Mapping transitions between healthy and pathological lesions in human breast tissues by diffraction enhanced imaging computed tomography (DEI-CT) and small angle x-ray scattering (SAXS)

Conceição, A.L.C.; Antoniassi, M.; Geraldelli, W.; Poletti, M.E.

doi:10.1016/j.radphyschem.2013.02.025

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…In medical applications, several studies [23][24][25][26] have shown that there exist significant differences in the scatter signatures from cancerous and healthy tissue, for example in the blood [2], bone [27] and breast [28]. In addition, studies have shown that scatter imaging can be used to spatially resolve different materials using tomography [29,30] or coded apertures [31].…”

Section: Potential Applications Of X-ray Scatter Imagingmentioning

confidence: 99%

An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

Lakshmanan

Kapadia

Sahbaee

et al. 2014

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Potential Applications Of X-ray Scatter Imagingmentioning

confidence: 99%

An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

Lakshmanan

Kapadia

Sahbaee

et al. 2014

Nuclear Instruments and Methods in Physics Research Section B:

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“…Many works are employing SAXS and WAXS techniques to get information about the structural organization of healthy and pathological human breast tissue. SAXS analysis has been used by groups to reveal changes in collagen fibril d-spacing [2, 3, 4, 5] and variations in the amorphous scattering component [4, 5, 6, 7] that are related to breast cancer development. In addition, WAXS analysis has been used to identify structures like fatty acids and water molecules [8, 9, 10, 11] in an attempt to classify breast samples [10, 12, 13, 14].…”

Section: Introductionmentioning

confidence: 99%

The influence of hydration on the architectural rearrangement of normal and neoplastic human breast tissues

Conceição

Meehan

Antoniassi

et al. 2019

Heliyon

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In adult women, the water-content represents between 50% and 70% of the mass in normal breast tissues and this percentage is increased within diseased tissues. Water molecules play an essential role in the structural organization of biological tissues such as breast. Then, in this study, we have investigated the influence of the water molecules on the breast tissue organization and their role on the hierarchical tissue rearrangement promoted by tumor growth. SAXS and WAXS techniques were used to analyze healthy, benign and malignant human breast samples in native and lyophilized conditions. The scattering profiles in SAXS and WAXS regime of each tissue type in both conditions were compared in order to identify the structural transformation in these tissues and verify the water influence on the morphological arrangement of normal and pathological human breast tissues. From SAXS, changes at the axial periodicity of collagen fibrils were revealed. Additionally, when the water content has removed a peak at q = 4.17 nm −1 (that was present only in pathological samples) shifted in opposite directions within benign and malignant lesions. From WAXS, water and fatty acids were identified within native samples. However, after freeze-drying, only the fat component was observed in the scattering profiles. Therefore, when the water molecules were removed from the samples, structural changes associated with pathological progression were visible. From this, insights about their influence over the changes promoted by the tumor growth have been proposed. Finally, the findings of this study have the potential to provide valuable information to the development of new target therapy.

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“…Although SAXS does not provide images, it captures information of structure sizes averaged over many objects and can therefore be used as a complementary method to conventional imaging techniques. In particular, properties like size, shape and surface contribution can be obtained by SAXS, which can be used in many different applications like in catalysis, 18 protein research, 19,20 biology, [21][22][23] and polymer chemistry. 4,24 In addition to conventional SAXS, Anomalous Small Angle X-ray Scattering (ASAXS) exploits the energy dependence of the scattering cross section.…”

Section: Introductionmentioning

confidence: 99%

Morphological analysis of cerium oxide stabilized nanoporous gold catalysts by soft X-ray ASAXS

et al. 2017

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Mapping transitions between healthy and pathological lesions in human breast tissues by diffraction enhanced imaging computed tomography (DEI-CT) and small angle x-ray scattering (SAXS)

Cited by 10 publications

References 16 publications

An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

An X-ray scatter system for material identification in cluttered objects: A Monte Carlo simulation study

The influence of hydration on the architectural rearrangement of normal and neoplastic human breast tissues

Morphological analysis of cerium oxide stabilized nanoporous gold catalysts by soft X-ray ASAXS

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