Abstract.In this paper, we study the inverse scattering problem for ZS-AKNS systems on the half-line with general boundary conditions at the origin. For the class of potentials with certain integrability properties, we give a complete description of the corresponding scattering functions S, justify the algorithm reconstructing the potential and the boundary conditions from S, and prove that the scattering map is homeomorphic.Mathematics Subject Classification. Primary 34L25; Secondary 34L40, 81U20, 81U40.