Marcadores periféricos e a fisiopatologia do transtorno bipolar

Magalhães, Pedro Vieira da Silva; Fries, Gabriel R.; Kapczinski, Flávio

doi:10.1590/s0101-60832012000200004

Cited by 13 publications

(5 citation statements)

References 98 publications

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“…Regarding oxidative stress, brain cells are more vulnerable to its damage as they present fewer antioxidant enzymes and a high level of oxidant metabolism ( Olmez and Ozyurt, 2012 ). Research has showed an imbalance between oxidative damage and antioxidant defenses in BD ( Magalhães et al, 2012 ; Pfaffenseller et al, 2013 ); depressive and manic episodes are associated with elevated oxidative stress activity ( Andreazza et al, 2007 ; Machado-Vieira et al, 2007 ). In a review, Bauer et al (2014) found results suggesting that elevated levels of peripheral inflammatory cytokines and oxidative stress and reduced levels of neurotrophic factors were associated with poorer cognitive performance in patients with BD.…”

Section: Introductionmentioning

confidence: 99%

Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging

Vasconcelos-Moreno

Fries

Gubert

et al. 2017

International Journal of Neuropsychopharmacology

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Background:Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls.Methods:Thirty-six patients with bipolar disorder type I, 39 siblings, and 44 healthy controls were assessed. Serum levels of brain-derived neurotrophic factor, interleukin-6, interleukin-10, tumor necrosis factor-α, C-C motif chemokine 11, C-C motif chemokine 24, and 3-nitrotyrosine were measured, as were the activities of glutathione peroxidase, glutathione reductase, and glutathione S-transferase. Telomere length (T/S ratio) was measured using quantitative polymerase chain reaction.Results:Telomere length was different between the 3 groups (P = .041) with both patients and siblings showing a shorter T/S ratio compared with healthy controls. Patients showed increased levels of interleukin-6 (P = .005) and interleukin-10 (P = .002) compared with controls as well as increased levels of interleukin-6 (p = 0.014) and CCL24 (P = .016) compared with their siblings. C-C motif chemokine 11 levels were increased in siblings compared with controls (P = .015), and a similar tendency was found in patients compared with controls (P = .045). Glutathione peroxidase activity was decreased in patients compared with controls (P = .006) and siblings (P = .025). No differences were found for the other markers.Conclusions:The present results suggest that unaffected siblings may present accelerated aging features. These neurobiological findings may be considered as endophenotypic traits. Further prospective studies are warranted.

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Section: Introductionmentioning

confidence: 99%

Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging

Vasconcelos-Moreno

Fries

Gubert

et al. 2017

International Journal of Neuropsychopharmacology

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“…Isso leva a supressão da resposta de estresse fisiológico baseado no feedback negativo (alostase), ou a uma alteração na quantidade de receptores nessas áreas neurais e, consequentemente, os níveis baixos de cortisol podem causar uma importante mudança no medo e na resposta de luta/fuga fisiológica (Carvalho et al, 2016). Esse mesmo processo está envolvido na gênese de alguns distúrbios psiquiátricos como o transtorno bipolar, especialmente se a criança tiver uma predisposição genética (Magalhães, Fries & Kapczinski, 2012).…”

Section: Resultsunclassified

Fatores socioeconômicos e saúde de crianças em contexto de violência

Aquino¹,

Ataíde²,

Oliveira³

et al. 2021

Aletheia

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Resumo: Esse estudo objetivou analisar a violência infantil no contexto brasileiro, correlacionando-a com fatores socioeconômicos, socioculturais, geracionais e de gênero, investigando o impacto dos mesmos na saúde das crianças. Realizou-se um estudo epidemiológico descritivo, realizado a partir de dados de artigos científicos e documentos oficiais sobre e violência infantil, além do banco de dados do Sistema de Informação de Agravos de Notificação (SINAN) e da plataforma SciELO e Google Acadêmico. Encontrou-se uma maior prevalência de violência física e negligência, maior índice de violência sexual contra o sexo feminino e negligência no sexo masculino. Os principais agressores identificados foram o pai e a mãe. Acerca da etnia, crianças pardas foram as mais agredidas, bem como as de menor escolaridade. As consequências da violência infantil se estendem para além do momento da agressão, ao perturbar funções cognitivas e mesmo influenciar na gênese de transtornos psiquiátricos.

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“…Furthermore, IL-1β levels were also significantly elevated in chronic euthymic BD (Hamdani et al, 2013;Goldsmith et al, 2016). This IL-1 activates the transcription factor NF-κB, which in turn enhances the expression and release of IL-6, IL-8, and interferon-gamma (Magalhães et al, 2012;Kany et al, 2019) Thus, Rowland et al (2018) concluded that while no single biomarker was able to differentiate mood phases or evaluate the stages of the disease, specific combinations including IL-6, BDNF, TNF-α, TNFR1, IL-2, IL-10, and IL-4, were correlated with the disease's stages. These findings demonstrate a significant link between the immune system and BD pathophysiological pathways.…”

Section: Inflammatory Cytokinesmentioning

confidence: 95%

Concepts of Neuroinflammation and Their Relationship With Impaired Mitochondrial Functions in Bipolar Disorder

Cyrino

Lima

Ullmann

et al. 2021

Front. Behav. Neurosci.

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Bipolar disorder (BD) is a chronic psychiatric disease, characterized by frequent behavioral episodes of depression and mania, and neurologically by dysregulated neurotransmission, neuroplasticity, growth factor signaling, and metabolism, as well as oxidative stress, and neuronal apoptosis, contributing to chronic neuroinflammation. These abnormalities result from complex interactions between multiple susceptibility genes and environmental factors such as stress. The neurocellular abnormalities of BD can result in gross morphological changes, such as reduced prefrontal and hippocampal volume, and circuit reorganization resulting in cognitive and emotional deficits. The term “neuroprogression” is used to denote the progressive changes from early to late stages, as BD severity and loss of treatment response correlate with the number of past episodes. In addition to circuit and cellular abnormalities, BD is associated with dysfunctional mitochondria, leading to severe metabolic disruption in high energy-demanding neurons and glia. Indeed, mitochondrial dysfunction involving electron transport chain (ETC) disruption is considered the primary cause of chronic oxidative stress in BD. The ensuing damage to membrane lipids, proteins, and DNA further perpetuates oxidative stress and neuroinflammation, creating a perpetuating pathogenic cycle. A deeper understanding of BD pathophysiology and identification of associated biomarkers of neuroinflammation are needed to facilitate early diagnosis and treatment of this debilitating disorder.

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Marcadores periféricos e a fisiopatologia do transtorno bipolar

Cited by 13 publications

References 98 publications

Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging

Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging

Fatores socioeconômicos e saúde de crianças em contexto de violência

Concepts of Neuroinflammation and Their Relationship With Impaired Mitochondrial Functions in Bipolar Disorder

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