Manifestation of eosinophilic granulomatosis with polyangiitis in head and neck

Petersen, H.; Götz, Paul; Both, Marcus; Hey, Matthias; Ambrosch, Petra; Bremer, Jan Phillip; Holle, Julia; Moosig, Frank; Laudien, Martin

doi:10.4193/rhin14.074

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…Asthma should always be assessed in patients with AR by asking patients about wheezing, shortness of breath and sleep disturbance plus, if needed, an objective measurement such as spirometry 80 and vice versa in patients with asthma owing to the frequent co-occurrence of these disorders. Patients should also undergo ear inspection as otitis media with effusion (also known as glue ear) may be a co-morbidity in children with rhinitis and in adults with severe forms of rhinosinusitis 81 . The general examination needs to also include skin examination for atopic dermatitis, and, in patients with obstructive rhinitis, assessment of thyroid function by checking for slow relaxation after the ankle jerk and for eye signs such as puffiness, redness and/or bulging, as hypothyroidism.…”

Section: Examinationmentioning

confidence: 99%

Allergic rhinitis

Bousquet

Antó

Bachert

et al. 2020

Nat Rev Dis Primers

521

385

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Section: Examinationmentioning

confidence: 99%

Allergic rhinitis

Bousquet

Antó

Bachert

et al. 2020

Nat Rev Dis Primers

521

385

View full text Add to dashboard Cite

“…ANCA positive 31%-58% 26,37 MPO ANCA positive 25%-50% 26,47 ENT involvement 48%-96% 37,38 Rhinologic CRSwNP 42%-51% 37,38 Change in sense of smell 40% 47 Nasal crusting 8%-43% 47,48 Otologic OME/CHL 3%-12% 26 59 although the importance of abstinence from cocaine for a good outcome cannot be overstated.…”

Section: Prevalence Of Ent Features Of Eosinophilic Granulomatosis Wimentioning

confidence: 99%

Updates in antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis for the ENT surgeon

Coates

Pero

2020

Clinical Otolaryngology

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ENT involvement is common in ANCA-associated vasculitis (AAV), particularly in GPA and EGPA. Early recognition and treatment is important for good outcomes, yet evidence suggests that UK ENT surgeons may not consistently recognise the early features of AAV, despite a similar incidence to vestibular schwannoma. AAV is a rapidly advancing field, with significant developments in the understanding of its pathogenesis, classification and treatment over the past decade. Relevant vasculitis mimics are also discussed with a particular focus on the increasing prevalence of vasculitis mimics driven by an increase in recreational cocaine use, as well as the emergence and reclassification of several other vasculitis mimics in the head and neck. This article reviews key recent updates in the vasculitis literature, with a particular focus on those relevant to recognition and diagnosis of AAV for the ENT surgeon. Strengths and limitations of relevant diagnostic testing are discussed, and a method of evaluation of patients with features of AAV presenting to ENT services is outlined. | 317

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“…As expected, based on the diagnostic criteria for EGPA, which includes obstructive airway disease and nasal polyps, 22 the most common manifestations for patients in the current study were asthma, chronic sinusitis, and allergic rhinitis, largely consistent with previous real-world studies. 6,7,9 Despite the frequency of manifestations, particularly the strong link to ear, nose, and throat manifestations, 23 the median DCI score for this study's population was 1.0 out of 6. Another previous administrative claims study reported the mean Quan-Charlson Comorbidity Index (CCI) score of 1.8 for patients in the EGPA cohort, which was higher than the 0.8 CCI value reported in the same study for patients in the asthma cohort.…”

Section: Discussionmentioning

confidence: 64%

Characteristics and Disease Burden of Patients With Eosinophilic Granulomatosis With Polyangiitis Initiating Mepolizumab in the United States

Silver,

Deb,

Packnett

et al. 2023

J Clin Rheumatol

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Background/Objective Although the high disease burden associated with eosinophilic granulomatosis with polyangiitis (EGPA) has been established, the disease burden in patients initiating mepolizumab in real-world practice is poorly understood. This study aimed to assess characteristics and burden of real-world patients with EGPA initiating mepolizumab. Methods This was a database study (GSK study ID: 214156) of US patients (≥12 years old) with EGPA and ≥1 mepolizumab claim (index date) identified from the Merative MarketScan Commercial and Medicare Supplemental Databases (November 1, 2015, to March 31, 2020). Outcomes assessed in the 12-month baseline period before index (inclusive) included patient characteristics, treatment use, EGPA relapses, asthma exacerbations, health care resource utilization, and costs. Results In the 103 patients included (mean age, 51.1 years; 63.1% female), the most common manifestations were asthma (89.3%), chronic sinusitis (57.3%), and allergic rhinitis (43.7%). In total, 91.3% of patients had ≥1 oral corticosteroid (OCS) claim (median dose, 7.4 mg/d prednisone-equivalent), 45.6% were chronic OCS users (≥10 mg/d during the 90 days preindex), 99.0% had ≥1 EGPA-related relapse, and 62.1% ≥1 asthma exacerbation. During the baseline period, 26.2% and 97.1% of patients had EGPA-related inpatient admissions and office visits, respectively. Median all-cause total health care costs per patient were $33,298, with total outpatient costs ($16,452) representing the largest driver. Conclusions Before initiating mepolizumab, a substantial real-world EGPA disease burden is evident for patients, with resulting impact on health care systems, and indicative of unmet medical needs. Mepolizumab treatment, with a demonstrated positive clinical benefit-risk profile may represent a useful treatment option for reducing EGPA disease burden.

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Manifestation of eosinophilic granulomatosis with polyangiitis in head and neck

Cited by 11 publications

References 38 publications

Allergic rhinitis

Allergic rhinitis

Updates in antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis for the ENT surgeon

Characteristics and Disease Burden of Patients With Eosinophilic Granulomatosis With Polyangiitis Initiating Mepolizumab in the United States

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