2020
DOI: 10.1111/coa.13524
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Updates in antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis for the ENT surgeon

Abstract: ENT involvement is common in ANCA-associated vasculitis (AAV), particularly in GPA and EGPA. Early recognition and treatment is important for good outcomes, yet evidence suggests that UK ENT surgeons may not consistently recognise the early features of AAV, despite a similar incidence to vestibular schwannoma. AAV is a rapidly advancing field, with significant developments in the understanding of its pathogenesis, classification and treatment over the past decade. Relevant vasculitis mimics are also discussed … Show more

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Cited by 8 publications
(15 citation statements)
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“…The latter is accentuated in localised GPA disease such as SGS. 2 This is echoed in our cohort with 9 ANCA-negative cases and only 23% of biopsies confirming GPA. Considering the low yield of diagnostic tests, we recommend regular clinical assessments for signs of systemic involvement and early MDT input where systemic features of GPA are recognised.…”
Section: Discussionsupporting
confidence: 53%
See 3 more Smart Citations
“…The latter is accentuated in localised GPA disease such as SGS. 2 This is echoed in our cohort with 9 ANCA-negative cases and only 23% of biopsies confirming GPA. Considering the low yield of diagnostic tests, we recommend regular clinical assessments for signs of systemic involvement and early MDT input where systemic features of GPA are recognised.…”
Section: Discussionsupporting
confidence: 53%
“…There are no diagnostic criteria for ANCA-associated vasculitis (AAV). 2 Investigative accuracy has been limited in AAV; 77% of head and neck biopsies are non-diagnostic and 10% of AAV patients being ANCA negative. The latter is accentuated in localised GPA disease such as SGS.…”
Section: Discussionmentioning
confidence: 99%
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“…Nerve palsy may occur as single or multiple cranial nerve involvement. Evolution to osteomyelitis by invasive mass is possible [70] . Parapharyngeal involvement is reported by description of a parapharyngeal mass or secondary to local extension from contiguous parotid mass.…”
Section: Tumor-like Manifestationsmentioning
confidence: 99%