Mangnese-containing superoxide dismutase in blood and urine during open-heart surgery.

Usui, Akihiko; Kato, Kanefusa; Murase, M; Maeda, Masanobu; Koyama, Tomio; Tanaka, Minoru; Takeuchi, Eiji; Abe, Toshio

doi:10.1253/jcj.56.1206

Cited by 29 publications

(39 citation statements)

References 14 publications

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“…If these cells are damaged, S-100B is rapidly released, leaking into the cerebrospinal fluid and secondarily across the blood-brain barrier into the circulation. The protein is eliminated by the kidney with a biological half-life between 30 and 113 min (26,27). Continuously increasing S-100B serum levels after brain injury may reflect both early cellular damage due to impaired permeability of the blood-brain barrier (24) and delayed renal elimination.…”

Section: Introductionmentioning

confidence: 99%

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock

Mussack¹,

Briegel²,

Schelling³

et al. 2005

Clinical Chemistry and Laboratory Medicine (CCLM)

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Stress doses of hydrocortisone are known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the use of analgesia sedation during artificial ventilation. The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma. A total of 24 consecutive patients, who met the American College of Chest Physicians/Society of Critical Care Medicine criteria for septic shock, were enrolled in this prospective, randomized, double-blind, singlecenter trial. The severity of illness at recruitment was graded using the Acute Physiology and Chronic Health Evaluation II and the Simplified Acute Physiology Score II scoring systems. Multi-organ dysfunction syndrome was described by the Sepsis-related Organ Failure Assessment (SOFA) score. All patients were prospectively randomized to receive either stress doses of hydrocortisone or placebo. Hydrocortisone was started in 12 patients with a loading dose of 100 mg and followed by a continuous infusion of 0.18 mg/kg/h for 6 days. Median S-100B serum levels of the hydrocortisone group decreased from 0.32 ng/mL at study entry to 0.07 ng/mL 6 days later without significant differences compared to the placebo group. Initial IL-8 serum levels were significantly higher in the hydrocortisone group up to 12 h after study entry, and significantly decreased from 715 to 17 pg/mL at the end of the observation period. Median PMN elastase plasma levels were not affected by hydrocortisone infusion. Patients with initial S-100B *Corresponding author: Thomas Mussack, MD, Department of Surgery Innenstadt, Klinikum der Universitä t Mü nchen, Nussbaumstraße 20, 80336 Mü nchen, Germany Phone: q49-89-5160-2638, Fax: q49-89-5160-4489, E-mail: thomas.mussack@med.uni-muenchen.de serum levels )0.50 ng/mL revealed significantly higher SOFA scores up to 30 h, IL-8 serum levels up to 12 h, and PMN elastase plasma levels up to 36 h after study entry than those patients with F0.50 ng/mL. These effects were independent of the amount of fluid correction for hemodilution. Starting S-100B, IL-8 and PMN elastase values of the hydrocortisone group were within the ranges already known in patients with out-of-hospital cardiac arrest or severe traumatic brain injury. Stress doses of hydrocortisone resulted in a significant reduction in IL-8 serum, but not in S-100B serum and PMN elastase plasma concentrations in patients with hyperdynamic septic shock. For the first time, a similar extent of S-100B increase in serum of septic patients at the time of diagnosis was shown as reported for cardiac arrest or severe traumatic brain injury.

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Section: Introductionmentioning

confidence: 99%

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock

Mussack¹,

Briegel²,

Schelling³

et al. 2005

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…As s100B is excreted 100% through the kidneys, care must be taken while interpreting s100B levels in patients with renal insufficiency. However, it is known that there are no significant differences in the blood concentrations of s100B in patients with mild to moderate renal dysfunction [51,52].…”

Section: S100bmentioning

confidence: 99%

Current State and Prospects of Development of Blood-based Biomarkers for Mild Traumatic Brain Injury

Lee

Seo

et al. 2017

Brain Neurorehabil

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Highlights• There are many unresolved clinical problems about mild traumatic brain injury (mTBI) such as a low sensitivity of standard neuroimaging studies, and absence of reliable predicting models.• It is very difficult to diagnose mTBI in symptomatic patients in the absence of witnesses, clear signs of head trauma, and abnormalities on neuroimaging.• Blood proteins have great potential as diagnostic and prognostic biomarkers of mTBI.• Technological advances in the targeted proteomics are expected to realize the clinical potential of blood-based protein biomarkers. ABSTRACTThe current understanding of the pathophysiology of mild traumatic brain injury (mTBI) is, without doubt, incomplete. Nevertheless, we tried to summarize the state-of-the-art explanation of how the brain is continuously injured even after a single impact. We also reviewed the real struggle of diagnosing mTBI, which culminated in showing the potential of blood-based biomarkers as an alternative or complementary way to overcome this difficulty. Pathophysiology of mTBI is subdivided into primary and secondary injuries. Primary injury is caused by a direct impact on the head and brain. Secondary injury refers to the changes in energy metabolism and protein synthesis/degradation resulting from the biochemical cascades as follows; calcium influx, mitochondrial dysfunction, fractured microtubules, and Wallerian degeneration, neuroinflammation, and toxic proteinopathy. Since the diagnosis of mTBI is made through the initial clinical information, it is difficult and inaccurate to diagnose mTBI without the absence of a witness or sign of head trauma. Blood-based biomarkers are expected to play an important role in diagnosing mTBI and predicting functional outcomes, due to their feasibility and the recent progress of targeted proteomics techniques (i.e., liquid chromatography tandem mass spectrometry [LC-MS/MS]).

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“…[26][27][28] S100 proteini böbrekte metabolize olup idrarla atılmaktadır. [29] Yarılanma ömrü 25 dakika olan S100 proteininin eliminasyonu orta derecede renal yetmezlikten etkilenmemektedir. [30] Birçok işlevinin (nöronal ve glial büyüme, proliferasyon ve aktivasyon) olduğu düşünülen S100 proteinlerinin esas işlevi henüz tam olarak bilinmemektedir.…”

Section: Biyobelirteçlerunclassified

Neurocognitive dysfunction after cardiac surgery and biochemical markers

Öztürk¹

2013

Turk Gogus Kalp Dama

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Mangnese-containing superoxide dismutase in blood and urine during open-heart surgery.

Cited by 29 publications

References 14 publications

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock

Current State and Prospects of Development of Blood-based Biomarkers for Mild Traumatic Brain Injury

Neurocognitive dysfunction after cardiac surgery and biochemical markers

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