno-botanical study of medicinal plants used for constipation in Shahrekord city, Chaharmahal & Bakhtiari province, Iran

Hematological Profile of Iron Overload in Rats Administered with Fruit Extract of Mahkota Dewa (Phaleria macrocarpa)

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