1999
DOI: 10.1073/pnas.96.24.14067
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Mapping regions containing binding residues within functional domains of Plasmodium vivax and Plasmodium knowlesi erythrocyte-binding proteins

Abstract: Invasion of erythrocytes by malaria parasites is mediated by specific molecular interactions. Whereas Plasmodium vivax and Plasmodium knowlesi use the Duffy blood group antigen, Plasmodium falciparum uses sialic acid residues of glycophorin A as receptors to invade human erythrocytes. P. knowlesi uses the Duffy antigen as well as other receptors to invade rhesus erythrocytes by multiple pathways. Parasite ligands that bind these receptors belong to a family of erythrocyte-binding proteins (EBP). The EBP family… Show more

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Cited by 109 publications
(97 citation statements)
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“…For example, although PkNBPXa and DBPa proteins bind to both human and macaque RBCs, DBPβ, DBPγ, and NBPXb bind only to macaque RBCs (16,39). This apparent lack of adhesin redundancy for human RBC invasion suggests that P. knowlesi is vulnerable to perturbation of DBPα/NBPXa function.…”
Section: Discussionmentioning
confidence: 99%
“…For example, although PkNBPXa and DBPa proteins bind to both human and macaque RBCs, DBPβ, DBPγ, and NBPXb bind only to macaque RBCs (16,39). This apparent lack of adhesin redundancy for human RBC invasion suggests that P. knowlesi is vulnerable to perturbation of DBPα/NBPXa function.…”
Section: Discussionmentioning
confidence: 99%
“…Critical binding motifs in PvDBPII have been mapped to a 170 amino acid stretch (amino acids 291-460), which includes cysteines 5-8 [11,12]. PvDBPII shows the highest genetic diversity compared to the remaining PvDBP regions and appears to be under strong selective pressure [13,14].…”
Section: Introductionmentioning
confidence: 99%
“…Adhesion to DA is mediated by the 140-kDa PvDBP (6)(7)(8). The receptor-binding domain of PvDBP maps to the conserved, N-terminal cysteine-rich region II (PvDBPII) (9,10). Given the complete dependence of P. vivax on the PvDBPII-Duffy interaction for blood-stage infection and recent observations that PvDBPII-specific antibodies inhibit P. vivax invasion of human erythrocytes in vitro (11), we examined the hypothesis that naturally acquired PvDBPII-specific binding inhibitory antibodies (BIAbs) are associated with protection against P. vivax infection in vivo.…”
mentioning
confidence: 99%