Mannose-binding Lectin Gene Polymorphisms and Mycobacterial Lymphadenitis in Young Patients

You, Hua; Lin, Tzu-Chao; Wang, Jui-Chu; Li, Chia‐Chin; Chao, Tsi-Chian; Liao, Wei‐Ting; Eng, Hock‐Liew

doi:10.1097/inf.0b013e31829e6798

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…Further to these inconsistencies, Soborg and Selvaraj reported that low serum MBL levels could reduce tubercle bacilli infections [18,19], whilst other studies found that high of serum MBL levels [22,23] could reduce tubercle bacilli infections. Although studies have shown that Promoter -221(Y/X) mutation (YX, XX) [22] and HYB haplotype [23] could lead to decreased serum MBL [12,24] and enhanced susceptibility to TB. Liu Wei and colleagues reported that [20] the promoter -221(Y/X) mutation in the Han population was not associated with susceptibility to TB.…”

Section: Introductionmentioning

confidence: 99%

Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis

Chen

Liang

et al. 2015

BMC Infect Dis

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BackgroundMannose-binding lectin (MBL) and MBL-associated serine proteases 2 (MASP-2) are important proteins in the lectin pathway of the immune system. Polymorphism of MBL and MASP-2 genes may affect the serum concentration of MBL and MASP-2. This study explores the association between MBL and MASP-2 gene polymorphism and their interactions and the susceptibility to tuberculosis (TB).MethodA total of 503 patients with TB and 419 healthy controls were recruited to participate in this case-control study. PCR-SSP technology was applied to genotype rs7096206 of MBL genes and rs2273346 and rs6695096 of MASP-2 genes. Demographic data and some exposure information were also obtained from study participants. Unconditional logistic regression analysis was used to identify association between the various factors and TB whilst Marginal Structural Linear Odds Models were used to estimate the interactions.ResultsBoth genotype GC at rs7096206 of MBL genes and genotype TC at rs2273346 and rs6695096 of MASP-2 genes were more prevalent in the TB patient group than the healthy control group (P < 0.05, OR 1.393, 1.302 and 1.426 respectively). The relative excess risk of interaction (RERI) between rs7096206 of MBL genes and rs2273346 and rs6695096 of MASP-2 genes was 0.897 (95% CI: 0.282, 1.513) and 1.142 (95% CI: 0.755, 1.530) respectively (P < 0.05).ConclusionPolymorphisms of MBL (rs7096206) and MASP-2 (rs2273346 and rs6695096) were associated with the susceptibility of TB, and there were gene-gene interactions among them.

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Section: Introductionmentioning

confidence: 99%

Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis

Chen

Liang

et al. 2015

BMC Infect Dis

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“…Some studies have indicated that mutations in the promoter and exon 1 of MBL2 may lead to the decline of MBL expression in the serum, while lower serum MBL levels can increase infections caused by tubercle bacilli [40,54], indicating that polymorphisms in MBL2 may exert a protective effect against TB. Other studies have indicated that higher serum levels of MBL can reduce tubercle bacilli infections, which are associated with wild-type MBL2 alleles [5,27,55]. These studies suggest that MBL2 variants may increase the risk for TB.…”

Section: Discussionmentioning

confidence: 77%

Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Shen

Yang

et al. 2020

Hereditas

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Background: Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB. Methods: The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships. Results: There were 37 case-control studies examining the effects of the four SNPs in MBL2 on PTB. A positive association between rs11003125 and PTB risk was observed in the hospital-based subgroup. Moreover, for the combined polymorphism and PTB risk, positive associations were detected not only in the total population but also in those with Asian origins across all source of control subgroups. No associations were found for rs7096206 or rs7095891. Conclusions: Our current study indicated that several SNPs in MBL2 may be associated with susceptibility to PTB.

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“…In children lectin pathway deficiencies may play a role in Haemophilus influenzae [ 20 ] but this was not found in a cohort of adults with community acquired pneumonia [ 21 ]. The effect of MBL genotype on the susceptibility to Mycobacterium tuberculosis is controversial [ 22 , 23 ]. In burn injury patients [ 16 ] and cystic fibrosis patients [ 24 ] MBL deficiency plays an important role on susceptibility to Pseudomonas aeruginosa infection and colonization.…”

Section: Discussionmentioning

confidence: 99%

Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes

Bronkhorst¹,

Lieshout²

2015

TOORTHJ

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Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. There is increasing evidence for the role of genetic variation in the innate immune system on infectious complications in severe trauma patients. We describe a trauma patient with multiple infectious complications caused by multiple micro-organisms leading to prolonged hospital stay with numerous treatments. This patient had multiple single nucleotide polymorphisms (SNPs) in the MBL2, MASP2, FCN2 and TLR2 genes, most likely contributing to increased susceptibility and severity of infectious disease.

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Mannose-binding Lectin Gene Polymorphisms and Mycobacterial Lymphadenitis in Young Patients

Cited by 5 publications

References 37 publications

Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis

Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis

Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes

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