MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons

Tymanskyj, Stephen R.; Scales, Tim M.; Gordon‐Weeks, Phillip R.

doi:10.1016/j.mcn.2011.10.003

Cited by 67 publications

(80 citation statements)

References 56 publications

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“…MAP1B is one of the earliest MAPs to be expressed during development. In vitro studies highlight a key role of MAP1B in multiple processes that are essential for neuronal regeneration, including axon guidance, retraction and branching (Bouquet et al, 2007; Stroissnigg et al, 2007; Barnat et al, 2010; Tymanskyj et al, 2012). Deletion of MAP1B in mice increases axonal branching (Bouquet et al, 2007; Tymanskyj et al, 2012).…”

Section: Cytoskeletal Dynamics and Reorganization Underlying The Earlmentioning

confidence: 99%

“…In vitro studies highlight a key role of MAP1B in multiple processes that are essential for neuronal regeneration, including axon guidance, retraction and branching (Bouquet et al, 2007; Stroissnigg et al, 2007; Barnat et al, 2010; Tymanskyj et al, 2012). Deletion of MAP1B in mice increases axonal branching (Bouquet et al, 2007; Tymanskyj et al, 2012). Live imaging analysis of branch formation demonstrated that in the absence of MAP1B axonal protrusions are more likely to be stabilized and therefore mature into a branch (Bouquet et al 2004; Barnat et al, 2016).…”

Section: Cytoskeletal Dynamics and Reorganization Underlying The Earlmentioning

confidence: 99%

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It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches

Armijo-Weingart

Gallo

2017

Molecular and Cellular Neuroscience

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The formation of axon collateral branches from the pre-existing shafts of axons is an important aspect of neurodevelopment and the response of the nervous system to injury. This article provides an overview of the role of the cytoskeleton and signaling mechanisms in the formation of axon collateral branches. Both the actin filament and microtubule components of the cytoskeleton are required for the formation of axon branches. Recent work has begun to shed light on how these two elements of the cytoskeleton are integrated by proteins that functionally or physically link the cytoskeleton. While a number of signaling pathways have been determined as having a role in the formation of axon branches, the complexity of the downstream mechanisms and links to specific signaling pathways remain to be fully determined. The regulation of intra-axonal protein synthesis and organelle function are also emerging as components of signal-induced axon branching. Although much has been learned in the last couple of decades about the mechanistic basis of axon branching we can look forward to continue elucidating this complex biological phenomenon with the aim of understanding how multiple signaling pathways, cytoskeletal regulators and organelles are coordinated locally along the axon to give rise to a branch.

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Section: Cytoskeletal Dynamics and Reorganization Underlying The Earlmentioning

confidence: 99%

Section: Cytoskeletal Dynamics and Reorganization Underlying The Earlmentioning

confidence: 99%

It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches

Armijo-Weingart

Gallo

2017

Molecular and Cellular Neuroscience

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“…Other MT shaft binders are Tau which protects MTs against the MT-severing protein Katanin in axons (not shown; Qiang et al, 2006), and mammalian MAP1B can cross-link MTs as well as mediate actin-MT linkage during axon growth (Bouquet et al, 2007;Riederer, 2007). Tau, MAP1B and Shot (in an EB1-independent mode) influence MT polymerisation kinetics through yet unknown mechanisms (stippled grey arrow; Alves-Silva et al, 2012;Feinstein and Wilson, 2005;Tymanskyj et al, 2012).…”

Section: Box 1 Abps and Mtbps As Essential Regulators Of Cytoskeletamentioning

confidence: 99%

Using fly genetics to dissect the cytoskeletal machinery of neurons during axonal growth and maintenance

Prokop

Beaven

et al. 2013

Journal of Cell Science

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SummaryThe extension of long slender axons is a key process of neuronal circuit formation, both during brain development and regeneration. For this, growth cones at the tips of axons are guided towards their correct target cells by signals. Growth cone behaviour downstream of these signals is implemented by their actin and microtubule cytoskeleton. In the first part of this Commentary, we discuss the fundamental roles of the cytoskeleton during axon growth. We present the various classes of actin-and microtubule-binding proteins that regulate the cytoskeleton, and highlight the important gaps in our understanding of how these proteins functionally integrate into the complex machinery that implements growth cone behaviour. Deciphering such machinery requires multidisciplinary approaches, including genetics and the use of simple model organisms. In the second part of this Commentary, we discuss how the application of combinatorial genetics in the versatile genetic model organism Drosophila melanogaster has started to contribute to the understanding of actin and microtubule regulation during axon growth. Using the example of dystonin-linked neuron degeneration, we explain how knowledge acquired by studying axonal growth in flies can also deliver new understanding in other aspects of neuron biology, such as axon maintenance in higher animals and humans.

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“…Posttranslational modifications can affect both MAP1B distribution and function. MAP1B can be phosphorylated by many kinases such as casein kinase II (Diaz-Nido et al 1988;Ulloa et al 1993), the serine/threonine protein kinase GSK3 (Garcia- Perez et al 1998;Tymanskyj et al 2012), the cyclin-dependent kinase 5 together with its regulatory subunit p35 (Kawauchi et al 2005;Paglini et al 1998;Pigino et al 1997), the dual-specificity tyrosine phosphorylation-regulated kinase DYRK1 (Scales et al 2009), cdc2 (Ulloa et al 1994b), and members of the mitogen-activated protein kinase family like ERK1/ERK2 (Loeb et al 1992) and JNK1 (Chang et al 2003). MAP1B can bind both actin and MTs, and has been suggested to link the two cytoskeletal elements together (Garcia Rocha and Avila 1995;Mansfield et al 1991;Pedrotti and Islam 1995;Pedrotti et al 1996).…”

Section: Map1 Family Member Map1bmentioning

confidence: 99%

“…MAP1B, compared with other MAPs, is a weak MT stabilizer (Takemura et al 1992). Recent studies suggest that MAP1B preferably associates to dynamic, tyrosinated MTs Tymanskyj et al 2012;Utreras et al 2008). MAP1B also interacts with other MT-interacting proteins, including tubulin-tyrosine ligase and EB1/EB3, dynein regulators like LIS1, scaffolding proteins such as dystonin-α2, and motor protein KIF21A (Cheng et al 2014;Villarroel-Campos and Gonzalez-Billault 2014).…”

Section: Map1 Family Member Map1bmentioning

confidence: 99%

Microtubule Organization and Microtubule-Associated Proteins (MAPs)

2016

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Dendrites have a unique microtubule organization. In vertebrates, dendritic microtubules are organized in antiparallel bundles, oriented with their plus ends either pointing away or toward the soma. The mixed microtubule arrays control intracellular trafficking and local signaling pathways, and are essential for dendrite development and function. The organization of microtubule arrays largely depends on the combined function of different microtubule regulatory factors or generally named microtubule-associated proteins (MAPs). Classical MAPs, also called structural MAPs, were identified more than 20 years ago based on their ability to bind to and copurify with microtubules. Most classical MAPs bind along the microtubule lattice and regulate microtubule polymerization, bundling, and stabilization. Recent evidences suggest that classical MAPs also guide motor protein transport, interact with the actin cytoskeleton, and act in various neuronal signaling networks. Here, we give an overview of microtubule organization in dendrites and the role of classical MAPs in dendrite development, dendritic spine formation, and synaptic plasticity. IntroductionMicrotubules (MTs) are cytoskeletal structures that play essential roles in all eukaryotic cells. MTs are important not only during cell division but also in non-dividing cells, where they are critical structures in numerous cellular processes such as cell motility, migration, differentiation, intracellular transport and organelle positioning. MTs are composed of two proteins, α-and β-tubulin, that form heterodimers and organize themselves in a head-to-tail manner. MTs are dynamic and they can rapidly switch between cycles of growth and shrinkage. This MT

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MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons

Cited by 67 publications

References 56 publications

It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches

It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches

Using fly genetics to dissect the cytoskeletal machinery of neurons during axonal growth and maintenance

Microtubule Organization and Microtubule-Associated Proteins (MAPs)

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