Mapping the sensitive volume of an ion-counting nanodosimeter

Schulte, R.; Bashkirov, V.; Shchemelinin, S.; Breskin, A.; Chechik, R.; Garty, Guy; Wroe, Andrew; Großwendt, B.

doi:10.1088/1748-0221/1/04/p04004

Cited by 10 publications

(9 citation statements)

References 10 publications

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“…Compared to a previous investigation of the spatial distribution of the extraction efficiency with an almost identical device (Schulte et al 2006), the shape and lateral extension of the two distributions are similar over the range covered by both devices. The deviation between measurement and simulation found in the present investigation is, however, smaller (see figure 8 in Schulte et al (2006), which shows the result for operational conditions closest to those in this work). Owing to the different experimental conditions in Schulte et al (2006) and this work, only a qualitative comparison is possible.…”

Section: Effective Size Of the Target Volumecontrasting

confidence: 42%

Measurement of track structure parameters of low and medium energy helium and carbon ions in nanometric volumes

2017

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Ionization cluster size distributions produced in the sensitive volume of an ion-counting wall-less nanodosimeter by monoenergetic carbon ions with energies between 45 MeV and 150 MeV were measured at the TANDEM-ALPI ion accelerator facility complex of the LNL-INFN in Legnaro. Those produced by monoenergetic helium ions with energies between 2 MeV and 20 MeV were measured at the accelerator facilities of PTB and with a Am alpha particle source. CH was used as the target gas. The ionization cluster size distributions were measured in narrow beam geometry with the primary beam passing the target volume at specified distances from its centre, and in broad beam geometry with a fan-like primary beam. By applying a suitable drift time window, the effective size of the target volume was adjusted to match the size of a DNA segment. The measured data were compared with the results of simulations obtained with the PTB Monte Carlo code PTra. Before the comparison, the simulated cluster size distributions were corrected with respect to the background of additional ionizations produced in the transport system of the ionized target gas molecules. Measured and simulated characteristics of the particle track structure are in good agreement for both types of primary particles and for both types of the irradiation geometry. As the range in tissue of the ions investigated is within the typical extension of a spread-out Bragg peak, these data are useful for benchmarking not only 'general purpose' track structure simulation codes, but also treatment planning codes used in hadron therapy. Additionally, these data sets may serve as a data base for codes modelling the induction of radiation damages at the DNA-level as they almost completely characterize the ionization component of the nanometric track structure.

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Section: Effective Size Of the Target Volumecontrasting

confidence: 42%

Measurement of track structure parameters of low and medium energy helium and carbon ions in nanometric volumes

2017

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“…The SV is defined by the threedimensional distribution of ion collection efficiency (Fig. 2b), which has been both measured and calculated using a Monte Carlo ion transport code with good agreement of both data sets [11]. The ion origin along the SV is derived from its drift-time measurement; selection of certain drift-time limits permits segmenting the full-length SV into shorter sub-volumes [9,10].…”

Section: Methodsmentioning

confidence: 99%

Nanodosimetry-based quality factors for radiation protection in space

Schulte

Wroe

Bashkirov

et al. 2008

Zeitschrift für Medizinische Physik

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“…The actual shape and size of the SV in the gas is determined by the size of the aperture, the drift field , the accelerating field and the ion counter efficiency. This was evaluated experimentally as a 3 D ion registration efficiency map as described in detail in (10). Two turbo-molecular pumps (not shown) generate the pressure gradient between the 1.33 mbar gas volume and , which is required for operation of the ion counter.…”

Section: A the Tracking Ion Counting Nanodosimeter-design And Princimentioning

confidence: 99%

Experimental Validation of Track Structure Models

Bashkirov

Schulte

Wroe

et al. 2009

IEEE Trans. Nucl. Sci.

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A tracking ion counting nanodosimeter was employed to acquire spatial ionization patterns produced by charged particles in propane gas at 1.3 mbar. Data were taken at the James M. Slater MD Proton Treatment and Research Center with 250 MeV, 17 MeV, 5 MeV and 1.5 MeV proton beams, 4.8 MeV alpha particles and electrons from a Sr-90/Y-90 source. For each particle type, measurable quantities used for track structure reconstruction included the number of ionizations and their location within a wall-less, cylindrical sensitive volume measured with a resolution of about 5 tissue-equivalent nanometers, and primary particle coordinates. Measured ionization frequency distributions as a function of distance from particle track were compared with results of a dedicated Monte Carlo track structure code.

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Mapping the sensitive volume of an ion-counting nanodosimeter

Cited by 10 publications

References 10 publications

Measurement of track structure parameters of low and medium energy helium and carbon ions in nanometric volumes

Measurement of track structure parameters of low and medium energy helium and carbon ions in nanometric volumes

Nanodosimetry-based quality factors for radiation protection in space

Experimental Validation of Track Structure Models

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