Mapping of sensory-responsive cells in the septal area of the rat

Mercer, L.F.; Remley, N.R.

doi:10.1016/0361-9230(79)90032-7

Cited by 18 publications

(10 citation statements)

References 27 publications

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“…This suggests that direct contact with pups and the performance of maternal behavior, but not distal stimulation from pups or general physical activity, stimulate high levels of Fos expression in these areas. In support of this interpretation, most of the neural sites we investigated that showed increased Fos-ir after mother-litter interactions are electrophysiologically responsive to peripheral tactile input [mPOA: 47]; BST: 47], 48]; cPAG: 49, 50]; LHb: 51]; LS: 52]. Furthermore, there is differential somatosensory regulation of c-fos activity in some sites of the maternal rat brain.…”

Section: Discussionmentioning

confidence: 77%

Maternal Behavior Stimulates <i>c-fos</i> Activity within Estrogen Receptor Alpha-Containing Neurons in Lactating Rats

et al. 2000

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Estradiol and other hormones are thought to be critical for the onset, but not maintenance, of maternal behavior in rats. Maternal behavior is instead maintained postpartum by tactile stimulation that dams receive during interactions with pups, and many neural sites implicated in the control of maternal behavior show elevated c-fos activity in response to this stimulation. Many of these sites also contain neurons that express the alpha subtype of the estrogen receptor (ERα). Because of possible interactions between tactile stimulation from pups, c-fos, and ERα in the lactating rat brain, we determined if populations of cells that show increased c-fos activity after maternal behavior in lactating rats also contain ERα. Dams were separated from their pups for 48 h beginning on day 5 postpartum. On day 7 postpartum, experimental dams were reunited with pups and mother-litter interactions were observed for 60 min. Control dams received no pup stimulation. Subjects were sacrificed 60 min later and brain sections were double immunolabeled for the Fos and ERα proteins. As expected, the number of ERα-immunoreactive (ERα-ir) neurons did not differ between the two groups in the eight areas analyzed (lateral region of the lateral septum, posterodorsal medial amygdala, dorsal and ventral medial preoptic area, dorsal and ventral bed nucleus of the stria terminalis, lateral habenula, and ventrolateral caudal periaqueductal gray). Consistent with previous reports, maternal dams had 2- to 7-fold more Fos-immunoreactive (Fos-ir) neurons in these sites compared with nonstimulated controls. Maternal dams had significantly more Fos-ir neurons that also contained ERα-ir in all sites, with the greatest increases in the ventral medial preoptic area, lateral habenula, and ventral bed nucleus of the stria terminalis. Between ∼25 and 45% of the Fos-ir cells in the sites examined also expressed ERα. Thus, a substantial number of neurons that are genomically activated during maternal behavior contain ERα, raising the possibility that the postpartum display of maternal behavior can be influenced by ERα activity.

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Section: Discussionmentioning

confidence: 77%

Maternal Behavior Stimulates <i>c-fos</i> Activity within Estrogen Receptor Alpha-Containing Neurons in Lactating Rats

et al. 2000

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“…Medial septal neurons, which project to the hippocampus through FF fibers, increase their firing rates in response to various sensory stimuli, including sound, touch, and light [18,19]. An imaging study demonstrated that medial septal GABAergic fibers projecting to CA1 stratum oriens respond to sensory inputs with transient calcium elevations [20].…”

Section: Resultsmentioning

confidence: 98%

Sound-induced modulation of hippocampal θ oscillations

Abe

Sakaguchi²,

Kitajo³

et al. 2014

NeuroReport

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The mechanism of response of hippocampal neurons to a specific feature in sensory stimuli is not fully understood, although the hippocampus is well known to contribute to the formation of episodic memory in the multisensory world. Using in-vivo voltage-clamp recordings from awake mice, we found that sound pulses induced a transient increase in inhibitory, but not excitatory, conductance in hippocampal CA1 pyramidal cells. In local field potentials, sound pulses induced a phase resetting of the θ oscillations, one of the major oscillatory states of the hippocampus. Repetitive sound pulses at 7 Hz (θ rhythm) increased the θ oscillation power, an effect that was abolished by a surgical fimbria-fornix lesion. Thus, tone-induced inhibition is likely of subcortical origin. It may segment hippocampal neural processing and render temporal boundaries in continuously ongoing experiences.

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“…Because medial-septal neurons fire in response to various sensory stimuli [11,12], the medial septum is a candidate brain area that mediates sound-induced hyperpolarization in the hippocampus. Indeed, hippocampal GABAergic afferents from the medial septum are responsive to auditory stimulation [8].…”

Section: Discussionmentioning

confidence: 99%

“…Medial-septal neurons, which project to the hippocampus through FF fibers, increase their firing rates in response to various sensory stimuli, including sound, touch, and light [11,12]. A recent imaging study demonstrated that medial-septal fibers projecting to CA1 stratum oriens respond to sensory inputs with transient calcium elevations [8,13].…”

Section: Lack Of Hippocampal Tone Responses In Fimbria-fornixlesionedmentioning

confidence: 98%

Sound-induced hyperpolarization of hippocampal neurons

Abe

Sakaguchi²,

Matsumoto³

et al. 2014

NeuroReport

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The hippocampus is involved in episodic memory, which is composed of subjective experiences in the multisensory world; however, little is known about the subthreshold membrane potential responses of individual hippocampal neurons to sensory stimuli. Using in-vivo whole-cell patch-clamp recordings from hippocampal CA1 neurons in awake mice, we found that almost all hippocampal neurons exhibited a hyperpolarization of 1-2 mV immediately after the onset of a sound. This large-scale hyperpolarization was unaffected by the duration or pitch of the tone. The response was abolished by general anesthesia and a surgical fimbria-fornix lesion.

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Mapping of sensory-responsive cells in the septal area of the rat

Cited by 18 publications

References 27 publications

Maternal Behavior Stimulates <i>c-fos</i> Activity within Estrogen Receptor Alpha-Containing Neurons in Lactating Rats

Maternal Behavior Stimulates <i>c-fos</i> Activity within Estrogen Receptor Alpha-Containing Neurons in Lactating Rats

Sound-induced modulation of hippocampal θ oscillations

Sound-induced hyperpolarization of hippocampal neurons

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