Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem

Duque, Ewing; Mangas, A.; Salinas, Pablo; Dı́az-Cabiale, Zaida; Narváez, José Ángel; Coveñas, Rafael

doi:10.1007/s00429-012-0388-3

Cited by 12 publications

(20 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As previously reported (Duque et al, 2013;Coveñas et al, 2014), mapping was carried out according to Haines' atlas of the human brain and the same atlas was used for the terminology of the brainstem nuclei (Haines, 2012). The number of immunoreactive cell bodies appearing was counted and neuronal density was classified as previously reported (Coveñas et al, 2014): a high density of immunoreactive perikarya was considered when more than 20 profiles/region/section/nucleus were found; density was considered to be moderate when 10-20 profiles/region/section/nucleus were found, and density was low when fewer than 10 profiles/region/section/nucleus were found.…”

Section: Mappingmentioning

confidence: 99%

Developmental study of vitamin C distribution in children's brainstems by immunohistochemistry

Coveñas

González-Fuentes

Infante

et al. 2015

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

Section: Mappingmentioning

confidence: 99%

Developmental study of vitamin C distribution in children's brainstems by immunohistochemistry

Coveñas

González-Fuentes

Infante

et al. 2015

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

“…The distribution of alpha‐neoendorphin‐immunoreactive structures (fibres/perikarya) has been reported in the brainstem of several species (human, monkey, dog, cat) (Coveñas, Duque, Mangas, Marcos, & Narváez, ; Duque et al., ; Marcos et al., ; Pesini, Pego‐Reigosa, Tramu, & Coveñas, ). In many brainstem nuclei of the dog and cat the presence of cell bodies containing alpha‐neoendorphin has been observed (Marcos et al., ; Pesini et al., ).…”

Section: Discussionmentioning

confidence: 98%

“…In the brainstem of both species a more widespread distribution of cell bodies containing alpha‐neoendorphin was observed in comparison with that found in primates (monkey, human); this was due to the administration of colchicine in the dog and cat. In the brainstem of humans and monkeys (not treated with colchicine), the distribution of alpha‐neoendorphin‐immunoreactive perikarya was very restricted: cell bodies containing the peptide were only observed in the medullary central gray matter/spinal trigeminal nucleus (human) and in the latter nucleus (monkey) (Coveñas et al., ; Duque et al., ). However, in alpacas not treated with the drug, no immunoreactive cell body was observed in the brainstem.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the distribution of alpha‐neoendorphin‐immunoreactive fibres in the mammalian brainstem, it seems that in general this distribution is quite similar in human, monkey, dog and cat (Coveñas et al., ; Duque et al., ; Marcos et al., ; Pesini et al., ). In comparison with these species, the distribution found in the alpaca brainstem is quite similar to that observed in the monkey and a slightly widespread (e.g., reticular formation) in comparison with human, dog and cat.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison with these species, the distribution found in the alpaca brainstem is quite similar to that observed in the monkey and a slightly widespread (e.g., reticular formation) in comparison with human, dog and cat. In general, in most of the brainstem nuclei of human, monkey, dog and cat, a low the density of alpha‐neoendorphin‐immunoreactive fibres has been observed (Coveñas et al., ; Duque et al., ; Marcos et al., ; Pesini et al., ). This is in agreement with the results found in the alpaca brainstem.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Distribution of alpha‐neoendorphin, ACTH (18–39) and beta‐endorphin (1–27) in the alpaca brainstem

Sánchez

Souza

Aguilar

et al. 2018

Anat Histol Embryol

Self Cite

View full text Add to dashboard Cite

Using an immunocytochemical technique, we have studied in the alpaca brainstem the distribution of immunoreactive structures containing prodynorphin (alpha-neoendorphin)- and pro-opiomelanocortin (adrenocorticotrophin hormone (18-39) (ACTH), beta-endorphin (1-27))-derived peptides. No peptidergic-immunoreactive cell body was observed. Immunoreactive fibres were widely distributed, although in most of the brainstem nuclei the density of the peptidergic fibres was low or very low. In general, the distribution of the immunoreactive fibres containing the peptides studied was very similar. A close anatomical relationship occurred among the fibres containing alpha-neoendorphin, ACTH or beta-endorphin (1-27), suggesting a functional interaction among the three peptides in many of the brainstem nuclei. The number of fibres belonging to the prodynorphin system was higher than that of the pro-opiomelanocortin system. A moderate/low density of immunoreactive fibres was observed in 65.11% (for alpha-neoendorphin (1-27)), 18.18% (for ACTH) and 13.95% (for beta-endorphin) of the brainstem nuclei/tracts. In the alpaca brainstem, a high density of immunoreactive fibres was not observed. The neuroanatomical distribution of the immunoreactive fibres suggests that the peptides studied are involved in auditory, motor, gastric, feeding, vigilance, stress, respiratory and cardiovascular mechanisms, taste response, sleep-waking cycle and the control of pain transmission.

show abstract

Interactions Between Kisspeptins and Neurokinin B

Navarro

2013

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Reproductive function is tightly regulated by an intricate network of central and peripheral factors; however, the precise mechanism triggering critical reproductive events, such as puberty onset, remains largely unknown. Recently, the neuropeptides kisspeptin (encoded by Kiss1) and neurokinin B (NKB, encoded by TAC3 in humans and Tac2 in rodents) have been placed as essential gatekeepers of puberty. Studies in humans and rodents have revealed that loss-of-function mutations in the genes encoding either kisspeptin and NKB or their receptors, Kiss1r and neurokinin 3 receptor (NK3R), lead to impaired sexual maturation and infertility. Kisspeptin, NKB, and dynorphin A are co-expressed in neurons of the arcuate nucleus (ARC), so-called K isspeptin/N KB/Dyn (KNDy) neurons. Importantly, these neurons also co-express NK3R. Compelling evidence suggests a stimulatory role of NKB (or the NK3R agonist, senktide) on LH release in a number of species. This effect is likely mediated by autosynaptic inputs of NKB on KNDy neurons to induce the secretion of gonadotropin-releasing hormone (GnRH) in a kisspeptin-dependent manner, with the coordinated actions of other neuroendocrine factors, such as dynorphin, glutamate, or GABA. Thus, we have proposed a model in which NKB feeds back to the KNDy neuron to shape the pulsatile release of kisspeptin, and hence GnRH, in a mechanism also dependent on the sex steroid level. Additionally, NKB may contribute to the regulation of the reproductive function by metabolic cues. Investigating how NKB and kisspeptin interact to regulate the gonadotropic axis will offer new insights into the control of GnRH release during puberty onset and the maintenance of the reproductive function in adulthood, offering a platform for the understanding and treatment of a number of reproductive disorders.

show abstract

Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem

Cited by 12 publications

References 34 publications

Developmental study of vitamin C distribution in children's brainstems by immunohistochemistry

Developmental study of vitamin C distribution in children's brainstems by immunohistochemistry

Distribution of alpha‐neoendorphin, ACTH (18–39) and beta‐endorphin (1–27) in the alpaca brainstem

Interactions Between Kisspeptins and Neurokinin B

Contact Info

Product

Resources

About