Margin distance and other clinico-pathologic prognostic factors in vulvar carcinoma: A multivariate analysis

Midline Involvement as a Risk Factor for Vulvar Cancer Recurrence

“…Potential risk factors for vulvar rancer recurrences include stage, tumour size, depth of invasion, tumor free margin, lymphovascular space invasion, age and nodal involvement. Althought the importance of these risk factors is inconclusive and varies across the studies (Andreasson et al, 1985;Podratz et al, 1983;Hefler et al, 1999;Chan et al, 2007). …”

Invasive vulvar carcinoma and the question of the surgical margin

“…Among these variables, the width of the margin is the only one that can be "tailored" at the time of surgery. The proper width of the surgical margin, however, remains a matter of debate among gynecologic surgeons [2][3][4][5][6][7].…”

“…It is therefore generally recommended that surgeons allow a margin of 1 cm around the resected lesion [5,7]. However, de Hullu et al [8] found that a surgical margin of 1 cm resulted in a microscopic margin less than 8 mm in 50% of cases, and suggested that the rates of local recurrence were high because of 1-cm surgical margins.…”

European Nationality Influence in the Management of Squamous Cell Vulvar Cancer

“…Heaps et al [11] concluded that a tumor-free surgical margin of 1 cm allows a high rate of local control. In another study, Chan et al [12] analyzed 90 cancers of the vulva and reported that none of the 30 patients with a free histological tumor margin of 8 mm or more had local recurrence and 12 (23%) of the 53 women with a histological margin of less than 8 mm had a local recurrence. De Hullu et al [13] showed that a surgical-free margin of 1 cm corresponded histologically with less pathological margin to 8 mm in 50% of patients, which correlated to a higher rate of local recurrence.…”