Mango Supplementation Improves Blood Glucose in Obese Individuals

Abstract

This pilot study examined the effects of freeze-dried mango (Mangifera indica L.) supplementation on anthropometrics, body composition, and biochemical parameters in obese individuals. Twenty obese adults (11 males and 9 females) ages 20- to 50-years old, received 10 g/day of ground freeze-dried mango pulp for 12 weeks. Anthropometrics, biochemical parameters, and body composition were assessed at baseline and final visits of the study. After 12 weeks, mango supplementation significantly reduced blood glucose in both male (−4.45 mg/dL, P = 0.018) and female (−3.56 mg/dL, P = 0.003) participants. In addition, hip circumference was reduced in male (−3.3 cm, P = 0.048) but not in female participants. However, there were no significant changes in body weight or composition in either gender. Our findings indicate that regular consumption of freeze-dried mango by obese individuals does not negatively impact body weight but provides a positive effect on fasting blood glucose.

Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation

“…These metabolic changes are in agreement with a significant reduction in plasma glucose levels and hepatic carbohydrate parameters, together with benefits on hepatic lipid profiles, elicited by supplementation with mango fruit powder (5 and 10 g) in fluoride-induced metabolic toxicity previously reported in rats [36]. In addition, a pilot study in humans showed that a 12-week supplementation with freeze-dried mango significantly reduced blood glucose levels in both male and female participants [16]. …”

“…is a globally consumed fruit with reported health-promoting properties [10-13] and, based on studies in rats [14, 15] and humans [16, 17], its habitual consumption may contribute to the prevention of diabetes mellitus, obesity, and related complications. In addition, it has been reported that the food ingredient Careless TM , a 100% pure mango fruit powder characterized by a high content in secondary plant metabolites, including gallic acid, rutin and mangiferin (MGF) [18], activates sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) in cell systems [19], which are both involved in energy homeostasis and glucose and lipid metabolism.…”

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6‐Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals

“…Polyphenols from mango extracts exert anti‐cancer, anti‐inflammatory, and anti‐obesogenic effects in vitro and in animal models . In a human clinical trial, obese individuals that consumed freeze‐dried mango pulp for 12 weeks exhibited improved fasting blood glucose levels, suggesting potential health benefits for individuals with metabolic disorders.…”

Metabolic diversity and in vitro pancreatic lipase inhibition activity of some varieties of Mangifera indica L. fruits

“…In sum, 63 metabolites were identified (Table 1) by GC-MS and HPLC from the seven mango varieties. GC-MS-identified metabolites included organic acids (20), amino acids (10), fatty acids (6), phenols (8), sugar and polyols (13) and other constituents (5), detected using the Agilent Fiehn Metabolomics Library. Mangiferin was detected by HPLC.…”

“…[19] Moreover, the regular consumption of freeze-dried mango was shown to reduce fasting glucose levels in obese individuals and to possibly be able to prevent an increase in body fat. [20] The objectives of the study were (1) to explore the metabolite profiles of Indian mango varieties to identify the metabolites contributing to varietal differences and (2) to assess the lipase inhibitory property of mango fruit pulps.…”