Manufacturing Cyclodextrin Fibers Using Water

Kelly, Alesha; Ahmed, Jubair; Edirisinghe, Mohan

doi:10.1002/mame.202100891

Cited by 11 publications

(6 citation statements)

References 62 publications

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“…[66,67] For the resultant products, the working fluids always play their important roles. [68][69][70][71] When the working fluid is unsolidifiable, a) The symbols V, F, D, and 𝜂 represent the applied voltage (kV), the fluid flow rate (mL/h), the distance between the collector and the tip of the concentric spinneret (cm), and the viscosity of the working fluid (mPa•s).…”

Section: The Detachable Spinneret and The Three Ehda Working Processesmentioning

confidence: 99%

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Chen,

Zhou,

Fang

et al. 2023

Macro Materials & Eng

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In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution of a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by a novel spinneret, is homemade for conducting the three processes. The three types of products are electrospun nanofibers E1, electrosprayed microparticles E2, and core‐shell nanofibers E3. SEM and TEM results indicate that they have the anticipated morphologies and inner structures. X‐ray diffraction and Fourier Transform Infrared results verify that KET is mainly amorphous in all the composites due to its fine compatibility with HPMC. In vitro dissolution tests demonstrate that the drug rapid release performances has an order of E3>E1>E2≫KET powders. The fast dissolution mechanisms are suggested and the advantages of the three products are compared. The super performance of E3 in furnishing the rapid release is attributed to a synergistic action of small size (of the shell thickness), high porosity, amorphous state of drug, and the solubility of HPMC. EHDA nanostructures can support the development of nano drug delivery systems (DDSs) through tailoring the spatial distribution of drug molecules within the nano products.

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Section: The Detachable Spinneret and The Three Ehda Working Processesmentioning

confidence: 99%

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Chen,

Zhou,

Fang

et al. 2023

Macro Materials & Eng

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“…Utilizing natural polymers and those that do not require harsh solvents will lead to more sustainability in the field. One particular polymer, cyclodextrin, has been spun with PG and electrospinning to form a highly sustainable and environmentally friendly hybrid structure for various biomedical applications (Kelly et al, 2022).…”

Section: Sustainable Hybrid Fiber Productionmentioning

confidence: 99%

“…(a) Image of the cyclodextrin PG‐spun and electrospun “super‐mat” consisting of a PG‐spun cyclodextrin base and electrospun exterior, (b) scanning electron microscopy image of the “super‐mat” under high magnification showing the interface between the electrospun and the PG‐spun cyclodextrin fibers, thicker gyration fibers have been highlighted with dotted lines. ((Kelly et al, 2022) (permission may be required)).…”

Section: Pressurized Gyrationmentioning

confidence: 99%

Recent developments in the use of centrifugal spinning and pressurized gyration for biomedical applications

Ahmed

Gultekinoglu

Edirisinghe

2023

WIREs Nanomed Nanobiotechnol

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Centrifugal spinning is a technology used to generate small diameter fibers and has been extensively studied for its vast applications in biomedical engineering. Centrifugal spinning is known for its rapid production rate and has inspired the creation of other technologies which leverage the high‐speed rotation, namely Pressurized Gyration. Pressurized gyration incorporates a unique applied gas pressure which serves to provide additional control over the fiber production process. The resulting fibers are uniquely suitable for a range of healthcare‐related applications that are thoroughly discussed in this work, which involve scaffolds for tissue engineering, solid dispersions for drug delivery, antimicrobial meshes for filtration and bandage‐like fibrous coverings for wound healing. In this review, the notable recent developments in centrifugal spinning and pressurized gyration are presented and how these technologies are being used to further the range of uses of biomaterials engineering, for example the development of core‐sheath fabrication techniques for multi‐layered fibers and the combination with electrospinning to produce advanced fiber mats. The enormous potential of these technologies and their future advancements highlights how important they are in the biomedical discipline.This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology‐Inspired Nanomaterials > Lipid‐Based Structures

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“…Similarly, fiber production from water-soluble cyclodextrin has also recently been successful and the use of such oligosaccharide polymeric fibers in a variety of functional applications such as in healthcare can enhance suitability goals. [133] Green solvents are a substitute for organic solvents. Organic solvents are classed as synthetic or natural, whereas similar to natural polymers, natural solvents are derived from living organisms.…”

Section: Sustainable Polymers and Solventsmentioning

confidence: 99%

Environmental Impact of Polymer Fiber Manufacture

Amarakoon

Alenezi

Homer-Vanniasinkam

et al. 2022

Macro Materials & Eng

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This review focuses on the effects on the environment due to the production of polymer‐solvent solutions and the manufacture of polymeric fibers of thicknesses from a nanometer up to a millimeter using these solutions. The most common polymeric fiber manufacture methods are reviewed based on their effects on the environment, particularly from the use of hazardous materials and energy consumption. Published literature is utilized to analyze and quantify energy consumption of the manufacturing methods electrospinning, phase separation, self‐assembly, template synthesis, drawing and pressurized gyration. The results show that during the manufacturing stage of the lifecycle of polymeric fibers, pressurized gyration is more environmentally efficient primarily due to its mass‐producing features and fast processing of polymeric solutions into fibers, it also works best with water‐based solutions. Further green alternatives are described such as the use of sustainable polymers and solvents to enhance the environmental benefit. Overall, it is shown that the most effective method of curbing the environmental impact of manufacturing polymeric fibers is the use of nontoxic, water‐soluble polymers along with the evasion of toxic solvents.

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Manufacturing Cyclodextrin Fibers Using Water

Cited by 11 publications

References 62 publications

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Recent developments in the use of centrifugal spinning and pressurized gyration for biomedical applications

Environmental Impact of Polymer Fiber Manufacture

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