Mannitol-Induced Acute Renal Failure

Dorman, Henry R.; Sondheimer, James; Cadnapaphornchai, Phavit

doi:10.1097/00005792-199005000-00003

Cited by 168 publications

(91 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5,[11][12][13] In most cases, high-dose mannitol infusion was given. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] During mannitol infusion, hyperosmolarity was documented by most, that is, 13 reports/series while combined hyponatremia and hyperosmolarity in 8 reports/series ( (Table 2). In our patient, it was up to 0.24 kg given over 4 days (56 hours) at a rate not faster than 0.5 g/kg/h.…”

Section: Resultsmentioning

confidence: 99%

“…1,2,5,9,10 Discontinuance of mannitol has been mentioned as the primary mode of therapy in majority of reports. 11,17,26,[29][30][31][32][33][34][35][36][37] Eleven reports/series mentioned the use of dialysis with or without ultrafiltration in addition (Tsai et Table 2). Total recovery without dialysis specifically was narrated by two reports/series (Docci et al and Visweswaran et al).…”

Section: Resultsmentioning

confidence: 99%

“…Mitochondria and other cell organelles remain unchanged ( Figure 2). 1,10,11,23,25,26 Tubular vacuolization causes gradual cell swelling and may lead to narrowing but not to complete occlusion of the tubular lumens. The brush border and the basal labyrinth usually are well preserved.…”

Section: Histolopathology Characteristicsmentioning

confidence: 99%

“…By electron microscopy and enzyme histochemistry, the vacuoles were identified as lysosomes. 10,11,22,23,26,27 The sequelae of ON are unpredictable since repeat biopsies are usually not performed. In most cases, the vacuolization will completely vanish without sequelae.…”

Section: Histolopathology Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Osmotic nephrosis with mannitol: review article

et al. 2014

View full text Add to dashboard Cite

Mannitol is commonly used to lower intracranial and intraocular pressures. Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis. While many researchers have reported individual experiences with this pathology, we felt that there is need of an updated comprehensive review of all reported cases with elaboration of etiology, pathogenesis, diagnosis and management plan for MI-ARF. The purpose of the present communication is to share our own experience with MI-ARF, to review the effect of mannitol on kidney function and to highlight the dynamics of MI-ARF with considerations for the cautious use of mannitol in patients with risk factors for kidney diseases. KeywordsAcute renal failure/injury, mannitol, osmotic nephrosis, mannitol-induced acute renal failure, mannitol-induced osmotic nephrosis History

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Histolopathology Characteristicsmentioning

confidence: 99%

Section: Histolopathology Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Osmotic nephrosis with mannitol: review article

et al. 2014

View full text Add to dashboard Cite

show abstract

“…[21][22][23] The infusing rate and the total amount of mannitol are associated with renal impairment, and the factors that may reduce GFR such as old age and chronic renal insufficiency are predisposing factors of renal injury. 5,21,22 It was reported that the accumulative doses of mannitolinducing AKI in patients with normal baseline renal function was more than 1100 g, whereas less dose (less than 300 g) of mannitol could induce renal failure in patients with baseline renal disease, and daily dose of more than 200 g creating the different osmotic pressure (more than 60 Osm/kg) could easily lead to AKI. Impaired baseline renal function, using furosemide, and renal transplantation (including cyclosporine therapy) are all independent risk factors of AKI.…”

Section: Discussionmentioning

confidence: 99%

Mannitol is an independent risk factor of acute kidney injury after cerebral trauma: a case–control study

You

Chen

et al. 2010

Renal Failure

View full text Add to dashboard Cite

We retrospectively studied a random cohort of patients with cerebral trauma to investigate the risk factors of acute kidney injury (AKI) following cerebral trauma. AKI was determined using the RIFLE (risk, injury, failure, loss, or end-stage kidney) staging criteria. About 171 patients were chosen in the study, with 53 patients in AKI group and 118 patients without AKI in non-AKI group. By logistic regression analysis, univariate analysis revealed that age, hypertension, emergent surgery, systemic inflammatory response syndrome (SIRS), Glasgow coma score (GCS), sequential organ failure assessment (SOFA) score, the respiration, coagulation, and cardiovascular components of the SOFA score, mechanical ventilation time, red blood cell transfusion, plasma transfusion, and the accumulative doses of furosemide, torsemide, and mannitol were significantly related to AKI after cerebral trauma. Logistic multivariate regression analysis showed that SOFA score [odds ratio (OR) = 1.516, 95% confidence interval (CI) 1.222-1.881, p < 0.001], the accumulative doses of torsemide (OR = 0.016, 95% CI 1.002-1.031, p = 0.016), and the accumulative doses of mannitol (OR = 2.687, 95% CI 1.062-6.800, p = 0.037) were independent risk factors of AKI. This model had a good discrimination for AKI with an area under the receiver operating characteristic (ROC) curve of 0.901 (p < 0.001). The accumulative doses of mannitol as a risk factor of AKI were identified by propensity score match (PSM) method. We concluded that AKI was a common complication in patients with cerebral trauma. SOFA score and the accumulative doses of torsemide and mannitol were independent risk factors of AKI following cerebral trauma.

show abstract

Safety of Intravenous Immunoglobulin

Thornton¹

1993

Archives of Neurology

View full text Add to dashboard Cite

Mannitol-Induced Acute Renal Failure

Cited by 168 publications

References 0 publications

Osmotic nephrosis with mannitol: review article

Osmotic nephrosis with mannitol: review article

Mannitol is an independent risk factor of acute kidney injury after cerebral trauma: a case–control study

Safety of Intravenous Immunoglobulin

Contact Info

Product

Resources

About