Sanitation remains
a global challenge, both in terms of access to toilet facilities and
resource intensity (e.g., energy consumption) of waste treatment.
Overcoming barriers to universal sanitation coverage and sustainable
resource management requires approaches that manage bodily excreta
within coupled human and natural systems. In recent years, numerous
analytical methods have been developed to understand cross-disciplinary
constraints, opportunities, and trade-offs around sanitation and resource
recovery. However, without a shared language or conceptual framework,
efforts from individual disciplines or geographic contexts may remain
isolated, preventing the accumulation of generalized knowledge. Here,
we develop a version of the social-ecological systems framework modified
for the specific characteristics of bodily excreta. This framework
offers a shared vision for sanitation as a human-derived resource
system, where people are part of the resource cycle. Through sanitation
technologies and management strategies, resources including water,
organics, and nutrients accumulate, transform, and impact human experiences
and natural environments. Within the framework, we establish a multitiered
lexicon of variables, characterized by breadth and depth, to support
harmonized understanding and development of models and analytical
approaches. This framework’s refinement and use will guide
interdisciplinary study around sanitation to identify guiding principles
for sanitation that advance sustainable development at the nature-society
interface.