Mango Polyphenols and Its Protective Effects on Diseases Associated to Oxidative Stress

Sellés, Alberto J. Núñez; Villa, D.; Rastrelli, Luca

doi:10.2174/138920101603150202143532

Cited by 24 publications

(12 citation statements)

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“…MGN is a non–flavonoid compound abundant in mango fruit and its plant. It has been implicated in ameliorating various disease forms (Selles et al, ). Recently, the protective effect in annulling the toxic effects of heavy metals like mercury and lead using different in vitro model was demonstrated by various groups (Satish Rao et al, ; Das et al, ; Pal et al, ).…”

Section: Discussionmentioning

confidence: 99%

Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction

Das

Paul

Mumbrekar

et al. 2016

Environmental Toxicology

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Mangiferin (MGN), a C-glucosylxanthone abundantly found in mango plants, was studied for its potential to ameliorate methylmercury (MeHg) induced mitochondrial damage in HepG2 (human hepatocarcinoma) cell line. Cell viability experiments performed using 3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide (MTT) showed protective property of MGN in annulling MeHg-induced cytotoxicity. Conditioning the cells with optimal dose of MGN (50 µM) lowered MeHg-induced oxidative stress, calcium influx/efflux, depletion of mitochondrial trans-membrane potential and prevented mitochondrial fission as observed by decrease in Mitotracker red fluorescence, expression of pDRP1 (serine 616), and DRP1 levels. MGN pre-treated cells demonstrated elevation in the activities of glutathione (GSH), Glutathione-S-transferase (GST), Glutathione peroxidase (GPx), Glutathione reductase (GR), reduced levels of Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) and mitochondrial electron transport chain (ETC) enzyme complexes. In addition, the anti-apoptotic effect of MGN was clearly indicated by the reduction in MeHg-induced apoptotic cells analyzed by flowcytometric analysis after Annexin V-FITC/propidium iodide staining. In conclusion, the present work demonstrates the ability of a dietary polyphenol, MGN to ameliorate MeHg-mediated mitochondrial dysfunction in human hepatic cells in vitro. This hepatoprotective potential may be attributed predominantly to the free radical scavenging/antioxidant property of MGN, by facilitating the balancing of cellular Ca ions, maintenance of redox homeostasis and intracellular antioxidant activities, ultimately preserving the mitochondrial function and cell viability after MeHg intoxication. As MeHg intoxication occurs over a period of time, continuous consumption of such dietary compounds may prove to be very useful in promoting human health. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 630-644, 2017.

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Section: Discussionmentioning

confidence: 99%

Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction

Das

Paul

Mumbrekar

et al. 2016

Environmental Toxicology

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“…The fruits of Mangifera indica L. (Anacardiaceae) are known to contain high levels of bioactive compounds such as vitamins, carotenoids, and polyphenols. The occurrence of high levels of polyphenols, such as the xanthonoid mangiferin, flavonoids, phenolic acids, and different derivatives, provide a good basis for M. indica fruits as a healthy food [1]. Recently, it could be demonstrated that Careless™ activates the evolutionary conserved metabolic sensors sirtuin 1 (Sirt1) and AMP-activated protein kinase (AMPK) and, furthermore, stimulates mitochondrial biogenesis and has antioxidative effects based on an increase in superoxide dismutase activity [2].…”

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confidence: 99%

In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation

Gerstgrasser¹,

Röchter²,

Dressler

et al. 2015

Planta Med

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“…Mangiferin is a xanthone, which is present in several plant species, particularly the mango Mangifera indica. This compound has numerous biological activities, such as a protective effect against diseases associated with oxidative stress, inflammatory response and against type 2 diabetes [20,21]. Tests with mangiferin indicate a non-competitive inhibition of Ap-B with a small mixed character.…”

Section: Introductionmentioning

confidence: 99%

The effects of curcumin, mangiferin, resveratrol and other natural plant products on aminopeptidase B activity

Cadel

Darmon

Désert

et al. 2019

Biochemical and Biophysical Research Communications

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Aminopeptidase B (Ap-B) is a Zn 2þ-aminopeptidase of the M1 family which is implicated, in conjunction with the nardilysin endoprotease, in the generation of miniglucagon, a peptide involved in the maintenance of glucose homeostasis. Other in vivo physiological roles have been established for this vertebrate enzyme, such as the processing of Arg-extended forms of human insulin and cholecystokinin 9 and the degradation of viral epitopes in the cytoplasm. Among M1 family members, Ap-B is phylogenetically close to leukotriene A 4 hydrolase (LTA 4 H), a bi-functional aminopeptidase also able to transform LTA 4 in LTB 4 (a lipid mediator of inflammation). As the activities of LTA 4 H are reported to be inhibited by resveratrol, a polyphenolic molecule from red wine, the effect of this molecule was investigated on the Ap-B activity. Several other active phenolic compounds produced in plants were also tested. Among them, curcumin and mangiferin are the most effective inhibitors. Dixon analysis indicates that curcumin is a non-competitive inhibitor with a Ki value of 46 mmol.L À1. Dixon and Lineweaver-Burk representations with mangiferin show a mixed non-competitive inhibition with Ki' and Ki values of 194 mmol.L À1 and 105 mmol.L À1 , respectively. At 200 mmol.L À1 , no significant effect was observed with caffeic, chlorogenic, ferulic, salicylic and sinapic acids as well as with resveratrol. Analyses on the 3D-structure of LTA 4 H with resveratrol (pdb: 3FTS) and the Ap-B 3D-model allow hypothesis to explain theses results.

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Mango Polyphenols and Its Protective Effects on Diseases Associated to Oxidative Stress

Cited by 24 publications

References 0 publications

Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction

Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction

In Vitro Activation of eNOS by Mangifera indica (Careless™) and Determination of an Effective Dosage in a Randomized, Double-Blind, Human Pilot Study on Microcirculation

The effects of curcumin, mangiferin, resveratrol and other natural plant products on aminopeptidase B activity

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