2010
DOI: 10.1111/j.1476-5381.2009.00549.x
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Mapping the high‐affinity binding domain of 5‐substituted benzimidazoles to the proximal N‐terminus of the GluN2B subunit of the NMDA receptor

Abstract: Background and purpose: N-methyl-D-aspartate Experimental approach:The pharmacological antagonistic profiles of XK1 and XK2 were assessed using in vitro rat primary cerebrocortical neurones and two-electrode voltage clamp on Xenopus oocytes expressing heterologous GluN1/GluN2B receptors. Direct ligand binding was determined using the recombinant amino-terminal domain (ATD) of GluN2B. Key results: XK1 and XK2 effectively protected against NMDA-induced excitotoxicity in rat primary cortical neurones. Low concent… Show more

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Cited by 8 publications
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References 58 publications
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