Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT.

Jeffery, Petra J.; Monsein, Lee H.; Szabó, Zsolt; Hart, John; Fisher, Robert S.; Lesser, Ronald P.; Debrun, Gérard; Gordon, Barry; Wagner, Henry N.; Camargo, Edwaldo E.

doi:10.1148/radiology.178.3.1994430

Cited by 61 publications

(26 citation statements)

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“…These data are consistent with findings from previous single photon emission computed tomography (SPECT) studies (Kim, Lee, Nam, Song, & Lee, 1999;Urbach et al, 1999;Jeffrey et al, 1991). These studies strongly suggest that (in the absence of a direct ''fetal'' origin of the PCA from the ICA) an amytal injection into the ICA does not perfuse most of the medial temporal lobe, including most of the hippocampus and its associated cortex, but does anesthetize other cortical regions including the frontal and parietal cortex.…”

Section: Discussionsupporting

confidence: 90%

Wada Testing Reveals Frontal Lateralization for the Memorization of Words and Faces

Kelley

Ojemann

Wetzel

et al. 2002

Journal of Cognitive Neuroscience

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Abstract& Neuroimaging studies have suggested that specific regions of the frontal and medial temporal cortex are engaged during memory formation. Further, there is specialization across these regions such that verbal materials appear to preferentially engage the left regions while nonverbal materials primarily engage the right regions. An open question, however, has been to what extent frontal regions contribute to successful memory formation. The present study investigates this question using a reversible lesion technique known as the Wada test. Patients memorized words and unfamiliar faces while portions of their left and right hemispheres were temporarily anesthetized with sodium amytal. Subsequent memory tests revealed that faces were remembered better than words following left-hemisphere anesthesia, whereas words were remembered better than faces following right-hemisphere anesthesia. Importantly, inspection of the circulation affected by the amytal further suggests that these memory impairments did not result from direct anesthetization of the medial temporal regions. Taken in the context of the imaging findings, these results suggest that frontal regions may also contribute to memory formation in normal performance. &

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Section: Discussionsupporting

confidence: 90%

Wada Testing Reveals Frontal Lateralization for the Memorization of Words and Faces

Kelley

Ojemann

Wetzel

et al. 2002

Journal of Cognitive Neuroscience

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“…Radiouptake resulting from the injection of this tracer mixed with sodium amobarbital, therefore, directly reflects the distribution of sodium amobarbital. Jeffery et al (12) demonstrated that this method was more reliable than conventional angiography for assessing the distrbution of sodium amobarbital. They reported that the medial temporal regions were irrigated by sodium amobarbital in only 28% of the patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Functional Changes in the Medial Temporal Region During Intracarotid Amobarbital Procedure by Use of SPECT

et al. 1999

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Summary: Purpose: Because the main blood supply to the medial temporal region is through the posterior cerebral artery, the validity of the intracarotid amobarbital procedure (IAP) is still debated. To verify clinical validity of the IAP, we investigated changes in neuronal function in the medial temporal region during IAP.Methods: Brain single photon emission computed tomography (SPECT) was performed during IAP (IAP-SPECT) in 22 patients with temporal lobe epilepsy (TLE), and regional cerebral blood flow (rCBF) in the medial and lateral temporal regions of interest (ROIs) was measured quantitatively. To determine the distribution of sodium amobarbital, in another 20 patients with TLE, SPECT images were obtained after intracarotid injection of 99"Tc-HMPA0 mixed with sodium amobarbital.Results: Mean rCBF was 89.2% in the medial temporal region and 81.6% in the lateral temporal region; in the former region, it was significantly lower than that shown by the results of interictal SPECT (99.1%; p c 0.001). In a few patients, however, rCBF did not decrease in the medial temporal region. In only 25% of patients, the medial temporal region was visualized in SPECT images obtained after intracarotid injection of Conclusions:The results in this study demonstrate that IAP is valid because the medial temporal region is inactivated in spite of infrequent delivery of sodium amobarbital. We assume that intratemporal diaschisis is operating for the inactivation of neuronal function. IAP-SPECT with intratemporal ROIs may be useful for monitoring changes in neuronal function in the medial temporal region during TAP.

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“…4) (21,22). In particular, the mesiobasal TL structures showed inconsistent barbiturate perfusion, varying between 72 and 18% after the IAP.…”

Section: Discussionmentioning

confidence: 99%

Selective Amobarbital Test for the Determination of Language Function in Patients with Epilepsy with Frontal and Posterior Temporal Brain Lesions

et al. 1998

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Summary:Purpose: Selective amobarbital tests with selective temporary inactivation of the left frontal operculum and/or the left parietotemporal cortex were performed in 5 patients with left-hemispheric epileptogenic lesions in or adjacent to classical Broca's and/or Wemicke's area. The aim was to assess language functions in these brain regions before surgery, to tailor the surgery according to the individual functional importance of these brain regions, and to predict postoperative outcome.Methods: Amobarbital was injected by transfemoral selective catheterization of the arteries supplying the target areas. Along with neuropsychological and neurological testing during the amobarbital procedure, EEG recordings were performed in all patients, and [99"Tc]HMPAO-single photon emission computed tomography (SPECT) in 2 patients.

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Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT.

Cited by 61 publications

References 0 publications

Wada Testing Reveals Frontal Lateralization for the Memorization of Words and Faces

Wada Testing Reveals Frontal Lateralization for the Memorization of Words and Faces

Evaluation of Functional Changes in the Medial Temporal Region During Intracarotid Amobarbital Procedure by Use of SPECT

Selective Amobarbital Test for the Determination of Language Function in Patients with Epilepsy with Frontal and Posterior Temporal Brain Lesions

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