MAP3K19 Promotes the Progression of Tuberculosis-Induced Pulmonary Fibrosis Through Activation of the TGF-β/Smad2 Signaling Pathway

Xia, Yu; Wang, Haiyue; Shao, Meihua; Liu, Xuemei; Sun, Feng

doi:10.1007/s12033-023-00941-6

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…Progressive pulmonary fibrosis (PPF) is characterized by progressive scarring of the lungs [1], remodeling of the lung’s extracellular matrix (ECM), and increased deposition of collagen and alpha-smooth muscle actin (αSMA) [2]. This is thought to be driven by elevated levels of fibroblasts that have differentiated into activated myofibroblasts [3, 4]. PPF is a devastating form of interstitial lung disease (ILD), has limited treatment options, and is often fatal, especially in idiopathic pulmonary fibrosis (IPF) with a life expectancy of 3-5 years after diagnosis [5].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Adrenalectomy on Bleomycin-Induced Pulmonary Fibrosis in Mice

McGovern,

Perry,

Ghincea

et al. 2024

Preprint

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Progressive lung fibrosis is often fatal and has limited treatment options. Though the mechanisms are poorly understood, fibrosis is increasingly linked with catecholamines such as adrenaline (AD) and noradrenaline (NA), and hormones such as aldosterone (ALD). The essential functions of adrenal glands include the production of catecholamines and numerous hormones, but the contribution of adrenal glands to lung fibrosis remains less well studied. Here, we characterized the impact of surgical adrenal ablation in the bleomycin model of lung fibrosis. Wild type mice underwent surgical adrenalectomy or sham surgery followed by bleomycin administration. We found that the bleomycin induced collagen over deposition in the lung was not affected by adrenalectomy. However, histologic indices of lung remodeling were ameliorated by adrenalectomy. These findings were accompanied by a decrease in bronchoalveolar lavage (BAL) cell count along with concomitant reductions in alpha smooth muscle actin (⍺SMA) and fibronectin. Surgical adrenalectomy completely abrogated AD detection in all compartments, but only reduced NA in the BAL of uninjured mice. Systemic ALD levels were reduced after adrenalectomy. Taken together, these results support the presence of pulmonary-adrenal axis in lung fibrosis and suggest that adrenalectomy is protective in this disease. Further investigation will be needed to better understand this observation and aid in the development of novel therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

The Effect of Adrenalectomy on Bleomycin-Induced Pulmonary Fibrosis in Mice

McGovern,

Perry,

Ghincea

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Mechanisms of LPS–induced epithelial mesenchymal transition in bEECs

Sun,

Song,

Zhao

et al. 2024

Theriogenology

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The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice

McGovern,

Perry,

Ghincea

et al. 2025

American Journal of Physiology-Lung Cellular and Molecular Phys

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Progressive lung fibrosis is often fatal and has limited treatment options. Though the mechanisms are poorly understood, fibrosis is increasingly linked with catecholamines such as adrenaline (AD) and noradrenaline (NA), and hormones such as aldosterone (ALD). The essential functions of the adrenal glands include the production of catecholamines and numerous hormones, but the contribution of adrenal glands to lung fibrosis remains less well studied. Here, we characterized the impact of surgical adrenal ablation in the bleomycin model of lung fibrosis. Wild type mice underwent surgical adrenalectomy or sham surgery followed by bleomycin administration. We found that while bleomycin-induced collagen over-deposition in the lung was not affected by adrenalectomy, histologic indices of lung remodeling were ameliorated. These findings were accompanied by a decrease of lymphocytes in bronchoalveolar lavage (BAL) and macrophages in lung tissues, along with concomitant reductions in alpha smooth muscle actin (⍺SMA) and fibronectin. Surgical adrenalectomy completely abrogated AD, not NA, detection in all compartments. Systemic ALD levels were reduced after adrenalectomy while ALD levels in lung tissues remained unaffected. Taken together, these results support the presence of a pulmonary-adrenal axis in lung fibrosis and suggest that adrenalectomy is protective in this disease. Further investigation will be needed to better understand this observation and aid in the development of novel therapeutic strategies.

show abstract

MAP3K19 Promotes the Progression of Tuberculosis-Induced Pulmonary Fibrosis Through Activation of the TGF-β/Smad2 Signaling Pathway

Cited by 3 publications

References 67 publications

The Effect of Adrenalectomy on Bleomycin-Induced Pulmonary Fibrosis in Mice

The Effect of Adrenalectomy on Bleomycin-Induced Pulmonary Fibrosis in Mice

Mechanisms of LPS–induced epithelial mesenchymal transition in bEECs

The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice

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