Mapping Brain Function Using a 30-Day Interval between Baseline and Activation: A Novel Arterial Spin Labeling fMRI Approach

Borogovac, Ajna; Habeck, Christian; Small, Scott A.; Asllani, Iris

doi:10.1038/jcbfm.2010.89

Cited by 26 publications

(52 citation statements)

References 37 publications

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“…mL/100 g/min), facilitating comparisons across sites and scanning sessions (33). This particular feature offers an advantage over the more commonly applied blood oxygen level dependent (BOLD) fMRI, which is susceptible to baseline drift across longer time scales (34) and produces increased intersubject variability (35). Further, this capability makes ASL MRI particularly suitable for measuring drug effects over varying intervals.…”

Section: Asl Mri Methodologymentioning

confidence: 99%

Arterial spin labeling MRI

Wolk

Detre

2012

Current Opinion in Neurology

125

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Purpose of the Review The search for biomarkers that detect and track disease progression in early Alzheimer’s Disease (AD) has been a major pursuit for two decades. Functional measures reflecting alterations of synaptic activity associated with neuronal dysfunction have displayed promise for following disease course in early stages. While fluorodeoxyglucose positron emission tomography (FDG PET) and blood oxygen level dependent functional MRI (BOLD fMRI) have been studied extensively for this purpose, this review will discuss the emergence and potential role of arterial spin labeling (ASL) MRI, which measures cerebral blood flow (CBF), in neurodegeneration. Recent Findings Several recent studies have explored ASL MRI in early and prodromal AD and have reported areas of hypoperfusion that overlap considerably with hypo-metabolism frequently reported with FDG PET. However, some studies have also noted increased regional CBF of patients with prodromal and early stage clinical AD, which may have implications for pathophysiology and/or the role of compensatory responses to neurodegeneration. Additionally, a few recent studies have begun to use this modality to explore the role of cerebrovascular factors in cognitive decline and its relationship to AD. Summary SL MRI is just beginning to be applied more widely to various neurodegenerative conditions. Initial data suggest that this methodology may provide similar information to FDG PET, but with several advantages in the ease of acquisition and expense. Additional applications of this modality, including task-related studies and testing of pharmacological effects, are underexplored, but potentially of significant value in understanding disease related functional changes and treatment effects.

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Section: Asl Mri Methodologymentioning

confidence: 99%

Arterial spin labeling MRI

Wolk

Detre

2012

Current Opinion in Neurology

125

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“…First, ASL techniques provide information on CBF in the baseline state and on how CBF changes with activation. Second, the ASL measurement is more stable in the face of scanner drift, so that it is possible to measure changes in activity between two states widely separated in time (Borogovac et al, 2010; Wang et al, 2003). Third, while the complex sensitivity of the BOLD signal creates difficulty in interpretation, it also offers the possibility of calculating changes in CMRO 2 when BOLD and CBF measurements are combined.…”

Section: Introductionmentioning

confidence: 99%

Prospects for quantitative fMRI: Investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans

2011

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Functional magnetic resonance imaging (fMRI) provides an indirect reflection of neural activity change in the working brain through detection of blood oxygenation level dependent (BOLD) signal changes. Although widely used to map patterns of brain activation, fMRI has not yet met its potential for clinical and pharmacological studies due to difficulties in quantitatively interpreting the BOLD signal. This difficulty is due to the BOLD response being strongly modulated by two physiological factors in addition to the level of neural activity: the amount of deoxyhemoglobin present in the baseline state and the coupling ratio, n, of evoked changes in blood flow and oxygen metabolism. In this study, we used a quantitative fMRI approach with dual measurement of blood flow and BOLD responses to overcome these limitations and show that these two sources of modulation work in opposite directions following caffeine administration in healthy human subjects. A strong 27% reduction in baseline blood flow and a 22% increase in baseline oxygen metabolism after caffeine consumption led to a decrease in baseline blood oxygenation and was expected to increase the subsequent BOLD response to the visual stimulus. Opposing this, caffeine reduced n through a strong 61% increase in the evoked oxygen metabolism response to the visual stimulus. The combined effect was that BOLD responses pre- and post-caffeine were similar despite large underlying physiological changes, indicating that the magnitude of the BOLD response alone should not be interpreted as a direct measure of underlying neurophysiological changes. Instead, a quantitative methodology based on dual-echo measurement of blood flow and BOLD responses is a promising tool for applying fMRI to disease and drug studies in which both baseline conditions and the coupling of blood flow and oxygen metabolism responses to a stimulus may be altered.

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“…Second, a method that varies labeling duration rather than postlabeling delay has been developed [55]. This method has been shown to be ~30% shorter than the multiple-PLD method [55].…”

Section: From Signal To Absolute Quantification Of Cbfmentioning

confidence: 99%

Arterial Spin Labeling (ASL) fMRI: Advantages, Theoretical Constrains and Experimental Challenges in Neurosciences

Borogovac

Asllani

2012

International Journal of Biomedical Imaging

Self Cite

104

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Cerebral blood flow (CBF) is a well-established correlate of brain function and therefore an essential parameter for studying the brain at both normal and diseased states. Arterial spin labeling (ASL) is a noninvasive fMRI technique that uses arterial water as an endogenous tracer to measure CBF. ASL provides reliable absolute quantification of CBF with higher spatial and temporal resolution than other techniques. And yet, the routine application of ASL has been somewhat limited. In this review, we start by highlighting theoretical complexities and technical challenges of ASL fMRI for basic and clinical research. While underscoring the main advantages of ASL versus other techniques such as BOLD, we also expound on inherent challenges and confounds in ASL perfusion imaging. In closing, we expound on several exciting developments in the field that we believe will make ASL reach its full potential in neuroscience research.

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Mapping Brain Function Using a 30-Day Interval between Baseline and Activation: A Novel Arterial Spin Labeling fMRI Approach

Cited by 26 publications

References 37 publications

Arterial spin labeling MRI

Arterial spin labeling MRI

Prospects for quantitative fMRI: Investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans

Arterial Spin Labeling (ASL) fMRI: Advantages, Theoretical Constrains and Experimental Challenges in Neurosciences

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