Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging

Chen, Yin-Ching I.; Choi, Ji‐Kyung; Andersen, Susan; Rosen, Bruce R.; Jenkins, Bruce G.

doi:10.1007/s00213-004-2034-0

Cited by 86 publications

(113 citation statements)

References 55 publications

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“…This pair of data showed that rats with no needle insertion do not differ from rats with needles inserted but without current passing in terms of rCBV time courses ( figure 1A). The time courses and rCBV maps from the whole AMPH-only group were similar to those published previously [5] .…”

Section: The Insertion Of Ea Needles Alone Did Not Cause the Rcbv Chasupporting

confidence: 83%

“…Preparation for microdialysis in the striatum were carried out as previously described [5] with the coordinate for the dialysate probe at [AP −0.26; ML 4.4; DV 7.0] [26]. Dialysate samples were acquired in 10 min time intervals.…”

Section: Microdialysismentioning

confidence: 99%

“…AMPH plus EA (AMPH+EA). DA, Glu, and GABA concentrations were assayed by HPLC with electrochemical detection (ESA, Chelmsford, MA) as described earlier [5] and in [14].…”

Section: Microdialysismentioning

confidence: 99%

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Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

Chen

Ren

Wang

et al. 2008

Neuroscience Letters

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The subcortical response to peripheral somatosensory stimulation is not well studied. Prior literature suggests that somatosensory stimulation can affect dopaminergic tone. We studied the effects of electrical stimulation near the median nerve on the response to an amphetamine induced increase in synaptic dopamine. We applied the electrical stimulation close to the median nerve 20 minutes after administration of 3mg/kg amphetamine. We used fMRI and microdialysis to measure markers of DA release, together with the release of associated neurotransmitters of striatal Glutamate (Glu) and GABA.Result-1) Changes in cerebral blood volume (CBV), a marker used in fMRI, indicate that electrical stimulation significantly attenuated increased DA release (due to AMPH) in the striatum, thalamus, medial prefrontal and cingulate cortices. 2) Microdialysis showed that electrical stimulation increased Glu and GABA release and attenuated the AMPH-enhanced DA release. The striatal DA dynamics correlated with the CBV response.Conclusion-These results demonstrate that electrical stimulation near the median nerve activates Glu/GABA release which subsequently attenuate excess striatal DA release. These data provide evidence for physiologic modulation caused by electroacupuncture at points near the median nerve.

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Section: The Insertion Of Ea Needles Alone Did Not Cause the Rcbv Chasupporting

confidence: 83%

Section: Microdialysismentioning

confidence: 99%

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Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

Chen

Ren

Wang

et al. 2008

Neuroscience Letters

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“…Other efforts to decode the neurovascular coupling between dopamine receptor function and a concomitant hemodynamic change provide a solid basis for the interpretation of dopaminergically related signal. fMRI with drug challenges has consistently shown that D1-like agonism is associated with increased hemodynamics changes, while D2-like agonism is associated with negative hemodynamic changes 100–103 . Data further show that hemodynamic changes (measured using either BOLD or CBV) are strongly correlated with dopamine release measured using microdialysis at high dopamine levels, and are mediated for opposing changes at low dopamine release levels due to the higher affinity of D2 over D1 receptors 104–108 .…”

Section: Multi-modal Imaging Of Receptor Functional Dynamics Witmentioning

confidence: 99%

“…fMRI with drug challenges has consistently shown that D1-like agonism is associated with increased hemodynamics changes, while D2-like agonism is associated with negative hemodynamic changes 100–103 . Data further show that hemodynamic changes (measured using either BOLD or CBV) are strongly correlated with dopamine release measured using microdialysis at high dopamine levels, and are mediated for opposing changes at low dopamine release levels due to the higher affinity of D2 over D1 receptors 104–108 . Together, these animal data are surprisingly robust, with numerous studies across different dopamine antagonists and agonists of specific sub-types showing no exceptions to the coupling rules of D1/D5 yielding positive changes and D2/D3 yielding negative changes 11 .…”

Section: Multi-modal Imaging Of Receptor Functional Dynamics Witmentioning

confidence: 99%

News and views on in-vivo imaging of neurotransmission using PET and MRI

Sander

Hesse

2017

Q J Nucl Med Mol Imaging

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Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene‐dose effect from the X chromosome

Scofield

Bruner

Namjou

et al. 2008

Arthritis & Rheumatism

339

242

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Objective. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that predominantly affects women. Despite isolated reports of patients with coexisting Klinefelter's syndrome (47,XXY) and SLE, no association of Klinefelter's syndrome with SLE or any other autoimmune disease has been established. The present study was undertaken to investigate the prevalence of Klinefelter's syndrome in a large population of patients with SLE.Methods. Sex chromosome genotyping was performed in 981 SLE patients, of whom 213 were men. A first group of 844 SLE patients from 378 multiplex families and a second group of 137 men with nonfamilial SLE were evaluated. In selected cases, chromosomes were enumerated by fluorescence in situ hybridization (FISH) and karyotyping in transformed B cell lines.Results. Of 213 men with SLE, 5 had Klinefelter's syndrome (1 in 43). Four of them were heterozygous at X markers, and Klinefelter's syndrome was confirmed by FISH and karyotyping in the fifth. An overall rate of 47,XXY of 235 per 10,000 male SLE patients was found (95% confidence interval 77-539), a dramatic increase over the known prevalence of Klinefelter's syndrome in an unselected population (17 per 10,000 live male births). Asking men with SLE about fertility was highly sensitive (100%) for Klinefelter's syndrome. All 768 women with SLE were heterozygous at X.Conclusion. The frequency of Klinefelter's syndrome (47,XXY), often subclinical, is increased in men with SLE by ϳ14-fold compared with its prevalence in men without SLE. Diagnostic vigilance for 47,XXY in male patients with SLE is warranted. These data are the first to show an association of Klinefelter's syndrome with an autoimmune disease found predominantly in women. The risk of SLE in men with Klinefelter's syndrome is predicted to be similar to the risk in normal women with 46,XX and ϳ14-fold higher than in men with 46,XY, consistent with the notion that SLE susceptibility is partly explained by an X chromosome genedose effect.Systemic lupus erythematosus (SLE) is uncommon in men, being 10-fold more prevalent in women, a

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Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging

Abstract: These results suggest that phMRI may potentially prove useful to map DAR function non-invasively in multiple brain regions simultaneously.

Cited by 86 publications

References 55 publications

Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw

News and views on in-vivo imaging of neurotransmission using PET and MRI

Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene‐dose effect from the X chromosome

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