Mapping typical and hypokinetic dysarthric speech production network using a connected speech paradigm in functional MRI

Narayana, Shalini; Parsons, Megan Battles; Zhang, Wei; Franklin, Crystal; Schiller, Katherine; Choudhri, Asim F.; Fox, Peter T.; LeDoux, Mark S.; Cannito, Michael P.

doi:10.1016/j.nicl.2020.102285

Cited by 7 publications

(6 citation statements)

References 68 publications

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“…Consistent with our assumption, quantitative methods were predominantly adopted in these studies, while only few employed qualitative or mixed approaches, such as error rate analysis, or presented case and exemplar studies. The common connected speech production measures used for speakers with developmental disorders included behavioral tasks (e.g., story retelling, picture description, word imitation, concurrent commenting, and free conversation), psychiatric rating scales ( De Prete et al, 2021 ), standardized tests ( Kirmess and Lind, 2011 ), corpus analysis, Voxelwise Lesion-Symptom Mapping (VLSM; Stark et al, 2019 ), and functional Magnetic Resonance Imaging (fMRI; Narayana et al, 2020 ). The data drawn from these instruments were processed by various statistical techniques ranging from the K-means algorithm, SPSS, and PRAAT speech software to spectral/cepstral analyses ( Bose et al, 2022 ) for a more accurate and comprehensive evaluation of speech rate, dysfluencies, syntactic, lexical, morphological, and semantic malfunctions.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of studies on connected speech processing: Trends, key findings, and implications

Zare

Kania

et al. 2022

Front. Psychol.

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Connected speech processing (CSP) is of great significance to individuals’ language and cognitive development. It is particularly crucial not only for clinical detection and treatment of developmental disorders, but also for the Foreign/second language teaching instructions. However, given the importance of this field, there is a clear lack of systematic reviews that summarize the key findings of previous studies. To this end, through searching in the scientific databases PsycInfo, Scopus, PubMed, ERIC, Taylor and Francis, and Web of Science, the present study identified 128 core CSP articles with high reference values according to PRISMA guidance and the following results were obtained through quantitative analysis and qualitative comparative synthesis: (1) The number of studies on CSP published per year showed an upward trend; however, most focused on English language, whereas the studies on other languages were comparatively rare; (2) CSP was found to be affected by multiple factors, among which speech speed, semantics, word frequency, and phonological awareness were most frequently investigated; (3) the deficit in CSP capacity was widely recognized as a significant predictor and indicator of developmental disorders; (4) more studies were carried out on connected speech production than on perception; and (5) almost no longitudinal studies have ever been conducted among either native or non-native speakers. Therefore, future research is needed to explore the developmental trajectory of CSP skills of typically developing language learners and speakers with cognitive disorders over different periods of time. It is also necessary to deepen the understanding of the processing mechanism beyond their performance and the role played by phonological awareness and lexical representations in CSP.

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Section: Resultsmentioning

confidence: 99%

A systematic review of studies on connected speech processing: Trends, key findings, and implications

Zare

Kania

et al. 2022

Front. Psychol.

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“…Neuroimaging studies of speech production in PD have reported conflicting findings concerning the level of activation in SMA for PD patients compared to controls, with some studies reporting hypoactivation of SMA ( Baumann et al, 2018 ; Narayana et al, 2020 ), some reporting hyperactivation of SMA ( Liotti et al, 2003 ; Pinto et al, 2004 ; Rektorova et al, 2007 ), and others reporting no group differences in SMA activity between PD and controls ( Pinto et al, 2011 ; Arnold et al, 2014 ; Klobusiakova et al, 2021 ; Manes et al, 2023 ). Regarding voice intensity, Liotti et al (2003) found no differences in BG or SMA activity when comparing loud versus habitual overt speech in participants with PD.…”

Section: Impaired Performance In the Initiation Circuitmentioning

confidence: 99%

A neurocomputational view of the effects of Parkinson’s disease on speech production

Manes,

Bullock,

Meier

et al. 2024

Front. Hum. Neurosci.

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The purpose of this article is to review the scientific literature concerning speech in Parkinson’s disease (PD) with reference to the DIVA/GODIVA neurocomputational modeling framework. Within this theoretical view, the basal ganglia (BG) contribute to several different aspects of speech motor learning and execution. First, the BG are posited to play a role in the initiation and scaling of speech movements. Within the DIVA/GODIVA framework, initiation and scaling are carried out by initiation map nodes in the supplementary motor area acting in concert with the BG. Reduced support of the initiation map from the BG in PD would result in reduced movement intensity as well as susceptibility to early termination of movement. A second proposed role concerns the learning of common speech sequences, such as phoneme sequences comprising words; this view receives support from the animal literature as well as studies identifying speech sequence learning deficits in PD. Third, the BG may play a role in the temporary buffering and sequencing of longer speech utterances such as phrases during conversational speech. Although the literature does not support a critical role for the BG in representing sequence order (since incorrectly ordered speech is not characteristic of PD), the BG are posited to contribute to the scaling of individual movements in the sequence, including increasing movement intensity for emphatic stress on key words. Therapeutic interventions for PD have inconsistent effects on speech. In contrast to dopaminergic treatments, which typically either leave speech unchanged or lead to minor improvements, deep brain stimulation (DBS) can degrade speech in some cases and improve it in others. However, cases of degradation may be due to unintended stimulation of efferent motor projections to the speech articulators. Findings of spared speech after bilateral pallidotomy appear to indicate that any role played by the BG in adult speech must be supplementary rather than mandatory, with the sequential order of well-learned sequences apparently represented elsewhere (e.g., in cortico-cortical projections).

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“…However, reduced voice intensity in PD does not appear to have a consistent or robust response to dopaminergic therapy ( Daniels et al, 1996 ; Kompoliti et al, 2000 ; Skodda et al, 2010 ; Fabbri et al, 2017 ). Moreover, existing neuroimaging studies of speech production in PD have reported mixed findings with respect to motor cortical activation, making it difficult to discern whether reduced vocal intensity is explicitly linked to reduced activity in the motor cortices ( Pinto et al, 2004 ; Rektorova et al, 2007 ; Pinto et al, 2011 ; Arnold et al, 2014 ; Baumann et al, 2018 ; Narayana et al, 2020 ). The variability across studies may be in part due to differences in the clinical presentation of the participants (e.g., whether participants presented with voice symptoms at the time of the study).…”

Section: Introductionmentioning

confidence: 99%

Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson’s disease and hypophonia

Manes,

Kurani,

Herschel

et al. 2023

Front. Hum. Neurosci.

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IntroductionHypophonia is a common feature of Parkinson’s disease (PD); however, the contribution of motor cortical activity to reduced phonatory scaling in PD is still not clear.MethodsIn this study, we employed a sustained vowel production task during functional magnetic resonance imaging to compare brain activity between individuals with PD and hypophonia and an older healthy control (OHC) group.ResultsWhen comparing vowel production versus rest, the PD group showed fewer regions with significant BOLD activity compared to OHCs. Within the motor cortices, both OHC and PD groups showed bilateral activation of the laryngeal/phonatory area (LPA) of the primary motor cortex as well as activation of the supplementary motor area. The OHC group also recruited additional activity in the bilateral trunk motor area and right dorsal premotor cortex (PMd). A voxel-wise comparison of PD and HC groups showed that activity in right PMd was significantly lower in the PD group compared to OHC (p < 0.001, uncorrected). Right PMd activity was positively correlated with maximum phonation time in the PD group and negatively correlated with perceptual severity ratings of loudness and pitch.DiscussionOur findings suggest that hypoactivation of PMd may be associated with abnormal phonatory control in PD.

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Mapping typical and hypokinetic dysarthric speech production network using a connected speech paradigm in functional MRI

Cited by 7 publications

References 68 publications

A systematic review of studies on connected speech processing: Trends, key findings, and implications

A systematic review of studies on connected speech processing: Trends, key findings, and implications

A neurocomputational view of the effects of Parkinson’s disease on speech production

Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson’s disease and hypophonia

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