Mapping quantitative trait loci affecting fatness and breast muscle 
weight   in meat-type chicken lines divergently selected on abdominal fatness

Lagarrigue, Sandrine; Pitel, Frédérique; Carré, Wilfrid; Abasht, Behnam; Roy, Pascale Le; Neau, André; Amigues, Yves; Sourdioux, M.; Simon, Jean; Cogburn, Larry A.; Aggrey, S. E.; Leclercq, B.; Vignal, Alain; Douaire, Madeleine

doi:10.1051/gse:2005028

Cited by 21 publications

(30 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of studies reported significant QTL effects in the 167–179 Mb region of GGA1. Uemoto et al also detected QTL affecting BW42 and BW63 in 165–172 Mb on GGA1 [11], and QTL effects were also reported in these regions were associated with BW28–BW84, average daily gain, WW or BMW [2], [6], [7], [10], [11], [15]. Besnier et al reported a QTL for BW56 in the 169–175 Mb region of GGA1 with the most significant QTL effect at position 173,709,609 bp on GGA1 [35].…”

Section: Discussionmentioning

confidence: 96%

Genome-Wide Association Study Identified a Narrow Chromosome 1 Region Associated with Chicken Growth Traits

et al. 2012

View full text Add to dashboard Cite

Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still a challenge. In this genome-wide association study (GWAS), we identified a narrow 1.5 Mb region (173.5–175 Mb) of chicken (Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0–90 d of age measured weekly, biweekly average daily gains (ADG) derived from weekly body weight, and breast muscle weight (BMW), leg muscle weight (LMW) and wing weight (WW) at 90 d of age. Five SNPs in the 1.5 Mb KPNA3-FOXO1A region at GGA1 had the highest significant effects for all growth traits in this study, including a SNP at 8.9 Kb upstream of FOXO1A for BW at 22–48 d and 70 d, a SNP at 1.9 Kb downstream of FOXO1A for WW, a SNP at 20.9 Kb downstream of ENSGALG00000022732 for ADG at 29–42 d, a SNP in INTS6 for BW at 90 d, and a SNP in KPNA3 for BMW and LMW. The 1.5 Mb KPNA3-FOXO1A region contained two microRNA genes that could bind to messenger ribonucleic acid (mRNA) of IGF1, FOXO1A and KPNA3. It was further indicated that the 1.5 Mb GGA1 region had the strongest effects on chicken growth during 22–42 d.

show abstract

Section: Discussionmentioning

confidence: 96%

Genome-Wide Association Study Identified a Narrow Chromosome 1 Region Associated with Chicken Growth Traits

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Here we validated this EM correction with experimental data, which has seldom been achieved to date. Another approach to correct the overestimation of QTL contributions was proposed by Lagarrigue et al (2006) for QTL detected in chicken. It is based on the hypothesis of strict truncations of the normal distribution, i.e., a situation that was not adapted to our experimental conditions.…”

Section: Qtl Contributions To Phenotypic Variationmentioning

confidence: 99%

Inheritance studies of apple scab resistance and identification ofRvi14, a new major gene that acts together with other broad-spectrum QTL

Soufflet-Freslon

Gianfranceschi

Patocchi

et al. 2008

Genome

View full text Add to dashboard Cite

Scab, caused by the fungal pathogen Venturia inaequalis, is the most common disease of cultivated apple (Malus xdomestica). The fungal races 6 and 7 have now overcome the major resistance gene Vf, which is widely used in apple breeding programmes. New breeding strategies to achieve durable resistance are thus necessary. The aim of this study was to determine the genetic basis of quantitative resistance of the apple cultivar 'Dülmener Rosenapfel', known to be scab resistant under different environmental conditions. An F1 progeny derived from the cross between the susceptible cultivar 'Gala' and 'Dülmener Rosenapfel' was tested in a greenhouse with a multi-isolate inoculum of V. inaequalis. Rvi14, a new major gene that conditions a chlorotic-type reaction, was mapped on linkage group (LG) 6 in a genomic region not known to be involved in disease resistance. A further three quantitative trait loci (QTL) for resistance were identified. One co-localized with Rvi14 on LG6, whereas the remaining two were detected on LG11 and LG17, in genomic regions already reported to carry broad-spectrum QTL in other genetic backgrounds. Since a selective genotyping approach was used to detect QTL, an expectation-maximization (EM) computation was used to estimate the corrected QTL contributions to phenotypic variation and was validated by entire progeny genotyping.

show abstract

“…Although QTL mapping has been very successful in domestic animals for many complex quantitative traits and a few prominent findings have been reported [11], [12], [13], [14], identification of quantitative trait mutations (QTMs) is still a challenge due to the commonly existing limitations of linkage analysis [15]. Recently, the first high-density 60 K porcine SNP array has been developed [16], which offers the prerequisite of genome-wide association study (GWAS) in swine, a powerful approach for high-resolution mapping of loci controlling phenotypic traits.…”

Section: Introductionmentioning

confidence: 99%

A Genome-Wide Association Study Identifies Two Novel Promising Candidate Genes Affecting Escherichia coli F4ab/F4ac Susceptibility in Swine

Liu

Lü

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

Enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbria is the major pathogenic bacteria causing diarrhoea in neonatal and post-weaning piglets. Previous studies have revealed that the susceptibility to ETEC F4ab/F4ac is an autosomal Mendelian dominant trait and the loci controlling the F4ab/F4ac receptor are located on SSC13q41, between markers SW207 and S0283 . To pinpoint these loci and further validate previous findings, we performed a genome-wide association study (GWAS) using a two generation family-based population, consisting of 301 piglets with phenotypes of susceptibility to ETEC F4ab/F4ac by the vitro adhesion test. The DNA of all piglets and their parents was genotyped using the Illumina PorcineSNP60 BeadChip, and 50,972 and 50,483 SNPs were available for F4ab and F4ac susceptibility, respectively, in the association analysis after quality control. In summary, 28 and 18 significant SNPs ( p <0.05) were detected associated with F4ab and F4ac susceptibility respectively at genome-wide significance level. From these significant findings, two novel candidate genes, HEG1 and ITGB5 , were firstly identified as the most promising genes underlying F4ab/F4ac susceptibility in swine according to their functions and positions. Our findings herein provide a novel evidence for unravelling genetic mechanism of diarrhoea risk in piglets.

show abstract

Mapping quantitative trait loci affecting fatness and breast muscle weight in meat-type chicken lines divergently selected on abdominal fatness

Cited by 21 publications

References 12 publications

Genome-Wide Association Study Identified a Narrow Chromosome 1 Region Associated with Chicken Growth Traits

Genome-Wide Association Study Identified a Narrow Chromosome 1 Region Associated with Chicken Growth Traits

Inheritance studies of apple scab resistance and identification ofRvi14, a new major gene that acts together with other broad-spectrum QTL

A Genome-Wide Association Study Identifies Two Novel Promising Candidate Genes Affecting Escherichia coli F4ab/F4ac Susceptibility in Swine

Contact Info

Product

Resources

About