Mapping the spreading routes of lymphatic metastases in human colorectal cancer

Zhang, Chong; Zhang, Lin; Xu, Tianlei; Xue, Ruidong; Yu, Liang; Zhu, Yue-lu; Wu, Yiping; Zhang, Qingqing; Li, Dongdong; Shen, Shuohao; Tan, Dongfeng; Bai, Fan; Zhang, Haizeng

doi:10.1038/s41467-020-15886-6

Cited by 74 publications

(49 citation statements)

References 56 publications

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“…Another investigation of the patterns of metastasis in colon cancer patients showed that liver metastasis could originate directly from the primary tumor or from LNMs. These data also showed the LNMs can also seed other LNs, including those in the same regional bed or more proximally (“skip spreading”) [ 145 ]. In addition, two back-to-back studies performed genomic analyses using breast cancer patient primary tumors and metastatic lesion samples to build the evolutionary history of the metastatic lesions.…”

Section: Lymph Node Metastasismentioning

confidence: 99%

Progression of Metastasis through Lymphatic System

Zhou

Lei

Padera

2021

Cells

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Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits. In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.

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Section: Lymph Node Metastasismentioning

confidence: 99%

Progression of Metastasis through Lymphatic System

Zhou

Lei

Padera

2021

Cells

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“…Notably, lymphogenous spread is another prominent pathway for GIC ( 35 , 36 ). One study showed that MOC is related to retroperitoneal lymph node relapses.…”

Section: Metastatic Routementioning

confidence: 99%

Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer

Chen

Zhao

et al. 2020

Front. Oncol.

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Reports indicate that most metastatic ovarian cancer (MOC) originates from gastrointestinal cancer (GIC). Notably, GICs metastasize to the ovary frequently via 3 main routes including hematogenous spread, lymphogenous spread, and transcoelomic spread. Nonetheless, the mechanism of the progression remains unknown, and only a handful of literature exists on the molecular alteration implicated in MOC from GIC. This work collected existing evidence and literature on the vital molecules of the metastatic pathway and systematically analyzed them geared toward exploring the mechanism of the metastatic pathway of MOC. Further, this review described dominating molecular alteration in the metastatic process from cancer cells detaching away from lesions to arrive at the ovary, including factors for regulating signaling pathways in epithelial-interstitial transformation, invading, and surviving in the circulatory system or abdominal cavity. We interrogated the basis of the ovary as a distant metastatic site. This article provides new insights into the metastatic pathway and generates novel therapeutic targets for effective treatment and satisfactory outcomes in GIC patients.

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“…Tumor metastasis is a complex process; one of the significant developmental program is EMT, which permits invasion and migration of cancer cells (Aiello et al, 2018;Pastushenko et al, 2018), and is associated with poor prognosis (Yang and Weinberg, 2008;Singh and Settleman, 2010;De Craene and Berx, 2013;Shang et al, 2019). Tumor progression is regulated by several biomolecules, whose mechanisms are mostly unknown (Zhang C. et al, 2020). Therefore, there is an urgent need to clarify the mechanisms underlying CRC progression.…”

Section: Introductionmentioning

confidence: 99%

LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway

Duan

Kong

et al. 2020

Front. Cell Dev. Biol.

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Accumulating literatures have indicated that long non-coding RNAs (lncRNAs) are crucial molecules in tumor progression in various human cancers, including colorectal cancer (CRC). However, the clinical significance and regulatory mechanism of a vast majority of lncRNAs in CRC remain to be determined. The current study aimed to explore the function and molecular mechanism of lncRNA AC010789.1 in CRC progression. AC010789.1 found to be overexpressed in CRC tissues and cells. High expression of AC010789.1 was associated with lymph node metastasis and poor prognosis. Moreover, AC010789.1 silencing inhibited proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro as well as tumorigenesis and metastasis in vivo. Mechanistically, we demonstrated that repression of AC010789.1 promoted miR-432-3p expression, and miR-432-3p directly binds to ZEB1. We then proved the anti-tumor role of miR-432-3p in CRC, showing that the inhibitory effect of AC010789.1 knockdown on CRC cells was achieved by the upregulation of miR-432-3p but downregulation of ZEB1. We also established that silencing AC010789.1 suppressed the Wnt/β-catenin signaling pathway. However, this inhibitory effect was partially counteracted by inhibition of miR-432-3p. In summary, these results reveal that silencing AC010789.1 suppresses CRC progression via miR-432-3p-mediated ZEB1 downregulation and suppression of the Wnt/β-catenin signaling pathway, highlighting a potentially promising strategy for CRC treatment.

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Mapping the spreading routes of lymphatic metastases in human colorectal cancer

Cited by 74 publications

References 56 publications

Progression of Metastasis through Lymphatic System

Progression of Metastasis through Lymphatic System

Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer

LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway

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