Mannose-Binding Lectin in Obesity with Different Degrees of Metabolic Syndrome Abnormalities: Association with Atherogenic and Metabolic Traits

Strack, Christina; Baessler, Andrea; Wagner, Florian Mathias; Bruxmeier, Janine; Yaroslavskii, Oleg; Rousseva, Elena; Loew, Thomas H.; Riegger, Günter A.J.; Schmitz, Gerd; Fischer, Marcus

doi:10.5551/jat.10918

Cited by 11 publications

(10 citation statements)

References 43 publications

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“…In a study of German adults not selected for IgGSD or frequent or severe respiratory tract infection, mean plasma MBL levels in severely obese and healthy, lean subjects did not differ significantly [21]. In obese German and Swedish subjects, MBL levels did not change significantly after weight loss [21, 22]. MBL mRNA is not expressed in adipose tissue [22].…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

Barton

Barton²,

Bertoli³

2019

BMC Immunol

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Background Mannose-binding lectin (MBL) deficiency may increase risk of respiratory tract infection in adults unselected for IgG or IgG subclass levels. In a retrospective study, we sought to determine associations of serum MBL levels with clinical and laboratory characteristics of unrelated non-Hispanic white adults at diagnosis of IgG subclass deficiency (IgGSD). We computed the correlation of first and second MBL levels expressed as natural logarithms (ln) in a patient subgroup. We compared these characteristics of all adults with and without MBL ≤50 ng/mL: age; sex; body mass index; upper/lower respiratory tract infection; diabetes; autoimmune condition(s); atopy; other allergy; corticosteroid therapy; and subnormal serum IgG subclasses, IgA, and IgM. We performed logistic regression on MBL ≤50 ng/mL (dichotomous) using the three independent variables with the lowest values of p in univariate comparisons. Results There were 219 patients (mean age 51 ± 13 y; 82.5% women). Thirty-six patients (16.4%) had MBL ≤50 ng/mL. Two MBL measurements were available in 14 patients. The median interval between the first and second measurements was 125 d (range 18–1031). For ln-transformed data, we observed adjusted r 2 = 0.9675; Pearson correlation coefficient 0.9849; and p < 0.0001. Characteristics of patients with and without MBL ≤50 ng/mL did not differ significantly in univariate comparisons. We performed a regression on MBL ≤50 ng/mL using: subnormal IgM ( p = 0.0565); upper respiratory tract infection ( p = 0.1094); and body mass index ( p = 0.1865). This regression revealed no significant associations. Conclusions: We conclude that the proportion of the present IgGSD patients with serum MBL ≤50 ng/mL is similar to that of healthy European adults. MBL ≤50 ng/mL was not significantly associated with independent variables we studied.

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Section: Discussionmentioning

confidence: 99%

Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

Barton

Barton²,

Bertoli³

2019

BMC Immunol

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“…The study population of the ongoing “Obesity and Weight Reduction Remodeling Study” has been described previously [13] , [14] . Control and obese subjects for the study population published here have been recruited from 03/2005 to 04/2008 at the University Hospital of Regensburg.…”

Section: Methodsmentioning

confidence: 99%

Alterations of Plasma Lysophosphatidylcholine Species in Obesity and Weight Loss

et al. 2014

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BackgroundObesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. Alterations in the metabolism of lipid classes and lipid species may significantly be involved in these metabolic overload diseases. However, little is known about specific lipid species in this syndrome and existing data are contradictive.MethodsIn this study, we quantified plasma lipid species by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in obese subjects before and after 3 month weight loss as well as in a control group.ResultsThe comparison of obese subjects with control subjects before weight loss revealed significantly lower lysophosphatidylcholine (LPC) concentrations in obesity. LPC concentrations did not significantly increase during the observed period in the weight loss group. Analysis of LPC species revealed a decrease of most species in obesity and negative correlations with C-reactive protein (CRP) and body mass index (BMI). Correlating BMI ratio before and after weight loss with the ratio of total LPC and individual LPC species revealed significant negative relationships of LPC ratios with BMI ratio.ConclusionsOur findings contribute to the contradictive discussion of the role of LPC in obesity and related chronic inflammation strongly supporting pre-existing data in the literature that show a decrease of LPC species in plasma of obese and a potentially anti-inflammatory role in these subjects.

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“…Exclusion criteria were described elsewhere. 19, 20 Healthy normal weight control subjects (BMI 20–24.9 kg m −2 ) of similar age and gender distribution were also included. They were recruited by flyers and advertisements.…”

Section: Methodsmentioning

confidence: 99%

Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects

et al. 2014

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Objectives:This study aimed to examine the association of adipocyte fatty acid-binding protein (FABP4) levels with left ventricular diastolic dysfunction (LVDD) in obese subjects with varying degrees of the metabolic syndrome (MetS).Methods:Fifty morbidly obese subjects with LVDD were selected at random and matched by age (±5 years) and sex with 50 morbidly obese with normal left ventricular (LV) function. In addition, 24 healthy lean subjects were included as controls.Results:Median FABP4 levels (interquartile range) in obese subjects with LVDD were significantly higher (42 ng ml−1 (32–53)) than in obese with normal LV function (24 ng ml−1 (36–43), P=0.036), and in normal weight controls (13 ng ml−1 (10–20), P<0.0001). Increasing FABP4 tertiles were significantly associated with parameters of LVDD, the number of LVDD components, physical performance and epicardial fat thickness. In multivariate regression analysis adjusting for age, sex and adiposity, FABP4 levels remained significantly associated with parameters of diastolic function. The association of FABP4 levels with LVDD was mainly observed in subjects with metabolic complications, but not in metabolically healthy obese.Conclusions:FABP4 levels are significantly associated with LVDD in obese subjects, when the MetS is present. Thus, FABP4 may be a link between obesity and cardiometabolic disorders.

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Mannose-Binding Lectin in Obesity with Different Degrees of Metabolic Syndrome Abnormalities: Association with Atherogenic and Metabolic Traits

Cited by 11 publications

References 43 publications

Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

Clinical and laboratory associations of mannose-binding lectin in 219 adults with IgG subclass deficiency

Alterations of Plasma Lysophosphatidylcholine Species in Obesity and Weight Loss

Adipocyte fatty acid-binding protein levels are associated with left ventricular diastolic dysfunction in morbidly obese subjects

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