2006
DOI: 10.1093/brain/awl303
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Manifestations of early brain recovery associated with abstinence from alcoholism

Abstract: Chronic alcohol abuse results in morphological, metabolic, and functional brain damage which may, to some extent, be reversible with early effects upon abstinence. Although morphometric, spectroscopic, and neuropsychological indicators of cerebral regeneration have been described previously, the overall amount and spatial preference of early brain recovery attained by abstinence and its associations with other indicators of regeneration are not well established. We investigated global and local brain volume ch… Show more

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Cited by 175 publications
(163 citation statements)
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“…SIENA has been used in a number of studies investigating changes in brain structure [Bartsch et al, 2007;Mezzapesa et al, 2007;Peters et al, 2006] and is briefly described below. The SIENA program is applied to each participant's pair of images, scanned before and after acute dehydration.…”
Section: Assessment Of Brain Volume Changementioning
confidence: 99%
See 1 more Smart Citation
“…SIENA has been used in a number of studies investigating changes in brain structure [Bartsch et al, 2007;Mezzapesa et al, 2007;Peters et al, 2006] and is briefly described below. The SIENA program is applied to each participant's pair of images, scanned before and after acute dehydration.…”
Section: Assessment Of Brain Volume Changementioning
confidence: 99%
“…To allow voxelwise statistical interrogation of the data, the mean displacement images for each participant are dilated (14 times using a 3 3 3 3 3 kernel, nonbinary dilation) and transformed into Montreal Neurological Institute (MNI) space and masked by a standard brain edge image [Bartsch et al, 2007]. The number of dilations performed is the standard number for a SIENA voxelwise analysis and provides a large enough band of flow values around the brain-CSF boundary so that the standard brain edge mask can extract values for each point on the mask.…”
Section: Assessment Of Brain Volume Changementioning
confidence: 99%
“…Not only the focal distribution of alcohol in the brain and changes in cellular metabolites such as aspartate but also the regeneration of the brain tissue under oxidative stress in the case of abstinence in chronic abuse can be dynamically detected on magnetic resonance spectroscopy and correlate with clinical recovery [48 -50]. Cerebral regeneration in the case of abstinence is reflected in a focally differentiated increase in the choline and NAA peaks [51].…”
Section: Dynamics and Reversibility Of The Changesmentioning
confidence: 99%
“…Thiamine is thought to play a role in the cholinergic synaptic transmission and axonal conduction, and an excessive alcohol intake can result in thiamine deficiency (5 (24). …”
Section: T Dec R E a S E I N Gl U C O S E Me T A B O L I S M I N F Dgmentioning
confidence: 99%