Marathon Running Leads to Partial Exhaustion of ROS-Generating Capacity in Leukocytes

Nielsen, Hilde Grindvik; Hagberg, Inger Anne; Lyberg, Torstein

doi:10.1249/01.mss.0000106168.12113.95

Cited by 19 publications

(30 citation statements)

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“…However, the response is compound, and a coincident inhibition of the adaptive immune system may also take place . The net influence is a mixed-up picture of effects on the different subpopulations of cells and their mediators (Nielsen et al 2004;Bøyum et al 1996;Smith et al 1996). Infection rates after prolonged physical stress are thus often reported to be increased (Heath et al 1992), while others find them to be unaffected or even reduced (Pedersen and Hoffman-Goetz 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The cytokines are produced locally by a variety of cells, and released into the circulation in proportion to the magnitude, duration, and mode of the activating stimulus (Pasquale et al 1996;Halson et al 2003;Rowbottom and Green 2000;Nielsen et al 2004). However, the clinical significance of the accompanying deviations from normal resting values has not been definitely established (Nieman 2000).…”

Section: Introductionmentioning

confidence: 99%

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Seven days’ around the clock exhaustive physical exertion combined with energy depletion and sleep deprivation primes circulating leukocytes

et al. 2006

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Both exhaustive physical exertion and starvation have been reported to induce depression of immune function. The aim of the present study was to investigate the inflammatory environment and state of activation and mediator-producing potential of circulating leukocytes during prolonged physical activity with concomitant energy and sleep deprivation. Eight well-trained males were studied during 7 days of semi-continuous physical activity. Sleep was restricted to about 1 h/24 h, energy intake to 1.5- 3.0 MJ/24 h. Blood was drawn at 07.00 A.M.: on days 0, 2, 4, and 7. Plasma levels of inflammation markers were measured. The response of circulating leukocytes to lipopolysaccharide (LPS; 1 microg mL(-1)), and the effect of added hydrocortisone (10 and 100 nmol L(-1)), were measured in the supernatant after 3 h of incubation in an ex vivo whole blood model. Activation of leukocytes steadily increased as measured by plasma matrix metalloproteinase-9, tumour necrosis factor-alpha, interleukin-1beta, and interleukin-6. Inhibitors of systemic inflammation were either unaltered (tissue inhibitor of matrix metalloproteinase-1) or elevated (plasma interleukin-1 receptor antagonist). Cortisol levels increased on days 2 and 4, but thereafter reverted to baseline values. The leukocytes responded to LPS activation with increasing release of inflammatory cytokines throughout the study period. The anti-inflammatory potency of hydrocortisone decreased. Prolonged multifactorial stress thus activated circulating immune cells and primed them for an increased response to a subsequent microbial challenge.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seven days’ around the clock exhaustive physical exertion combined with energy depletion and sleep deprivation primes circulating leukocytes

et al. 2006

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“…The results of the present study add to the majority of previous reports indicating lack of effect on oxidative stress of ingesting antioxidants beyond the levels obtained by the intake of a well-balanced normal diet. The great disparities as to whether ROS production increases or decreases after physical exercise [8,[15][16][17][18] should be considered when comparing different studies of antioxidant supplementation and exercise-induced stress; likewise, the differences in antioxidant dosages used, the biological potency of different forms of the same antioxidant and the different manufacturers' products. The main explanations for the inconsistencies regarding the effect of antioxidant supplementation on oxidative stress seem to be the different assay techniques used to measure in vitro neutrophil ROS production [1].…”

Section: Discussionmentioning

confidence: 99%

“…No significant differences in the training composition were noted between the periods of 4 weeks of antioxidant supplementation and placebo. During the antioxidant supplementation period, the athletes trained on average 8 …”

Section: Subjectsmentioning

confidence: 99%

“…In this study, we used the ROS-sensitive fluorescence probe dihydroethidium (DHE) and dihydrorhodamine 123 (DHR) for instant determination of intracellular ROS levels in leucocytes harbouring their natural habitat (whole blood). Using this technique, we have previously shown that leucocytes, in particular granulocytes, have an enormous capacity for ROS production and that this is influenced by the physical activity of the individual [8].…”

Section: Introductionmentioning

confidence: 99%

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Effect of antioxidant supplementation on leucocyte expression of reactive oxygen species in athletes

Nielsen

Skjønsberg

Lyberg

2008

Scandinavian Journal of Clinical and Laboratory Investigation

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State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions

Lavin

Coen

Baptista

et al. 2022

Comprehensive Physiology

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For centuries, regular exercise has been acknowledged as a potent stimulus to promote, maintain, and restore healthy functioning of nearly every physiological system of the human body. With advancing understanding of the complexity of human physiology, continually evolving methodological possibilities, and an increasingly dire public health situation, the study of exercise as a preventative or therapeutic treatment has never been more interdisciplinary, or more impactful. During the early stages of the NIH Common Fund Molecular Transducers of Physical Activity Consortium (MoTrPAC) Initiative, the field is well-positioned to build substantially upon the existing understanding of the mechanisms underlying benefits associated with exercise. Thus, we present a comprehensive body of the knowledge detailing the current literature basis surrounding the molecular adaptations to exercise in humans to provide a view of the state of the field at this critical juncture, as well as a resource for scientists bringing external expertise to the field of exercise physiology. In reviewing current literature related to molecular and cellular processes underlying exercise-induced benefits and adaptations, we also draw attention to existing knowledge gaps warranting continued research effort.

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Marathon Running Leads to Partial Exhaustion of ROS-Generating Capacity in Leukocytes

Cited by 19 publications

References 19 publications

Seven days’ around the clock exhaustive physical exertion combined with energy depletion and sleep deprivation primes circulating leukocytes

Seven days’ around the clock exhaustive physical exertion combined with energy depletion and sleep deprivation primes circulating leukocytes

Effect of antioxidant supplementation on leucocyte expression of reactive oxygen species in athletes

State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions

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