Manual, semi-automated, and automated delineation of chronic brain lesions: A comparison of methods

Wilke, Marko; Haan, Bianca de; Juenger, Hendrik; Karnath, Hans‐Otto

doi:10.1016/j.neuroimage.2011.04.014

Cited by 105 publications

(102 citation statements)

References 58 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…Brain lesions from each patient were drawn on the standard Montreal Neurological Institute's (MNI) brain template by a trained assistant naive to the patients' neuropsychological profile using the MRICro software (Rorden and Brett, 2000, for similar approaches see Spierer et al (2009), or Manuel et al (2013). The manual reconstruction of the lesions on a template has been demonstrated to be as accurate as automatic or semi-automatic reconstruction in two comparative studies (Fiez et al, 2000;Wilke et al, 2011). We would further note that the manual procedure was well adapted to the present retrospective study in which lesion reconstructions were based on clinical radiologic data that were not acquired for research purposes and thus showed variable acquisition parameters.…”

Section: Voxel-based Statistical Analyses Of Anatomo-functional Corrementioning

confidence: 84%

Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

et al. 2016

View full text Add to dashboard Cite

Abstract-Verbal fluency refers to the ability to generate as many words as possible in a limited time interval, without repetition and according to either a phonologic (each word begins with a given letter) or a semantic rule (each word belongs to a given semantic category). While current literature suggests the involvement of left fronto-temporal structures in fluency tasks, whether the same or distinct brain areas are necessary for each type of fluency remains unclear. We tested the hypothesis for an involvement of partly segregated cortico-subcortical structures between phonologic and semantic fluency by examining with a voxel-based lesion symptom mapping approach the effects of brain lesions on fluency scores corrected for age and education level in a group of 191 unselected braindamaged patients with a first left or right hemispheric lesion. There was a positive correlation between the scores to the two types of fluency, suggesting that common mechanisms underlie the word generation independent of the production rule. The lesion-symptom mapping revealed that lesions to left basal ganglia impaired both types of fluency and that left superior temporal, supramarginal and rolandic operculum lesions selectively impaired phonologic fluency and left middle temporal lesions impaired semantic fluency. Our results corroborate current neurocognitive models of word retrieval and production, and refine the role of cortical-subcortical interaction in lexical search by highlighting the common executive role of basal ganglia in both types of verbal fluency and the preferential involvement of the ventral and dorsal language pathway in semantic and phonologic fluency, respectively. Ó

show abstract

Section: Voxel-based Statistical Analyses Of Anatomo-functional Corrementioning

confidence: 84%

Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…For VLSM analyses, stroke lesions were manually drawn in all three planes (axial, coronal, sagittal) on each slice of the T 1 images using MRIcron (Rorden and Brett, 2000), as it has been shown to be the best method for lesion mapping as compared with semi-automated or automated processing (Wilke et al, 2011). FLAIR images were used as a reference.…”

Section: Imaging Methods and Voxel-based Lesion-symptom Mapping Analysismentioning

confidence: 99%

Lesion correlates of patholinguistic profiles in chronic aphasia: comparisons of syndrome-, modality- and symptom-level assessment

Henseler

Regenbrecht

Obrig

2014

Brain

View full text Add to dashboard Cite

One way to investigate the neuronal underpinnings of language competence is to correlate patholinguistic profiles of aphasic patients to corresponding lesion sites. Constituting the beginnings of aphasiology and neurolinguistics over a century ago, this approach has been revived and refined in the past decade by statistical approaches mapping continuous variables (providing metrics that are not simply categorical) on voxel-wise lesion information (voxel-based lesion-symptom mapping). Here we investigate whether and how voxel-based lesion-symptom mapping allows us to delineate specific lesion patterns for differentially fine-grained clinical classifications. The latter encompass 'classical' syndrome-based approaches (e.g. Broca's aphasia), more symptom-oriented descriptions (e.g. agrammatism) and further refinement to linguistic sub-functions (e.g. lexico-semantic deficits for inanimate versus animate items). From a large database of patients treated for aphasia of different aetiologies (n = 1167) a carefully selected group of 102 first ever ischaemic stroke patients with chronic aphasia (; 12 months) were included in a VLSM analysis. Specifically, we investigated how performance in the Aachen Aphasia Test-the standard clinical test battery for chronic aphasia in German-relates to distinct brain lesions. The Aachen Aphasia Test evaluates aphasia on different levels: a non-parametric discriminant procedure yields probabilities for the allocation to one of the four 'standard' syndromes (Broca, Wernicke, global and amnestic aphasia), whereas standardized subtests target linguistic modalities (e.g. repetition), or even more specific symptoms (e.g. phoneme repetition). Because some subtests of the Aachen Aphasia Test (e.g. for the linguistic level of lexico-semantics) rely on rather coarse and heterogeneous test items we complemented the analysis with a number of more detailed clinically used tests in selected mostly mildly affected subgroups of patients. Our results indicate that: (i) Aachen Aphasia Test-based syndrome allocation allows for an unexpectedly concise differentiation between 'Broca's' and 'Wernicke's' aphasia corresponding to non-overlapping anterior and posterior lesion sites; whereas (ii) analyses for modalities and specific symptoms yielded more circumscribed but partially overlapping lesion foci, often cutting across the above syndrome territories; and (iii) especially for lexico-semantic capacities more specialized clinical test-batteries are required to delineate precise lesion patterns at this linguistic level. In sum this is the first report on a successful lesion-delineation of syndrome-based aphasia classification highlighting the relevance of vascular distribution for the syndrome level while confirming and extending a number of more linguistically motivated differentiations, based on clinically used tests. We consider such a comprehensive view reaching from the syndrome to a fine-grained symptom-oriented assessment mandatory to converge neurolinguistic, patholinguistic and clinical-therapeuti...

show abstract

“…For example, Kennedy et al (2009) suggest that VBM techniques provide a reasonable Bfirst pass^for determination of where differences may reside between two groups, but manual tracing of specific ROIs may provide the most accurate quantitative measurements (also see Wilke et al 2011). Relatedly, Wenger et al (2014) have shown that in younger healthy control, typically developing individuals (20-30 years of age) where there would be minimal age related differences and reduced likelihood of underlying pathology that automated methods approximate manual tracing.…”

Section: Overview Of Structural Neuroimaging Analysesmentioning

confidence: 99%

Structural Image Analysis of the Brain in Neuropsychology Using Magnetic Resonance Imaging (MRI) Techniques

Bigler

2015

Neuropsychol Rev

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) of the brain provides exceptional image quality for visualization and neuroanatomical classification of brain structure. A variety of image analysis techniques provide both qualitative as well as quantitative methods to relate brain structure with neuropsychological outcome and are reviewed herein. Of particular importance are more automated methods that permit analysis of a broad spectrum of anatomical measures including volume, thickness and shape. The challenge for neuropsychology is which metric to use, for which disorder and the timing of when image analysis methods are applied to assess brain structure and pathology. A basic overview is provided as to the anatomical and pathoanatomical relations of different MRI sequences in assessing normal and abnormal findings. Some interpretive guidelines are offered including factors related to similarity and symmetry of typical brain development along with size-normalcy features of brain anatomy related to function. The review concludes with a detailed example of various quantitative techniques applied to analyzing brain structure for neuropsychological outcome studies in traumatic brain injury.

show abstract

Manual, semi-automated, and automated delineation of chronic brain lesions: A comparison of methods

Cited by 105 publications

References 58 publications

Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

Partly segregated cortico-subcortical pathways support phonologic and semantic verbal fluency: A lesion study

Lesion correlates of patholinguistic profiles in chronic aphasia: comparisons of syndrome-, modality- and symptom-level assessment

Structural Image Analysis of the Brain in Neuropsychology Using Magnetic Resonance Imaging (MRI) Techniques

Contact Info

Product

Resources

About