Maoberry (Antidesma bunius) ameliorates oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet

Abstract

BackgoundChronic fat-rich diets consumption is increased risk associated with cardiovascular diseases (CVD). Prevention or reduction the progression of cardiac tissue deterioration could benefit in CVD. This study aimed to examine the effects of maoberry (Antidesma bunius), a antioxidant-rich tropical fruit, supplementation on oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet (HFD).MethodsThe male rats orally received HFD with maoberry extract doses of 0.38, 0.76 or 1.52 g/kg or simvastatin (10 mg/kg) for 12 weeks. At the end of the experimental period, the rats were fasted, euthanized and harvested for the hearts.ResultsSignificantly reduced oxidative stress (malondialdehyde levels) and enhanced antioxidant capacity (ferric-reducing activities) in cardiac tissues of the rats were found. Maoberry extract remarkably ameliorated the expressions of genes involved with pro-inflammatory such as the tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and endothelial nitric oxide synthase (eNOS).ConclusionsOur findings suggest that maoberry extract has remarkable effects on preventing progression of cardiac tissue deterioration at least through lowering oxidative stress and inflammation.

The potential of antioxidant-rich Maoberry (Antidesma bunius) extract on fat metabolism in liver tissues of rats fed a high-fat diet

“…The environmental conditions are controlled in order to reduce or get rid of animal distress. Our previous studies reported that Maoberry extract could benefit against hypercholesterolemia and cardiovascular disease risk factors by antioxidant and anti-inflammation properties [8, 9]. The current study further demonstrates the contributions of Maoberry extract on fat metabolism in liver tissue.…”

“…Synergistic interactions of those active ingredients available in Maobery extract have the opportunity to improve the fat metabolism in the liver tissues fed a high-fat diet. In addition to improving fat metabolism, Maoberry extract from our previous studies also showed a reduction of oxidative stress and inflammation in heart tissues [8]. Therfore, this can confirm the ability of strong antioxidant activity that is possessed by Maoberry extract.…”

“…Previous reports suggest that fruits rich in flavonoids and phenolic acids have been shown to improve the features of NAFLD, such as oxidative stress, dyslipidemia, liver steatosis, and inflammation in rodents [10–12]. Our previous study reported the health benefits of Maoberry around four to sixteen portions a day could against in hypercholesterolemia and progression of cardiac tissue deterioration in rats [8, 9]. Supplement rats with Maoberry might be somehow useful on fat metabolism in liver tissues.…”

“…Consumption of a high fat diet causes increasing body weight and enlargement of internal organs, including the liver, as well as dyslipidemia and obesity in rats [7–9]. Feeding high fat diet to rats were able to attribute characteristics hypercholesterolemia which is relevance to human biology [8–12]. A high fat diet was therefore an option in this study.…”

Mechanisms of Chronic Metabolic Stress in Arrhythmias

“…Further, WT hearts had significantly more inducible ventricular tachycardia than NOX2 KO hearts after HFD. Part of the arrhythmic effect of NOX2 is due to activation of CaMKII, which phosphorylates the RyR2 channels [ 108 , 109 ]. This causes increased calcium leakage from the SR, which worsens mitochondrial function and promotes arrhythmias [ 27 , 77 ].…”