Mangiferin nanoemulsions in treatment of inflammatory disorders and skin regeneration

Pleguezuelos-Villa, María; Nácher, Amparo; Hernández, M. J.; Busó, M.A. Ofelia Vila; Saurı́, Ana; Dı́ez-Sales, Octavio

doi:10.1016/j.ijpharm.2019.04.056

Cited by 40 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the structure modification increased the water solubility of the MG to some extent, there were potential risks of high production cost, low conversion rate and unclear metabolism in vivo. Additionally, in terms of solubilization technologies, some new formulations of the MG have been developed, such as nanoemulsions [12], phospholipid complex [13,14], cyclodextrin inclusion complex [15] and liposome [16,17], and so on. These solubilization methods had improved the dissolution and bioavailability of the MG a certain extent, but there were still problems such as large amount of excipients and low drug loading, which might lead to potential toxicity problems of excipients.…”

Section: Introductionmentioning

confidence: 99%

Solubility, Antioxidation, and Oral Bioavailability Improvement of Mangiferin Microparticles Prepared Using the Supercritical Antisolvent Method

Liu

Ge³

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

In view of the poor water solubility and low oral bioavailability of mangiferin (MG), in this study, the supercritical antisolvent (SAS) technology was used to prepare mangiferin microparticles (MG MPs) with N,N-dimethylformamide (DMF) as solvent and carbon dioxide as antisolvent, so as to improve its water solubility, antioxidant capacity and oral bioavailability. Four factors affecting the solubility of the MG MPs were investigated by orthogonal design (OAD), including precipitation pressure, precipitation temperature, MG concentration and feeding speed, and the optimal preparation conditions were determined by range and variance analysis (ANOVA). Under the optimal conditions, the spherical MG MPs with an average diameter of 532.8 nm was obtained, and the yield of the powder was about 95.3%. Scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), X-Ray Diffractometry (XRD), differential scanning calorimetry (DSC), and thermal gravimetric (TG) were used to analyze the characteristics of the MG MPs. The results obtained showed that the chemical structure of the MG did not change before and after supercritical crystallization, but its particle size and crystallinity decreased significantly. The MG MPs had a higher solubility, and was about 4.26, 2.1 and 2.5 times than that of free MG in water, artificial gastric juice (AGJ) and artificial intestinal juice (AIJ), respectively. The dissolution rate of the MG MPs were also obviously higher than that of free MG. Furthermore, the bioavailability of the MG MPs in vivo was about 2.07 times higher than that of the free MG, and its antioxidant capacity was also much higher than that of free MG, which was close to vitamin C.

show abstract

Section: Introductionmentioning

confidence: 99%

Solubility, Antioxidation, and Oral Bioavailability Improvement of Mangiferin Microparticles Prepared Using the Supercritical Antisolvent Method

Liu

Ge³

et al. 2020

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…In order to better investigate the differences in diffusion behavior of MG from the vesicular nanosystems, the amount of drug retained in the donor compartment of the diffusion cell and in the membrane after 6 h was evaluated [ 33 ]. In all cases, the amount of MG retained by the nylon membrane (Rm) was negligible with respect to MG diffused through the membrane or residual in the vehicle.…”

Section: Resultsmentioning

confidence: 99%

“… D = F/[MG] where D is the diffusion coefficient, F is the flux, and [MG] is the MG concentration in the analyzed form, expressed in mg/mL. The concentrations of MG retained in the vehicles (Rv) and in the membrane (Rm) at the end of the diffusion experiments were also quantified [ 33 ]. Namely, 100 μL aliquots of vehicle were withdrawn, diluted with ethanol (1:10, v / v ), maintained under magnetic stirring for 30 min, and analyzed by HPLC after filtration.…”

Section: Methodsmentioning

confidence: 99%

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation

et al. 2021

View full text Add to dashboard Cite

Human skin is dramatically exposed to toxic pollutants such as ozone. To counteract the skin disorders induced by the air pollution, natural antioxidants such as mangiferin could be employed. A formulative study for the development of vesicular systems for mangiferin based on phosphatidylcholine and the block copolymer pluronic is described. Plurethosomes were designed for mangiferin transdermal administration and compared to ethosome and transethosome. Particularly, the effect of vesicle composition was investigated on size distribution, inner and outer morphology by photon correlation spectroscopy, small angle X-ray diffraction, and transmission electron microscopy. The potential of selected formulations as vehicles for mangiferin was studied, evaluating encapsulation efficiency and in vitro diffusion parameters by Franz cells. The mangiferin antioxidant capacity was verified by the 2,2-diphenyl-1-picrylhydrazyl assay. Vesicle size spanned between 200 and 550 nm, being influenced by phosphatidylcholine concentration and by the presence of polysorbate or pluronic. The vesicle supramolecular structure was multilamellar in the case of ethosome or plurethosome and unilamellar in the case of transethosome. A linear diffusion of mangiferin in the case of ethosome and transethosomes and a biphasic profile in the case of plurethosomes indicated the capability of multilamellar vesicles to retain the drug more efficaciously than the unilamellar ones. The antioxidant and anti-inflammatory potential effect of mangiferin against pollutants was evaluated on 3D human skin models exposed to O3. The protective effect exerted by plurethosomes and transethosomes suggests their possible application to enhance the cutaneous antioxidant defense status.

show abstract

“…In the pulp, up to 3.89 µg·g −1 DW was quantified, which is lower than reported by Rumainum et al (2018) [ 36 ] in the pulp of different mango cultivars from Thailand (up to 670 µg·g −1 DW). Finally, the yield of mangiferin (5.90 to 22.19 µg·g −1 DW and 0.33 to 0.78 µg·g −1 DW in the peels and pulps, respectively), a xanthone glycoside with possible applications in auto-immune diseases (e.g., psoriasis, rheumatoid arthritis and dermatitis) [ 37 ], was lower than the results presented by Vithana et al (2019) [ 34 ] in the pulp (13 µg·g −1 DW) and in the peel (194 µg·g −1 ) of the mango “Kensington Pride” in the extracts obtained with 80% methanol. Overall, it could be observed that the variety “Kent” exceled in the concentration of mangiferin as compared with the other varieties.…”

Section: Resultsmentioning

confidence: 99%

Supercritical CO2 Extraction of Bioactive Compounds from Mango (Mangifera indica L.) Peel and Pulp

Villacís-Chiriboga

Voorspoels

Uyttebroek

et al. 2021

Foods

View full text Add to dashboard Cite

The potential of supercritical CO2 (SC-CO2) for the extraction of bioactive compounds from mango by-products was assessed. Carotenoid extraction was optimized using a design of experiments based on temperature (35, 55 and 70 °C), pressure (10 and 35 MPa) and co-solvent addition (0%, 10% and 20% of ethanol or acetone). Moreover, the co-extraction of phenolic acids, flavonoids and xanthonoids was evaluated in a subset of parameters. Finally, a comparison was made between SC-CO2 and a two-step organic solvent extraction of the bioactive compounds from the pulp and peel fractions of two Ecuadorian varieties. The optimal extraction temperature was found to be dependent on the bioactive type, with phenolics requiring higher temperature than carotenoids. The optimal overall conditions, focused on maximal carotenoids recovery, were found to be 55 °C, 35 MPa and 20% of ethanol. The main carotenoid was β-carotene, while phenolics differed among the varieties. The bioactive content of the peel was up to 4.1-fold higher than in the pulp fraction. Higher antioxidant activity was found in the extracts obtained with organic solvents. SC-CO2 is a promising technology for the isolation of valuable compounds from mango by-products.

show abstract

Mangiferin nanoemulsions in treatment of inflammatory disorders and skin regeneration

Cited by 40 publications

References 34 publications

Solubility, Antioxidation, and Oral Bioavailability Improvement of Mangiferin Microparticles Prepared Using the Supercritical Antisolvent Method

Solubility, Antioxidation, and Oral Bioavailability Improvement of Mangiferin Microparticles Prepared Using the Supercritical Antisolvent Method

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation

Supercritical CO2 Extraction of Bioactive Compounds from Mango (Mangifera indica L.) Peel and Pulp

Contact Info

Product

Resources

About