Mapping Cancer Mortality in England and Wales

Mj, Gardner

doi:10.1093/oxfordjournals.bmb.a071998

Cited by 21 publications

(12 citation statements)

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“…Deaths for later periods and all the cancer registrations were coded by the Office of Population Censuses and Surveys according to the eighth or ninth ICD revision, as appropriate. (Gardner et al, 1983(Gardner et al, , 1984, which were used to estimate death rates up to 1979. We supplemented these data using death rates for Cumbria, supplied by OPCS for the period 1980-88, to estimate Cumbria death rates for 1979-88.…”

Section: Study Populationmentioning

confidence: 99%

Cancer mortality and morbidity among workers at the Sellafield plant of British Nuclear Fuels

Douglas

Omar²,

Smith³

1994

Br J Cancer

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Summary The mortality of all 14,282 Cancer mortality rates were significantly in excess of national rates for cancers of the pleura (nine observed, 2.6 expected; P = 0.001), thyroid (six observed, 1.8 expected; P = 0.01) and ill defined and secondary sites (53 observed, 39.2 expected; P = 0.02). There were significant deficits of cancers of the liver and gall bladder, larynx and lung. Among radiation workers there were significant positive correlations between accumulated radiation dose and mortality from cancers of ill-defined and secondary sites (10 year lag: P = 0.01) and for leukaemia (2 year lag: P = 0.009), but not for cancers of the pleura and thyroid cancer. Previous findings of such associations with multiple myeloma and bladder cancer were less strong. There was a significant excess of incident cases of cancer of the oesophagus (P = 0.01), but this was not associated with accumulated radiation dose. For cancers other than leukaemia, the dose-response risk estimates were below those of the adult atomic bomb survivors, but the 90% confidence interval included risks of zero and of 2-3 times higher. For leukaemia (12 deaths, excluding CLL), under an excess relative risk model, the risk estimate derived for the Sellafield workers was about four times higher than that for the adult atomic bomb survivors with a confidence interval ranging from a half to nearly 20 times that of the atomic bomb survivors. Overall, however, there was no excess of leukaemia among the workers compared with national rates.

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Section: Study Populationmentioning

confidence: 99%

Cancer mortality and morbidity among workers at the Sellafield plant of British Nuclear Fuels

Douglas

Omar²,

Smith³

1994

Br J Cancer

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“…Then the areas are shaded using either the standardized ratios themselves or a measure of their individual statistical significance. These techniques are familiar in many disease atlases, for example, Kemp et al 1985; Gardner et al 1983; Smans, Boyle, and Muir 1990. For rare diseases there is the problem that fluctuations marked on a map may represent merely random variation and appropriate methodology has been developed: empirical Bayes estimates of the standard ratios (Clayton and Kaldor 1987) and Poisson regression modeling to test for heterogeneity (Frome 1983).…”

Section: Introductionmentioning

confidence: 99%

Methods of Mapping and Identifying Small Clusters of Rare Diseases with Applications to Geographical Epidemiology

Alexander

Ricketts

Williams

et al. 1991

Geographical Analysis

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“…Cancer mortality statistics (see e.g., OPCS, 1985b) are frequently used for epidemiological research purposes thus only published by site. Such published data (Office of without specific attention being drawn to the problem that Population Censuses and Surveys, 1970-74;1979-85; such data reflect a mixture of tumour types (see e.g., Cancer Registrar General, 1975) were used to calculate the rates Research Campaign, 1981; Davies, 1981;Gardner et al, shown in Figure 1. 1983;McDowall & Balarajan, 1986;and most recently The wide disparity between the mortality and incidence Osterlind, 1986 Surveys (OPCS) were registered during this period.…”

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confidence: 99%