2017
DOI: 10.1371/journal.pone.0173028
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Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats

Abstract: Obesity-related skeletal muscle changes include muscle atrophy, slow-to-fast fiber-type transformation, and impaired mitochondrial oxidative capacity. These changes relate with increased risk of insulin resistance. Mangiferin, the major component of the plant Mangifera indica, is a well-known anti-inflammatory, anti-diabetic, and antihyperlipidemic agent. This study tested the hypothesis that mangiferin treatment counteracts obesity-induced fiber atrophy and slow-to-fast fiber transition, and favors an oxidati… Show more

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Cited by 17 publications
(8 citation statements)
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“…Mangoes are also used for various culinary purposes. Raw mangoes are sour and used in pickles and salad, while ripe mangoes are generally sweet and used in yogurt, juices, smoothies, pies, and milk shakes [1,2,8]. The purpose of this review is to provide an assessment primarily of the gastrointestinal effects of mango leaf extracts and mangiferin, the primary active constituent thereof, as well as their mechanisms of action.…”
Section: Mango and Mango Leaf Constituentsmentioning
confidence: 99%
See 1 more Smart Citation
“…Mangoes are also used for various culinary purposes. Raw mangoes are sour and used in pickles and salad, while ripe mangoes are generally sweet and used in yogurt, juices, smoothies, pies, and milk shakes [1,2,8]. The purpose of this review is to provide an assessment primarily of the gastrointestinal effects of mango leaf extracts and mangiferin, the primary active constituent thereof, as well as their mechanisms of action.…”
Section: Mango and Mango Leaf Constituentsmentioning
confidence: 99%
“…A growing body of evidence suggests the significant potential of mangiferin (2C-β-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone; molecular formula C 19 H 18 O 11 ; CAS 4773-96-0; molecular weight 422.34), a xanthone-C-glycoside present in diverse plant species, for versatile anti-inflammatory responses, potent antioxidant, radioprotective, immunomodulatory and anti-cancer properties, as well as for disease management and health benefits [8][9][10][11][12][13][14][15][16][17][18][19][20][21]. The antioxidant efficacy of mangiferin is stronger than cimmamon [1,[13][14][15][16].…”
Section: Chemistry and Structure Of Mangiferinmentioning
confidence: 99%
“…In contrast, muscle weights of the Zucker rats were clearly affected by the genotype, i.e., muscle weights were lower in the obese rats than in the lean rats, which is in line with earlier reports about obesity-related skeletal muscle changes, including muscle atrophy, a switch towards a faster contractile phenotype and impaired mitochondrial oxidative capacity [ 26 , 27 , 28 ]. The observation that anti-inflammatory interventions are capable of attenuating these deleterious skeletal muscle changes in obese Zucker rats by inhibiting inflammatory signalling pathways in skeletal muscle [ 29 ], highlights the role of obesity-associated chronic inflammation for skeletal muscle atrophy. Our findings, therefore, suggest that ecdysterone has neither anabolic nor anti-catabolic effects on skeletal muscle in Zucker rats.…”
Section: Discussionmentioning
confidence: 99%
“…Here we show that MGF upregulates SHD at both expression and activity levels in quadriceps of not only wild type mice but also, importantly, in obese and insulin resistant mice ( Figure 4 a,b and Figure 5 a). MGF was also shown to enhance SDH activity in soleus and tibialis of obese rats, and to increase SDH activity in heart of experimentally induced myocardial infarcted rats [ 40 , 41 ].…”
Section: Discussionmentioning
confidence: 99%